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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2yisYISMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2yisYISMitogen-activated protein kinase 14/1.000
1kv2B96Mitogen-activated protein kinase 14/0.634
3p7bP7BMitogen-activated protein kinase 14/0.631
3p7aP7AMitogen-activated protein kinase 14/0.607
3nnuEDBMitogen-activated protein kinase 14/0.580
3uvr06FMitogen-activated protein kinase 14/0.570
3nnwEDDMitogen-activated protein kinase 14/0.564
3hv6R39Mitogen-activated protein kinase 14/0.563
3gcuR48Mitogen-activated protein kinase 14/0.559
3p7cP7CMitogen-activated protein kinase 14/0.558
3lfbZ87Mitogen-activated protein kinase 14/0.553
1kv1BMUMitogen-activated protein kinase 14/0.541
1w82L10Mitogen-activated protein kinase 14/0.541
1wbsLI2Mitogen-activated protein kinase 14/0.540
3hv71AUMitogen-activated protein kinase 14/0.539
1wbtWBTMitogen-activated protein kinase 14/0.538
3p5kP5KMitogen-activated protein kinase 14/0.535
2puuG2GMitogen-activated protein kinase 14/0.533
3hv4L51Mitogen-activated protein kinase 14/0.530
1wbvLI3Mitogen-activated protein kinase 14/0.527
3nnxEDDMitogen-activated protein kinase 14/0.523
3gcvSS6Mitogen-activated protein kinase 14/0.521
3p79P79Mitogen-activated protein kinase 14/0.521
3lffZ83Mitogen-activated protein kinase 14/0.511
3npcB96Mitogen-activated protein kinase 92.7.11.240.509
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.500
3k3jF4CMitogen-activated protein kinase 14/0.492
3p78P78Mitogen-activated protein kinase 14/0.491
3nu3478Gag-Pol polyprotein3.4.23.160.488
2yiwYIWMitogen-activated protein kinase 14/0.483
3o8uBMUMitogen-activated protein kinase 14/0.483
4eh90OQMitogen-activated protein kinase 14/0.483
2xclANPPhosphoribosylamine--glycine ligase/0.478
3gi3B10Mitogen-activated protein kinase 14/0.476
3d83GK6Mitogen-activated protein kinase 14/0.473
2q641UNGag-Pol polyprotein3.4.23.160.467
1ec3MS3Gag-Pol polyprotein3.4.23.160.466
3dfcANPDeath-associated protein kinase 12.7.11.10.464
2bpy3INGag-Pol polyprotein3.4.23.160.462
3h0sB38Acetyl-CoA carboxylase/0.462
3kddJZQGag-Pol polyprotein3.4.23.160.462
2v51LABActin, alpha skeletal muscle/0.461
3t54ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.461
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.459
3ogqAB1Pol polyprotein/0.459
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.458
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.458
1ia9ANPTransient receptor potential cation channel subfamily M member 72.7.11.10.457
1wbk568Pol protein/0.457
2bpz3INGag-Pol polyprotein3.4.23.160.457
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3i7eDJRGag-Pol polyprotein/0.457
1k6pXN3Gag-Pol polyprotein3.4.23.160.456
2v52LABActin, alpha skeletal muscle/0.456
3ix9MTXDihydrofolate reductase1.5.1.30.456
2bpw1INGag-Pol polyprotein3.4.23.160.455
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.455
4b1vLABActin, alpha skeletal muscle/0.455
1bai0Q4Gag-Pro polyprotein/0.454
1nvfADPPentafunctional AROM polypeptide/0.454
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.453
3cs9NILTyrosine-protein kinase ABL12.7.10.20.453
3nwyGTPUridylate kinase/0.453
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.453
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.451
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4nka2K7Fibroblast growth factor receptor 1/0.451
1jld0PPGag-Pol polyprotein/0.450
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.450
2yxlSFG450aa long hypothetical fmu protein/0.450
3e9319BMitogen-activated protein kinase 14/0.450
3el9DR7Gag-Pol polyprotein3.4.23.160.450
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.450
1bvgDMPGag-Pol polyprotein3.4.23.160.449
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2pk5075Protease/0.449
2q3kMUWGag-Pol polyprotein/0.449
2qak1UNGag-Pol polyprotein3.4.23.160.449
2y9qANPMitogen-activated protein kinase 12.7.11.240.449
3nieANPMitogen-activated protein kinase/0.449
3qaaG04Gag-Pol polyprotein3.4.23.160.449
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.449
1hpxKNIGag-Pol polyprotein/0.448
3mx5UTPNucleoprotein/0.448
4f640S8Fibroblast growth factor receptor 1/0.448
4jbpYPHAurora kinase A2.7.11.10.448
1reoFADL-amino-acid oxidase1.4.3.20.447
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3js2VM1Fibroblast growth factor receptor 1/0.447
1merDMQGag-Pol polyprotein3.4.23.160.446
2bpv1INGag-Pol polyprotein3.4.23.160.446
2uy0HV1Gag-Pol polyprotein3.4.23.160.446
5j4eFMNSensory box protein/0.446
2xir00JVascular endothelial growth factor receptor 22.7.10.10.445
1bwb146Gag-Pol polyprotein3.4.23.160.444
1hxwRITGag-Pol polyprotein/0.444
1ivq0PXGag-Pol polyprotein/0.444
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1nvaADPPentafunctional AROM polypeptide/0.444
1wbnL09Mitogen-activated protein kinase 14/0.444
2avvMK1Gag-Pol polyprotein3.4.23.160.444
4l8mF46Mitogen-activated protein kinase 14/0.444
5j3wFMNSensory box protein/0.444
1hsgMK1Gag-Pol polyprotein/0.443
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.443
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.443
2cciATPCyclin-dependent kinase 22.7.11.220.443
2cmvNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
2vrx447Aurora kinase B-A2.7.11.10.443
3hzc2NCProtease/0.443
3nwq2NCGag-Pol polyprotein3.4.23.160.443
1b6kPI5Gag-Pol polyprotein3.4.23.160.442
1idb0DOGag-Pol polyprotein/0.442
2qhyMZ1Gag-Pol polyprotein/0.442
3s56ROCProtease/0.442
3tl9ROCGag-Pol polyprotein3.4.23.160.442
3ugc046Tyrosine-protein kinase JAK2/0.442
4hdfG52Gag-Pol polyprotein3.4.23.160.442
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4j95ACPFibroblast growth factor receptor 2/0.442
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
1b6lPI4Gag-Pol polyprotein3.4.23.160.441
1ohr1UNV-1 PROTEASE protein/0.441
1w2xRCPAcetyl-CoA carboxylase/0.441
2f8g017Gag-Pol polyprotein3.4.23.160.441
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.441
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.441
4anmWULCasein kinase II subunit alpha2.7.11.10.441
4f7n0SVCyclin-dependent kinase 82.7.11.220.441
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.441
1a8g2Z4Gag-Pol polyprotein3.4.23.160.440
1hihC20Gag-Pol polyprotein/0.440
1hpoUNIGag-Pol polyprotein3.4.23.160.440
2cen4AHProtease/0.440
2gd2CAAProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.440
3q92XNBKetohexokinase/0.440
3ufnROCGag-Pol polyprotein/0.440
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.440
5br4NADLactaldehyde reductase1.1.1.770.440
4z34ON7Lysophosphatidic acid receptor 1/0.440