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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.11.000
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.549
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.547
2xnoED8Serine/threonine-protein kinase Nek22.7.11.10.546
2w5bAGSSerine/threonine-protein kinase Nek22.7.11.10.535
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.534
2w5aADPSerine/threonine-protein kinase Nek22.7.11.10.528
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.518
2jav5Z5Serine/threonine-protein kinase Nek22.7.11.10.513
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.513
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.511
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.506
2in6839Wee1-like protein kinase2.7.10.20.500
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.493
2z2w770Wee1-like protein kinase2.7.10.20.493
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.491
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.488
3bi6396Wee1-like protein kinase2.7.10.20.487
2yac937Serine/threonine-protein kinase PLK12.7.11.210.486
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.480
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.479
3biz61EWee1-like protein kinase2.7.10.20.475
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.475
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.473
1x8b824Wee1-like protein kinase2.7.10.20.471
2io6330Wee1-like protein kinase2.7.10.20.471
3cr0809Wee1-like protein kinase2.7.10.20.470
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.468
1wuuANPGalactokinase2.7.1.60.466
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.465
4g1nNZTPyruvate kinase PKM2.7.1.400.465
2owb626Serine/threonine-protein kinase PLK12.7.11.210.462
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.462
3qiyQI1Botulinum neurotoxin type A3.4.24.690.460
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.457
3h4vDVPPteridine reductase 11.5.1.330.457
4eevL1XHepatocyte growth factor receptor2.7.10.10.456
2ejzSAHDiphthine synthase/0.455
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4fnyI3KALK tyrosine kinase receptor2.7.10.10.455
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.454
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.454
1fr8GDUBeta-1,4-galactosyltransferase 1/0.453
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.453
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.453
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.452
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.450
3qm4PN0Cytochrome P450 2D6/0.450
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.449
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.449
4j6bPLOCytochrome P450 monooxygenase/0.449
4jbtASDCytochrome P450 monooxygenase/0.449
2rgjFADFlavin-containing monooxygenase/0.446
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.445
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.445
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
5k2cZMAAdenosine receptor A2a/0.444
1qiqACCIsopenicillin N synthase1.21.3.10.443
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.442
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.442
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.441
3gcq1BUMitogen-activated protein kinase 14/0.440
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.440
4r20AERCytochrome P450 family 17 polypeptide 2/0.440