sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.749 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.720 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.715 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.690 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.689 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.688 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.679 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.675 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.671 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.663 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.663 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.659 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.642 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.642 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.640 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.619 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.617 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.601 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.597 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.590 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.590 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.586 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.581 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.579 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.572 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.558 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.525 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.523 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.522 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.522 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.518 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.518 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.508 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.506 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.505 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.502 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.498 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.495 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.494 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.493 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.489 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.488 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.486 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.485 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.483 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.482 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.482 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.479 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.476 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.475 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.474 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.474 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.466 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.466 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.466 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.465 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.464 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.463 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.462 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.461 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.460 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.460 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.460 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 2y3s | TIR | TamL | / | 0.458 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.458 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.458 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.457 | |
| 3eej | 53R | Uncharacterized protein | / | 0.456 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.456 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.456 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.455 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.454 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.454 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.453 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.452 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.452 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.452 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.450 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.450 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.450 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.448 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.448 | |
| 3gob | HXX | DdmC | / | 0.448 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.448 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.447 | |
| 4zca | ADP | Kinesin-like protein KIF11 | / | 0.447 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4ihl | 1F5 | 14-3-3 protein zeta/delta | / | 0.446 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.445 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 5dg3 | U21 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.445 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.443 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.443 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.443 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.442 | |
| 5c7o | NAD | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | 1.2.1.12 | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.441 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.441 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.441 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 |