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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.695
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.688
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.675
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.670
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.664
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.652
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.634
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.620
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.619
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.618
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.606
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.595
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.594
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.592
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.584
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.583
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.575
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.569
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.569
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.502
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.470
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.444