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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xir00JVascular endothelial growth factor receptor 22.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xir00JVascular endothelial growth factor receptor 22.7.10.11.000
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.654
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.616
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.614
3efl706Vascular endothelial growth factor receptor 22.7.10.10.614
3hng8STVascular endothelial growth factor receptor 12.7.10.10.614
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.606
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.597
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.589
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.587
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.577
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.576
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.575
3eta351Insulin receptor2.7.10.10.565
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.554
3ctj320Hepatocyte growth factor receptor2.7.10.10.553
2og81N8Tyrosine-protein kinase Lck2.7.10.20.552
3ce31FNHepatocyte growth factor receptor2.7.10.10.551
2hyySTITyrosine-protein kinase ABL12.7.10.20.549
4eyjN61Mitogen-activated protein kinase 132.7.11.240.544
3hv5R24Mitogen-activated protein kinase 14/0.543
4o2z046Mitogen-activated protein kinase/0.541
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.536
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.536
1iepSTITyrosine-protein kinase ABL12.7.10.20.534
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.533
4eevL1XHepatocyte growth factor receptor2.7.10.10.531
4kaoKAOFocal adhesion kinase 12.7.10.20.529
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.521
4qrc0LIFibroblast growth factor receptor 42.7.10.10.519
4aa0AA0Mitogen-activated protein kinase 14/0.511
3kq7KQ7Mitogen-activated protein kinase 14/0.510
3tubFPUTyrosine-protein kinase SYK2.7.10.20.510
3ds6A17Mitogen-activated protein kinase 14/0.504
3gcsBAXMitogen-activated protein kinase 14/0.504
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.501
2p4iMR9Angiopoietin-1 receptor2.7.10.10.493
3iw8HIZMitogen-activated protein kinase 14/0.490
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.490
3lfbZ87Mitogen-activated protein kinase 14/0.485
1gypNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.484
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.482
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.481
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.480
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.480
3h0aD30Peroxisome proliferator-activated receptor gamma/0.478
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.477
4l9q9TPSerum albumin/0.474
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.471
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.468
2obyNAPQuinone oxidoreductase PIG310.467
3wmxNADNAD dependent epimerase/dehydratase/0.466
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
1ml3NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.465
1osvCHCBile acid receptor/0.465
4b7xNAPProbable oxidoreductase/0.465
4nka2K7Fibroblast growth factor receptor 1/0.465
3icrCOACoenzyme A disulfide reductase/0.463
4i3vNADAldehyde dehydrogenase (NAD+)/0.463
3ol5SAWCamphor 5-monooxygenase1.14.15.10.462
3t2yFADSulfide-quinone reductase/0.462
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.461
3p6pA6BCamphor 5-monooxygenase1.14.15.10.461
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.461
1v5eFADPyruvate oxidase/0.460
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.460
2zb3NDPProstaglandin reductase 21.3.1.480.460
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.460
2y00Y01Beta-1 adrenergic receptor/0.459
3g70A5TRenin3.4.23.150.459
3p99LNPLanosterol 14-alpha-demethylase/0.459
4jv618FRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.459
4q72FADBifunctional protein PutA/0.459
4qvtACOAcetyltransferase YpeA2.3.10.459
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.458
2ozuACOHistone acetyltransferase KAT6A/0.458
3dl9V2HVitamin D 25-hydroxylase/0.458
3syiFADSulfide-quinone reductase/0.458
3dmtNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.457
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.457
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.457
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.456
1ot7IU5Bile acid receptor/0.456
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.456
3t2zFADSulfide-quinone reductase/0.456
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.456
4g3jVNTLanosterol 14-alpha-demethylase/0.456
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.456
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.456
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.456
5lc1NADL-threonine 3-dehydrogenase/0.456
1yb5NAPQuinone oxidoreductase1.6.5.50.455
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3l8p0CEAngiopoietin-1 receptor2.7.10.10.455
3w2rW2REpidermal growth factor receptor2.7.10.10.455
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.454
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.454
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3ajrNADNDP-sugar epimerase/0.454
3p6mDSOCamphor 5-monooxygenase1.14.15.10.454
3tmz06XCytochrome P450 2B41.14.14.10.454
4xyeNADFormate dehydrogenase/0.454
1khrCOAStreptogramin A acetyltransferase2.3.10.453
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
2ebaFADPutative glutaryl-CoA dehydrogenase/0.453
2jd0NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.453
3p6nDSOCamphor 5-monooxygenase1.14.15.10.453
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.453
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.453
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.453
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.452
3gw9VNILanosterol 14-alpha-demethylase/0.452
3p6oETGCamphor 5-monooxygenase1.14.15.10.452
3sh0SAXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.452
2y05NAPProstaglandin reductase 1/0.451
2zb1GK4Mitogen-activated protein kinase 14/0.451
3ggpNADPrephenate dehydrogenase/0.451
3jynNDPQuinone oxidoreductase/0.451
3tvuB37Acetyl-CoA carboxylase/0.451
3v9y24LPeroxisome proliferator-activated receptor gamma/0.451
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4hee14RPeroxisome proliferator-activated receptor gamma/0.451
1ot7CHCBile acid receptor/0.450
1sbyNADAlcohol dehydrogenase1.1.1.10.450
2y01Y01Beta-1 adrenergic receptor/0.450
2y03Y01Beta-1 adrenergic receptor/0.450
3h0sB38Acetyl-CoA carboxylase/0.450
3sz0FADSulfide-quinone reductase/0.450
3w2cN15Aurora kinase A2.7.11.10.450
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.450
2jizSTLATP synthase subunit alpha, mitochondrial/0.449
2jizSTLATP synthase subunit gamma, mitochondrial/0.449
2q61SF1Peroxisome proliferator-activated receptor gamma/0.449
2qjySMACytochrome b/0.449
2znnS44Peroxisome proliferator-activated receptor alpha/0.449
3lshFADPyranose 2-oxidase/0.449
3okfNAD3-dehydroquinate synthase4.2.3.40.449
4qe6JN3Bile acid receptor/0.449
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.449
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.449
1qxsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.448
1tdkFADL-amino-acid oxidase1.4.3.20.448
1xddAAYIntegrin alpha-L/0.448
1xkdNAPIsocitrate dehydrogenase [NADP]/0.448
2bl4NADLactaldehyde reductase1.1.1.770.448
2djiFADPyruvate oxidase/0.448
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.448
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.448
1znqNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.447
2bi4NADLactaldehyde reductase1.1.1.770.447
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.447
2y02Y01Beta-1 adrenergic receptor/0.447
5jtbZMAAdenosine receptor A2a/0.447
1lriCLRBeta-elicitin cryptogein/0.446
1uumAFIDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.446
2apgFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.446
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.446
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
3tdaPN0Cytochrome P450 2D6/0.446
3w8wFADPutative FAD-dependent oxygenase EncM/0.446
4nr42LKCREB-binding protein/0.446
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.446
2c0cNAPProstaglandin reductase 310.445
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.445
2fzwNADAlcohol dehydrogenase class-31.1.1.10.445
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
2yltFADPhenylacetone monooxygenase1.14.13.920.445
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3h65I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.445
3icsCOACoenzyme A disulfide reductase/0.445
3mg3ECHOrange carotenoid-binding protein/0.445
4anbYQYDual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
4cgpMYAGlycylpeptide N-tetradecanoyltransferase/0.445
5k2dZMAAdenosine receptor A2a/0.445
1ie4T44Transthyretin/0.444
1jq5NADGlycerol dehydrogenase1.1.1.60.444
3ak4NADNADH-dependent quinuclidinone reductase/0.444
3t8xT8XT-cell surface glycoprotein CD1b/0.444
4j6dTESCytochrome P450 monooxygenase/0.444
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.444
5dbfNDPIridoid synthase1.3.1.990.444
1dg8NDPDihydrofolate reductase1.5.1.30.443
2e48FADD-amino-acid oxidase1.4.3.30.443
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.443
2q9fC3SCholesterol 24-hydroxylase/0.443
2rm2W43Genome polyprotein/0.443
2vnaNAPProstaglandin reductase 21.3.1.480.443
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.443
3ea4FABAcetolactate synthase, chloroplastic2.2.1.60.443
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.443
3t2kFADSulfide-quinone reductase/0.443
3uvqFS8Mitogen-activated protein kinase 14/0.443
4itbNDPSuccinate-semialdehyde dehydrogenase/0.443
4j4bNAIUncharacterized protein/0.443
4oze24GUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.443
2dteNAIGlucose 1-dehydrogenase related protein/0.442
3o3nIRC(R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit/0.442
3qwbNDPProbable quinone oxidoreductase1.6.5.50.442
3zk5Z18Cytochrome P450 monooxygenase PikC/0.442
4cnjFADL-amino acid oxidase/0.442
4ekg0QJHistone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.442
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.442
5ag7MYAGlycylpeptide N-tetradecanoyltransferase/0.442
5g3sFDAFlavin-dependent L-tryptophan oxidase VioA/0.442
1mg5NAIAlcohol dehydrogenase1.1.1.10.441
1reoFADL-amino-acid oxidase1.4.3.20.441
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.441
2go4TUXUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.441
2nuaCOASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.441
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.441
2wetFADTryptophan 5-halogenase/0.441
2y0mACOHistone acetyltransferase KAT8/0.441
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.441
3cxhSMACytochrome b/0.441
4ele31IDihydrofolate reductase/0.441
4q73FADBifunctional protein PutA/0.441
5bp9SAHPutative methyltransferase protein/0.441
1mjaCOAHistone acetyltransferase ESA1/0.440
1ppjSMACytochrome b/0.440
1pr9NAPL-xylulose reductase1.1.1.100.440
1s7gNADNAD-dependent protein deacylase 2/0.440
2aibERGBeta-elicitin cinnamomin/0.440
2g82NADGlyceraldehyde-3-phosphate dehydrogenase/0.440
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.440
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.440
2ylrFADPhenylacetone monooxygenase1.14.13.920.440
3zos0LIEpithelial discoidin domain-containing receptor 12.7.10.10.440
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4ez8DHFThymidylate synthase2.1.1.450.440
4isk1JYThymidylate synthase/0.440
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.440
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.440