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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xpuTDCTetracycline repressor protein class D

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xpuTDCTetracycline repressor protein class D/1.000
5fklTDCTetracycline repressor protein class D/0.657
2vkeTACTetracycline repressor protein class D/0.645
2xpwOTCTetracycline repressor protein class D/0.605
2trtTACTetracycline repressor protein class D/0.598
2fj1CTCTetracycline repressor protein class D/0.585
4auxXTCTetracycline repressor protein class D/0.584
2xpvMIYTetracycline repressor protein class D/0.568
5fkmTDCTetracycline repressor protein class D/0.566
2xb5I7TTetracycline repressor protein class D/0.553
2x9dITCTetracycline repressor protein class D/0.552
2o7oDXTTetracycline repressor protein class D/0.551
1orkATCTetracycline repressor protein class D/0.541
2tctCTCTetracycline repressor protein class D/0.531
4b1rITCTetracycline repressor protein class D/0.523
4d7mTDCTetracycline repressor protein class D/0.522
4v2gITCTetracycline repressor protein class D/0.517
5fkoTDCTetracycline repressor protein class D/0.517
4abzT1CTetracycline repressor protein class D/0.507
2xrlDXTTetracycline repressor protein class D/0.501
4b3aTACTetracycline repressor protein class D/0.497
1w6hTITPlasmepsin-23.4.23.390.470
2vkvTDCTetracycline repressor protein class D/0.457
5fknTDCTetracycline repressor protein class D/0.452
2vprTDCTetracycline repressor protein class H/0.449