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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.11.000
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.656
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.645
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.643
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.627
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.608
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.606
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.563
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.555
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.546
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.490
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.475
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.468
1bygSTUTyrosine-protein kinase CSK/0.465
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.463
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.458
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.457
4jbpYPHAurora kinase A2.7.11.10.454
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.451
4i22IREEpidermal growth factor receptor2.7.10.10.449
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.448
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.446
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.444
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.442
4jboWPHAurora kinase A2.7.11.10.442
4id71G0Activated CDC42 kinase 1/0.440