sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xhr | C0P | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.570 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.553 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.549 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.546 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.533 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.532 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.529 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.527 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.515 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.514 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 1qy8 | RDI | Endoplasmin | / | 0.509 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 1ysz | NEC | Endoplasmin | / | 0.498 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.494 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 1u0z | RDC | Endoplasmin | / | 0.491 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.487 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.486 | |
| 1qy5 | NEC | Endoplasmin | / | 0.486 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.483 | |
| 2gfd | RDA | Endoplasmin | / | 0.481 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.481 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.478 | |
| 3ied | AN2 | HSP90 | / | 0.477 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.477 | |
| 1u0y | PA7 | Endoplasmin | / | 0.476 | |
| 2hg1 | N5O | Endoplasmin | / | 0.476 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.476 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.475 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 2hch | N5A | Endoplasmin | / | 0.474 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.468 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.464 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 1u2o | NEC | Endoplasmin | / | 0.457 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.452 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.450 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.450 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.450 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.449 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.448 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.448 | |
| 2gqp | PA7 | Endoplasmin | / | 0.448 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.445 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.445 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.445 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.444 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.443 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.442 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.442 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2fyp | RDE | Endoplasmin | / | 0.441 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.441 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.441 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.440 |