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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xk2ADPHeat shock protein HSP 90-alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2xk2ADPHeat shock protein HSP 90-alpha/1.000
3t10ACPHeat shock protein HSP 90-alpha/0.669
3t2sAGSHeat shock protein HSP 90-alpha/0.668
1byqADPHeat shock protein HSP 90-alpha/0.646
3t1kANPHeat shock protein HSP 90-alpha/0.634
3vhaVHAHeat shock protein HSP 90-alpha/0.634
3r4pFU7Heat shock protein HSP 90-alpha/0.632
4gqtADPHeat shock protein 90/0.632
4ipeANPTNF receptor-associated protein 1/0.625
4egiB2JHeat shock protein HSP 90-alpha/0.623
3hhu819Heat shock protein HSP 90-alpha/0.622
1yszNECEndoplasmin/0.620
4bqjXKLHeat shock protein HSP 90-alpha/0.620
4ce17FKATP-dependent molecular chaperone HSP82/0.620
2byh2D7Heat shock protein HSP 90-alpha/0.617
2yefANPHeat shock protein HSP 90-alpha/0.617
2qg0A94Heat shock protein HSP 90-alpha/0.616
4xcjADPHeat shock cognate 90 kDa protein/0.615
1am1ADPATP-dependent molecular chaperone HSP82/0.614
2yegXQGHeat shock protein HSP 90-alpha/0.614
2iwuNP5ATP-dependent molecular chaperone HSP82/0.610
2xd6XD6ATP-dependent molecular chaperone HSP82/0.608
4ce2BO5ATP-dependent molecular chaperone HSP82/0.608
4fcr0TMHeat shock protein HSP 90-alpha/0.608
4jqlVJ6Heat shock protein HSP 90-alpha/0.607
1u0zRDCEndoplasmin/0.605
3ekrPY9Heat shock protein HSP 90-alpha/0.605
2byi2DDHeat shock protein HSP 90-alpha/0.601
1u2oNECEndoplasmin/0.595
2bz5AB4Heat shock protein HSP 90-alpha/0.595
4b7p9UNHeat shock protein HSP 90-alpha/0.595
2breKJ2ATP-dependent molecular chaperone HSP82/0.594
2xx213CATP-dependent molecular chaperone HSP82/0.591
3r4oFU3Heat shock protein HSP 90-alpha/0.591
4xclAGSHeat shock cognate 90 kDa protein/0.590
1yc34BCHeat shock protein HSP 90-alpha/0.586
4ivgANPTNF receptor-associated protein 1/0.585
3rlq3RQHeat shock protein HSP 90-alpha/0.581
1amwADPATP-dependent molecular chaperone HSP82/0.580
2xabVHDHeat shock protein HSP 90-alpha/0.580
4xdmGDMHeat shock cognate 90 kDa protein/0.580
2brcCT5ATP-dependent molecular chaperone HSP82/0.579
2xcmADPCytosolic heat shock protein 90/0.577
3r4nFU5Heat shock protein HSP 90-alpha/0.577
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.577
2o1uANPEndoplasmin/0.576
3t0zATPHeat shock protein HSP 90-alpha/0.573
2wepADPATP-dependent molecular chaperone HSP82/0.571
1uy7PU4Heat shock protein HSP 90-alpha/0.570
1yetGDMHeat shock protein HSP 90-alpha/0.569
1qy8RDIEndoplasmin/0.568
2fxsRDAATP-dependent molecular chaperone HSP82/0.567
2cgfP2NATP-dependent molecular chaperone HSP82/0.565
2xx413IATP-dependent molecular chaperone HSP82/0.563
3hyz42CHeat shock protein HSP 90-alpha/0.563
1uyePU9Heat shock protein HSP 90-alpha/0.562
3k981RCHeat shock protein HSP 90-alpha/0.562
4as94QSATP-dependent molecular chaperone HSP82/0.560
1yc14BCHeat shock protein HSP 90-alpha/0.559
1yc443PHeat shock protein HSP 90-alpha/0.558
3rlr3RRHeat shock protein HSP 90-alpha/0.557
2gqpPA7Endoplasmin/0.556
4asf62UATP-dependent molecular chaperone HSP82/0.556
4xc0ACPHeat shock cognate 90 kDa protein/0.556
3ekoPYUHeat shock protein HSP 90-alpha/0.555
1uymPU3Heat shock protein HSP 90-beta/0.554
2fypRDEEndoplasmin/0.553
3k974CDHeat shock protein HSP 90-alpha/0.551
1y4sADPChaperone protein HtpG/0.550
1u0yPA7Endoplasmin/0.549
4asg814ATP-dependent molecular chaperone HSP82/0.549
1uyfPU1Heat shock protein HSP 90-alpha/0.548
3ft8MOJHeat shock protein HSP 90-alpha/0.547
1qy5NECEndoplasmin/0.546
1uy8PU5Heat shock protein HSP 90-alpha/0.546
2bu8ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.546
4egkRDCHeat shock protein HSP 90-alpha/0.546
2vw5BC6ATP-dependent molecular chaperone HSP82/0.545
4nh82LCHeat shock protein HSP 90-alpha/0.545
2xhtC0YHeat shock protein HSP 90-alpha/0.544
2iwxM1SATP-dependent molecular chaperone HSP82/0.543
2wi6ZZ6Heat shock protein HSP 90-alpha/0.543
3whaWHAHeat shock protein HSP 90-alpha/0.543
3c11GDMATP-dependent molecular chaperone HSP82/0.542
1bgqRDCATP-dependent molecular chaperone HSP82/0.541
2yee2ECHeat shock protein HSP 90-alpha/0.541
3k99PFTHeat shock protein HSP 90-alpha/0.541
3qdd94MHeat shock protein HSP 90-alpha/0.540
4ce3L4VATP-dependent molecular chaperone HSP82/0.540
3b28B2XHeat shock protein HSP 90-alpha/0.539
3iedAN2HSP90/0.539
2hchN5AEndoplasmin/0.538
2ykiYKIHeat shock protein HSP 90-alpha/0.538
3d0bSNXHeat shock protein HSP 90-alpha/0.538
2bt0CT5Heat shock protein HSP 90-alpha/0.537
2o1vADPEndoplasmin/0.537
2wi72KLHeat shock protein HSP 90-alpha/0.537
2fwzH71Heat shock protein HSP 90-alpha/0.534
3inwJZBHeat shock protein HSP 90-alpha/0.534
4eftEFTHeat shock protein HSP 90-alpha/0.534
1yt0ADPEndoplasmin/0.533
2hg1N5OEndoplasmin/0.533
3o0iP54Heat shock protein HSP 90-alpha/0.533
2werRDCATP-dependent molecular chaperone HSP82/0.532
3hekBD0Heat shock protein HSP 90-alpha/0.532
1uy9PU6Heat shock protein HSP 90-alpha/0.531
1uykPUXHeat shock protein HSP 90-alpha/0.530
2gfdRDAEndoplasmin/0.529
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.529
1osfKOSHeat shock protein HSP 90-alpha/0.528
2iorADPChaperone protein HtpG/0.528
2qfoA13Heat shock protein HSP 90-alpha/0.527
2xhrC0PHeat shock protein HSP 90-alpha/0.526
1uydPU8Heat shock protein HSP 90-alpha/0.525
2esaGDMEndoplasmin/0.525
2fwyH64Heat shock protein HSP 90-alpha/0.525
2ykeYKEHeat shock protein HSP 90-alpha/0.525
3pehIBDEndoplasmin homolog, putative/0.525
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.524
1uy6PU3Heat shock protein HSP 90-alpha/0.524
3inxJZCHeat shock protein HSP 90-alpha/0.524
1uyiPUZHeat shock protein HSP 90-alpha/0.523
2qg2A91Heat shock protein HSP 90-alpha/0.523
2yi5YI5Heat shock protein HSP 90-alpha/0.523
3hz142CHeat shock protein HSP 90-alpha/0.521
2iwsNP4ATP-dependent molecular chaperone HSP82/0.519
2wi5ZZ5Heat shock protein HSP 90-alpha/0.516
2xjxXJXHeat shock protein HSP 90-alpha/0.516
2h55DZ8Heat shock protein HSP 90-alpha/0.514
2exlGDMEndoplasmin/0.510
1uycPU7Heat shock protein HSP 90-alpha/0.509
4efuEFUHeat shock protein HSP 90-alpha/0.508
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.507
3opdHIEHeat shock protein 83/0.505
3rlp3RPHeat shock protein HSP 90-alpha/0.505
2wi1ZZ2Heat shock protein HSP 90-alpha/0.504
2wi4ZZ4Heat shock protein HSP 90-alpha/0.501
2ykbYKBHeat shock protein HSP 90-alpha/0.501
2xjjL81Heat shock protein HSP 90-alpha/0.500
2ykjYKJHeat shock protein HSP 90-alpha/0.498
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.496
1nhhANPDNA mismatch repair protein MutL/0.495
2vwcBC2ATP-dependent molecular chaperone HSP82/0.495
2q8iRDC[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial2.7.11.20.493
3o6o94MHeat shock protein 83/0.493
1i58ADPChemotaxis protein CheA2.7.13.30.492
1i59ANPChemotaxis protein CheA2.7.13.30.492
1uyhPU0Heat shock protein HSP 90-alpha/0.492
3q5kD1UHeat shock protein 83-1/0.490
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.488
1z59ADPType 2 DNA topoisomerase 6 subunit B/0.486
2yejZZ3Heat shock protein HSP 90-alpha/0.485
2uwd2GGHeat shock protein HSP 90-alpha/0.484
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.483
3pejBC2Endoplasmin homolog, putative/0.482
4bqg50QHeat shock protein HSP 90-alpha/0.482
4egh0OYHeat shock protein HSP 90-alpha/0.482
2yk2YJWHeat shock protein HSP 90-alpha/0.481
2bu2ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.479
3mnrSD1Heat shock protein HSP 90-alpha/0.479
1i5aACPChemotaxis protein CheA2.7.13.30.478
2vcj2EQHeat shock protein HSP 90-alpha/0.478
2bsmBSMHeat shock protein HSP 90-alpha/0.477
1pvgANPDNA topoisomerase 25.99.1.30.476
1i58ACPChemotaxis protein CheA2.7.13.30.475
2qfoA51Heat shock protein HSP 90-alpha/0.474
3omuIBDHeat shock protein 83/0.474
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.471
2xx513NATP-dependent molecular chaperone HSP82/0.470
2zdxP4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.470
2yeiXQIHeat shock protein HSP 90-alpha/0.466
3h4lANPDNA mismatch repair protein PMS1/0.466
2vci2GJHeat shock protein HSP 90-alpha/0.464
2yi7BZ8Heat shock protein HSP 90-alpha/0.463
3sl2ATPSensor histidine kinase WalK/0.463
4nxvGDPMitochondrial dynamics protein MID51/0.463
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.462
2yjwYJWHeat shock protein HSP 90-alpha/0.462
1mx0ANPType 2 DNA topoisomerase 6 subunit B/0.460
2py3ACPFibroblast growth factor receptor 2/0.460
1e7qNAPGDP-L-fucose synthase/0.459
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.458
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.458
4wudANPDNA gyrase subunit B/0.458
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1i5cADPChemotaxis protein CheA2.7.13.30.457
2ye42FYHeat shock protein HSP 90-alpha/0.457
3hx4ANPCalmodulin-domain protein kinase 1/0.457
4fcq2N6Heat shock protein HSP 90-alpha/0.457
4hjfC2EGGDEF family protein/0.457
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.457
3zkbANPDNA gyrase subunit B/0.456
4gk4L90Ephrin type-A receptor 32.7.10.10.456
2qo9ANPEphrin type-A receptor 32.7.10.10.455
2bu9HFVIsopenicillin N synthase1.21.3.10.454
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.454
2pmdGNPTranslation initiation factor 2 subunit gamma/0.454
2uxoTACHTH-type transcriptional regulator TtgR/0.453
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.453
1thnADPAnti-sigma F factor/0.452
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.452
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.452
2uzdC85Cyclin-dependent kinase 22.7.11.220.452
2x7hPFNProstaglandin reductase 310.452
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.452
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
1cjkFOKAdenylate cyclase type 2/0.451
1cjkFOKAdenylate cyclase type 5/0.451
1z5aADPType 2 DNA topoisomerase 6 subunit B/0.451
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.451
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.451
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.451
2hkjRDCType 2 DNA topoisomerase 6 subunit B/0.450
2yi66QMHeat shock protein HSP 90-alpha/0.450
2cchATPCyclin-dependent kinase 22.7.11.220.449
2xjgXJGHeat shock protein HSP 90-alpha/0.449
1h1s4SPCyclin-dependent kinase 22.7.11.220.448
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.447
1vyw292Cyclin-dependent kinase 22.7.11.220.447
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.447
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.447
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.447
1cjtFOKAdenylate cyclase type 2/0.446
1cjtFOKAdenylate cyclase type 5/0.446
1i3mUD1UDP-glucose 4-epimerase/0.446
3fr4F8AFatty acid-binding protein, adipocyte/0.446
4awq592Heat shock protein HSP 90-alpha/0.446
4prvADPDNA gyrase subunit B/0.446
2wi2ZZ3Heat shock protein HSP 90-alpha/0.445
2xvdAS6Ephrin type-B receptor 42.7.10.10.445
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.445
4awp99AHeat shock protein HSP 90-alpha/0.445
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.445
4wucANPDNA gyrase subunit B/0.445
1hdrNADDihydropteridine reductase1.5.1.340.444
1i59ADPChemotaxis protein CheA2.7.13.30.444
1p0hACOMycothiol acetyltransferase2.3.1.1890.444
1sduMK1Gag-Pol polyprotein3.4.23.160.444
1yb5NAPQuinone oxidoreductase1.6.5.50.444
2zjwREFCasein kinase II subunit alpha2.7.11.10.444
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.444
4g2fC07Ephrin type-A receptor 32.7.10.10.444
1dhrNADDihydropteridine reductase1.5.1.340.443
1finATPCyclin-dependent kinase 22.7.11.220.443
2hcdBIVVitamin D3 receptor A/0.443
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.443
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.443
1ezvUQ6Cytochrome b/0.442
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2hog710Serine/threonine-protein kinase Chk12.7.11.10.442
2itpAEEEpidermal growth factor receptor2.7.10.10.442
2q61SF1Peroxisome proliferator-activated receptor gamma/0.442
2qhyMZ1Gag-Pol polyprotein/0.442
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
4uyf73BBromodomain-containing protein 2/0.442
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.441
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.441
3il1B5DGlutamate receptor 2/0.441
3lqfNADGalactitol dehydrogenase/0.441
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3s1dZIRCytokinin dehydrogenase 11.5.99.120.441
3te4ACODopamine N-acetyltransferase/0.441
4gk3L87Ephrin type-A receptor 32.7.10.10.441
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
4nmbFADBifunctional protein PutA/0.441
1dirNADDihydropteridine reductase1.5.1.340.440
1ke6LS2Cyclin-dependent kinase 22.7.11.220.440
2fziDH3Dihydrofolate reductase1.5.1.30.440
2q59240Peroxisome proliferator-activated receptor gamma/0.440
3rpv26ZCyclin-dependent kinase 22.7.11.220.440
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440