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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2y30SM8Putative repressor SimReg2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2y30SM8Putative repressor SimReg2/1.000
3vtcTK3Vitamin D3 receptor/0.461
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
4j6dTESCytochrome P450 monooxygenase/0.456
4eevL1XHepatocyte growth factor receptor2.7.10.10.453
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.453
1pkfEPDEpothilone C/D epoxidase1.140.450
3p9tTCLRepressor/0.450
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
3t2kFADSulfide-quinone reductase/0.448
2jn3JN3Fatty acid-binding protein, liver/0.447
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2ca0PXICytochrome P450 monooxygenase PikC/0.444
3cv9VDXVitamin D3 dihydroxylase/0.443
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.442
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.442
2c6hPXICytochrome P450 monooxygenase PikC/0.441
4b7sQLECytochrome P450 monooxygenase PikC/0.441
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.440