sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 1.000 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.563 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.528 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.521 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.516 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.514 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.511 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.509 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.499 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.499 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.497 | |
| 4qec | NAP | ElxO | / | 0.497 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.497 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.496 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.495 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.494 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.493 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.489 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.486 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.486 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.486 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.486 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.480 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.479 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.478 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.478 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.477 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.476 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.475 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.475 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.474 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.474 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.472 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.470 | |
| 3sju | NDP | Keto reductase | / | 0.469 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.466 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.465 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.464 | |
| 1sny | NAP | LD36273p | / | 0.463 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.463 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.462 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.462 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.462 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.462 | |
| 3uce | NDP | Dehydrogenase | / | 0.460 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.459 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.459 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.456 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.454 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.453 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.453 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.453 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.452 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.451 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.451 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.450 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.450 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.449 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.449 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.449 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.449 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.447 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.446 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.445 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.445 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.442 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.440 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.440 |