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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.56

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.561.000
4fn4NADShort chain dehydrogenase/0.509
1g6kNADGlucose 1-dehydrogenase1.1.1.470.503
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.494
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.490
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.487
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.482
4hwkNAPSepiapterin reductase1.1.1.1530.482
2hizLIJBeta-secretase 13.4.23.460.480
3vdqNAD3-hydroxybutyrate dehydrogenase/0.479
3wdsNADNADH-dependent quinuclidinone reductase/0.479
4dbzNDPPutative ketoacyl reductase1.3.10.479
2gesCOKPantothenate kinase2.7.1.330.478
4yagNAIC alpha-dehydrogenase/0.478
4yaiNAIC alpha-dehydrogenase/0.478
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.477
1oaaNAPSepiapterin reductase1.1.1.1530.476
3p19NDPPutative blue fluorescent protein/0.476
3orfNADDihydropteridine reductase1.5.1.340.475
4gh5NADShort-chain dehydrogenase/reductase SDR/0.475
4j7xNAPSepiapterin reductase1.1.1.1530.475
1dhrNADDihydropteridine reductase1.5.1.340.473
3nsh957Beta-secretase 13.4.23.460.472
4i0i957Beta-secretase 13.4.23.460.472
3ai3NDPNADPH-sorbose reductase/0.471
4dc0NDPPutative ketoacyl reductase1.3.10.471
5idwNAPShort-chain dehydrogenase/reductase SDR/0.470
1ipeNDPTropinone reductase 21.1.1.2360.469
3autNAIGlucose 1-dehydrogenase 41.1.1.470.469
3c1y2BADNA integrity scanning protein DisA/0.469
4frkDWDBeta-secretase 13.4.23.460.469
3duyAFJBeta-secretase 13.4.23.460.468
3s55NADPutative short-chain dehydrogenase/reductase/0.468
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.468
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.467
4j7uNAPSepiapterin reductase1.1.1.1530.467
1fxsNAPGDP-L-fucose synthase/0.466
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.465
1nahNADUDP-glucose 4-epimerase5.1.3.20.462
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.462
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.462
1hdrNADDihydropteridine reductase1.5.1.340.461
1me6IVSPlasmepsin-23.4.23.390.461
2hm1LIQBeta-secretase 13.4.23.460.461
1gcoNADGlucose 1-dehydrogenase1.1.1.470.460
1psa0ZLPepsin A3.4.23.10.460
2hldANPATP synthase subunit alpha, mitochondrial/0.460
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.460
4acuQN7Beta-secretase 13.4.23.460.460
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.460
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.459
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
2viyVG3Beta-secretase 13.4.23.460.459
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.459
4q71FADBifunctional protein PutA/0.459
3toxNAPPutative oxidoreductase/0.458
1dirNADDihydropteridine reductase1.5.1.340.457
1ma0NADAlcohol dehydrogenase class-31.1.1.10.457
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.457
2ifaFMNUncharacterized protein/0.457
2wdzNADGalactitol dehydrogenase/0.457
4kwhNAPReductase homolog/0.457
5jlaNADPutative short-chain dehydrogenase/reductase/0.457
1rwbNADGlucose 1-dehydrogenase1.1.1.470.456
1vsoAT1Glutamate receptor ionotropic, kainate 1/0.456
3lpjZ75Beta-secretase 13.4.23.460.456
2p83MR0Beta-secretase 13.4.23.460.455
3dv1AR9Beta-secretase 13.4.23.460.455
4esoNAPPutative oxidoreductase/0.455
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.455
4u7wNDPMxaA/0.455
2gevCOKPantothenate kinase2.7.1.330.454
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.454
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.454
4b722FBBeta-secretase 13.4.23.460.454
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.453
3lpkZ76Beta-secretase 13.4.23.460.453
3lqfNADGalactitol dehydrogenase/0.453
3w8eNAD3-hydroxybutyrate dehydrogenase/0.453
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.452
3pndFADFAD:protein FMN transferase/0.452
3veu0GOBeta-secretase 13.4.23.460.452
1cdoNADAlcohol dehydrogenase 11.1.1.10.451
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.451
4acxS8ZBeta-secretase 13.4.23.460.451
1kvrNADUDP-glucose 4-epimerase5.1.3.20.450
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.450
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.450
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1bsvNDPGDP-L-fucose synthase/0.449
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
2c20NADUDP-glucose 4-epimerase/0.449
3ctyFADProbable thioredoxin reductase/0.449
3k5gBJCBeta-secretase 13.4.23.460.449
3oeeANPATP synthase subunit alpha, mitochondrial/0.449
3oeeANPATP synthase subunit beta, mitochondrial3.6.3.140.449
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1iy8NADLevodione reductase/0.448
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.448
3gy0NAPNAD(P)-dependent oxidoreductase/0.448
4dpf0LGBeta-secretase 13.4.23.460.448
1bk0ACVIsopenicillin N synthase1.21.3.10.447
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.447
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.447
2c29NAPDihydroflavonol 4-reductase/0.447
3ggoNAIPrephenate dehydrogenase/0.447
4cpdNADAlcohol dehydrogenase/0.447
4dpi0N1Beta-secretase 13.4.23.460.447
4gid0GHBeta-secretase 13.4.23.460.447
4i0h1BLBeta-secretase 13.4.23.460.447
1knrFADL-aspartate oxidase1.4.3.160.446
3cluFADElectron transfer flavoprotein subunit alpha/0.446
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.446
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1pr9NAPL-xylulose reductase1.1.1.100.445
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.445
2ignFADPyranose 2-oxidase/0.445
3a4vNADNDP-sugar epimerase/0.445
3cid318Beta-secretase 13.4.23.460.445
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.445
3zksWZVBeta-secretase 23.4.23.450.445
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.445
1rneC60Renin3.4.23.150.444
3ohh3HHBeta-secretase 13.4.23.460.444
5dp2NAPCurF/0.444
1lf3EH5Plasmepsin-23.4.23.390.443
1naiNADUDP-glucose 4-epimerase5.1.3.20.443
2getCOKPantothenate kinase2.7.1.330.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4ewo996Beta-secretase 13.4.23.460.443
4h1e10JBeta-secretase 13.4.23.460.443
1xs7MMIBeta-secretase 13.4.23.460.442
2vbdV10Isopenicillin N synthase1.21.3.10.442
3hl0NADMaleylacetate reductase/0.442
3sx2NADUncharacterized protein/0.442
3vyeVYERenin3.4.23.150.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
5hwsNAP2-dehydropantoate 2-reductase/0.442
1ae1NAPTropinone reductase 1/0.441
1bwsNDPGDP-L-fucose synthase/0.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2ebaFADPutative glutaryl-CoA dehydrogenase/0.441
2iviACWIsopenicillin N synthase1.21.3.10.441
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.441
3cic316Beta-secretase 13.4.23.460.441
3mjeNDPAmphB/0.441
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.440
1x7gNAPPutative ketoacyl reductase1.3.10.440
1x7hNDPPutative ketoacyl reductase1.3.10.440
2gqtFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.440
2iqgF2IBeta-secretase 13.4.23.460.440
3o26NDPSalutaridine reductase/0.440
3sjuNDPKeto reductase/0.440
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
4dju0KKBeta-secretase 13.4.23.460.440
4fse0VABeta-secretase 13.4.23.460.440