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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zb1GK4Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zb1GK4Mitogen-activated protein kinase 14/1.000
2gfsPQBMitogen-activated protein kinase 14/0.601
3ds6A17Mitogen-activated protein kinase 14/0.590
3iphG11Mitogen-activated protein kinase 14/0.554
3itzP66Mitogen-activated protein kinase 14/0.543
3s4qNK0Mitogen-activated protein kinase 14/0.538
1w7h3IPMitogen-activated protein kinase 14/0.529
2zb0GK3Mitogen-activated protein kinase 14/0.519
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.505
3fskRO6Mitogen-activated protein kinase 14/0.499
3uvqFS8Mitogen-activated protein kinase 14/0.498
3fklFKLMitogen-activated protein kinase 14/0.497
3gc9B45Mitogen-activated protein kinase 112.7.11.240.497
3l8xN4DMitogen-activated protein kinase 14/0.494
3lfeZ84Mitogen-activated protein kinase 14/0.490
1wbwLI4Mitogen-activated protein kinase 14/0.487
3fl4FL4Mitogen-activated protein kinase 14/0.487
3fkoFKOMitogen-activated protein kinase 14/0.486
3bx5304Mitogen-activated protein kinase 14/0.485
3pg3DG7Mitogen-activated protein kinase 14/0.485
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.483
3mpt1GKMitogen-activated protein kinase 14/0.482
3fmmXI2Mitogen-activated protein kinase 14/0.479
3d7zGK5Mitogen-activated protein kinase 14/0.478
1zzlTZYMitogen-activated protein kinase 14/0.477
3dt1P40Mitogen-activated protein kinase 14/0.477
3rinI2OMitogen-activated protein kinase 14/0.477
3zsh469Mitogen-activated protein kinase 14/0.476
4kip1R9Mitogen-activated protein kinase 14/0.476
4o2z046Mitogen-activated protein kinase/0.476
2balPQAMitogen-activated protein kinase 14/0.474
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.474
3hub469Mitogen-activated protein kinase 14/0.474
3hng8STVascular endothelial growth factor receptor 12.7.10.10.473
4aacAAVMitogen-activated protein kinase 14/0.473
3e92G6AMitogen-activated protein kinase 14/0.472
2rg6287Mitogen-activated protein kinase 14/0.471
3fknFKNMitogen-activated protein kinase 14/0.471
3u8w09JMitogen-activated protein kinase 14/0.471
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.470
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.470
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
4eyjN61Mitogen-activated protein kinase 132.7.11.240.470
3hv5R24Mitogen-activated protein kinase 14/0.469
2og81N8Tyrosine-protein kinase Lck2.7.10.20.465
3ol5SAWCamphor 5-monooxygenase1.14.15.10.465
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.465
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.465
5k2cZMAAdenosine receptor A2a/0.462
3ce31FNHepatocyte growth factor receptor2.7.10.10.461
3gfeP37Mitogen-activated protein kinase 14/0.459
3uibSB2Putative mitogen-activated protein kinase/0.459
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.459
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.457
3ctj320Hepatocyte growth factor receptor2.7.10.10.456
3nww3NWMitogen-activated protein kinase 14/0.456
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
4eh60ONMitogen-activated protein kinase 14/0.456
3iw8HIZMitogen-activated protein kinase 14/0.455
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.455
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.455
3eta351Insulin receptor2.7.10.10.454
3gcq1BUMitogen-activated protein kinase 14/0.454
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.453
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.453
3hp552PMitogen-activated protein kinase 14/0.451
1zyjBI5Mitogen-activated protein kinase 14/0.449
4aa5NQBMitogen-activated protein kinase 14/0.449
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
3hv3R49Mitogen-activated protein kinase 14/0.448
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.447
5iua6DXAdenosine receptor A2a/0.446
3c5uP41Mitogen-activated protein kinase 14/0.445
3ocgOCGMitogen-activated protein kinase 14/0.445
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.444
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.443
3cwkREACellular retinoic acid-binding protein 2/0.443
3fln3FNMitogen-activated protein kinase 14/0.442
4aa4QC0Mitogen-activated protein kinase 14/0.442
3mpaSB2Mitogen-activated protein kinase 14/0.441
5k2bZMAAdenosine receptor A2a/0.441
3p6mDSOCamphor 5-monooxygenase1.14.15.10.440
4kin1M8Mitogen-activated protein kinase 14/0.440