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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zb0GK3Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zb0GK3Mitogen-activated protein kinase 14/1.000
2zazGK1Mitogen-activated protein kinase 14/0.600
3l8xN4DMitogen-activated protein kinase 14/0.583
2gfsPQBMitogen-activated protein kinase 14/0.575
3gfeP37Mitogen-activated protein kinase 14/0.569
3iphG11Mitogen-activated protein kinase 14/0.565
1ouy094Mitogen-activated protein kinase 14/0.561
3uvqFS8Mitogen-activated protein kinase 14/0.558
2zb1GK4Mitogen-activated protein kinase 14/0.555
3s4qNK0Mitogen-activated protein kinase 14/0.550
4aa5NQBMitogen-activated protein kinase 14/0.544
1w7h3IPMitogen-activated protein kinase 14/0.542
3mpaSB2Mitogen-activated protein kinase 14/0.535
3fskRO6Mitogen-activated protein kinase 14/0.534
3ha85JZMitogen-activated protein kinase 14/0.528
3hp552PMitogen-activated protein kinase 14/0.527
4nka2K7Fibroblast growth factor receptor 1/0.527
3ds6A17Mitogen-activated protein kinase 14/0.525
3hllI45Mitogen-activated protein kinase 14/0.525
2rg6287Mitogen-activated protein kinase 14/0.521
1zyjBI5Mitogen-activated protein kinase 14/0.520
1di9MSQMitogen-activated protein kinase 14/0.518
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.517
1w84L12Mitogen-activated protein kinase 14/0.516
3u8w09JMitogen-activated protein kinase 14/0.514
3itzP66Mitogen-activated protein kinase 14/0.513
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.512
3fmh533Mitogen-activated protein kinase 14/0.511
3roc29AMitogen-activated protein kinase 14/0.511
3fmn530Mitogen-activated protein kinase 14/0.509
1bl6SB6Mitogen-activated protein kinase 14/0.506
3mpt1GKMitogen-activated protein kinase 14/0.506
3fklFKLMitogen-activated protein kinase 14/0.504
3flwFLWMitogen-activated protein kinase 14/0.503
3flzFLZMitogen-activated protein kinase 14/0.502
3flsFLSMitogen-activated protein kinase 14/0.501
3uibSB2Putative mitogen-activated protein kinase/0.501
4eh60ONMitogen-activated protein kinase 14/0.501
1ouk084Mitogen-activated protein kinase 14/0.500
3dt1P40Mitogen-activated protein kinase 14/0.500
3fl4FL4Mitogen-activated protein kinase 14/0.499
3gc7B45Mitogen-activated protein kinase 14/0.499
3uvp048Mitogen-activated protein kinase 14/0.499
3bv2P38Mitogen-activated protein kinase 14/0.497
4aacAAVMitogen-activated protein kinase 14/0.497
3fsfFSSMitogen-activated protein kinase 14/0.494
4aa4QC0Mitogen-activated protein kinase 14/0.494
2balPQAMitogen-activated protein kinase 14/0.493
2qd9LGFMitogen-activated protein kinase 14/0.491
3lfa1N1Mitogen-activated protein kinase 14/0.491
4eh50OMMitogen-activated protein kinase 14/0.490
3fi4FI4Mitogen-activated protein kinase 14/0.487
3lfeZ84Mitogen-activated protein kinase 14/0.487
2rg5279Mitogen-activated protein kinase 14/0.486
3fmkFMKMitogen-activated protein kinase 14/0.486
1zzlTZYMitogen-activated protein kinase 14/0.485
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.484
3gc9B45Mitogen-activated protein kinase 112.7.11.240.483
3fln3FNMitogen-activated protein kinase 14/0.482
1ove358Mitogen-activated protein kinase 14/0.481
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.481
4kiq1RAMitogen-activated protein kinase 14/0.481
1ywrLI9Mitogen-activated protein kinase 14/0.480
3fc152PMitogen-activated protein kinase 14/0.480
4kip1R9Mitogen-activated protein kinase 14/0.479
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.478
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.477
3bx5304Mitogen-activated protein kinase 14/0.477
3flyFLYMitogen-activated protein kinase 14/0.477
3mvl38PMitogen-activated protein kinase 14/0.477
3hub469Mitogen-activated protein kinase 14/0.476
1dssNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.475
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.475
3nww3NWMitogen-activated protein kinase 14/0.473
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.472
3fkoFKOMitogen-activated protein kinase 14/0.472
3fmlFMLMitogen-activated protein kinase 14/0.472
3vs3VSETyrosine-protein kinase HCK2.7.10.20.472
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.472
2izrBRKCasein kinase I isoform gamma-32.7.11.10.471
3hl7I47Mitogen-activated protein kinase 14/0.471
1gx1CDP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.470
3zsh469Mitogen-activated protein kinase 14/0.470
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.467
4kin1M8Mitogen-activated protein kinase 14/0.466
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3ocgOCGMitogen-activated protein kinase 14/0.465
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.465
3fknFKNMitogen-activated protein kinase 14/0.464
4dlj6RGMitogen-activated protein kinase 14/0.464
4eym0RXMitogen-activated protein kinase 132.7.11.240.463
3l8sBFFMitogen-activated protein kinase 14/0.461
1k6pXN3Gag-Pol polyprotein3.4.23.160.460
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2q3kMUWGag-Pol polyprotein/0.459
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.458
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.458
3ac1KZITyrosine-protein kinase Lck2.7.10.20.457
2gtnLIEMitogen-activated protein kinase 14/0.456
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.456
2yixYIXMitogen-activated protein kinase 14/0.456
1t3r017Gag-Pol polyprotein3.4.23.160.455
3bv3P39Mitogen-activated protein kinase 14/0.455
3mvm39PMitogen-activated protein kinase 14/0.455
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.455
3hv3R49Mitogen-activated protein kinase 14/0.454
3ac2KSETyrosine-protein kinase Lck2.7.10.20.453
1k6vXN2Gag-Pol polyprotein3.4.23.160.452
1ohr1UNV-1 PROTEASE protein/0.452
2itqITQEpidermal growth factor receptor2.7.10.10.452
2xszATPRuvB-like 23.6.4.120.452
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.452
3fmmXI2Mitogen-activated protein kinase 14/0.452
3w2o03PEpidermal growth factor receptor2.7.10.10.452
2fgiPD1Fibroblast growth factor receptor 1/0.451
2xyeCXGGag-Pol polyprotein/0.451
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3e92G6AMitogen-activated protein kinase 14/0.451
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.451
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
1m7qDQOMitogen-activated protein kinase 14/0.450
1wbwLI4Mitogen-activated protein kinase 14/0.450
2ewaSB2Mitogen-activated protein kinase 14/0.450
3rinI2OMitogen-activated protein kinase 14/0.450
3w2sW2REpidermal growth factor receptor2.7.10.10.450
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
5cvfATPCasein kinase II subunit alpha2.7.11.10.450
2ghmLICMitogen-activated protein kinase 14/0.449
2itwITQEpidermal growth factor receptor2.7.10.10.449
2y6o1N1Ephrin type-A receptor 42.7.10.10.449
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.449
5k2cZMAAdenosine receptor A2a/0.449
1xkkFMMEpidermal growth factor receptor2.7.10.10.448
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.448
3pg3DG7Mitogen-activated protein kinase 14/0.448
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.448
5k2bZMAAdenosine receptor A2a/0.448
1b4vFADCholesterol oxidase1.1.3.60.447
1bl7SB4Mitogen-activated protein kinase 14/0.447
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.447
4djqM86Pol polyprotein/0.447
4jr3KJREpidermal growth factor receptor2.7.10.10.447
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
2ituITQEpidermal growth factor receptor2.7.10.10.446
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.446
2yaaATPDeath-associated protein kinase 2/0.446
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
3cmcNADGlyceraldehyde-3-phosphate dehydrogenase/0.445
4i22IREEpidermal growth factor receptor2.7.10.10.445
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.445
2nuaCOASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.444
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.444
3fmjFMJMitogen-activated protein kinase 14/0.444
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.443
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2gejGDDPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.443
4l9i8PRRhodopsin kinase/0.443
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2hk51BMTyrosine-protein kinase HCK2.7.10.20.442
3hucG97Mitogen-activated protein kinase 14/0.442
3orpAGSSerine/threonine protein kinase/0.442
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.442
2gekGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.441
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.441
4dqb017Gag-Pol polyprotein/0.441
4gk2L66Ephrin type-A receptor 32.7.10.10.441
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.441
2jn3JN3Fatty acid-binding protein, liver/0.440
2qd7065Gag-Pol polyprotein3.4.23.160.440
2qi6MZ8Gag-Pol polyprotein/0.440
3cnjFADCholesterol oxidase1.1.3.60.440
3gi5K62Gag-Pol polyprotein/0.440
4nk92K5Fibroblast growth factor receptor 1/0.440