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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.11.000
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.564
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.554
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.553
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.549
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.544
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.540
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.537
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.530
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.527
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.526
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.523
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.520
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.518
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.515
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.514
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.514
2hog710Serine/threonine-protein kinase Chk12.7.11.10.513
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.511
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.510
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.509
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.507
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.506
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.506
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.505
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.505
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.502
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.500
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.500
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.499
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.498
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.498
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.497
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.497
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.495
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.495
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.494
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.492
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.491
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.491
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.490
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.489
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.489
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.488
4ji91M3Tyrosine-protein kinase JAK2/0.488
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.487
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.487
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.486
4fv6E57Mitogen-activated protein kinase 12.7.11.240.486
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.485
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.485
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.484
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.483
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.482
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.481
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.480
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.480
3i60E86Mitogen-activated protein kinase 12.7.11.240.479
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.479
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.477
4fv9E71Mitogen-activated protein kinase 12.7.11.240.477
1zrzBI1Protein kinase C iota type2.7.11.130.476
2wxvWXVCyclin-dependent kinase 22.7.11.220.475
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.475
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.475
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.474
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.474
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.473
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.473
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.471
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.471
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.471
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.470
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.470
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.469
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.469
3a62STURibosomal protein S6 kinase beta-12.7.11.10.469
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.469
4ehzJAKTyrosine-protein kinase JAK1/0.468
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.468
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.468
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.467
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.467
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.466
1rfuADPPyridoxal kinase2.7.1.350.466
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.466
4fod0UVALK tyrosine kinase receptor2.7.10.10.466
3t8oATPRhodopsin kinase/0.465
4gmy0X5Tyrosine-protein kinase JAK2/0.465
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.465
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.464
4jia1K3Tyrosine-protein kinase JAK2/0.464
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.463
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.463
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.463
2qo7ANPEphrin type-A receptor 32.7.10.10.462
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.462
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.462
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.462
2qo9ANPEphrin type-A receptor 32.7.10.10.461
2ojj82AMitogen-activated protein kinase 12.7.11.240.460
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.460
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.459
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.459
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.459
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.459
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.459
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.459
1pjkANPCasein kinase II subunit alpha2.7.11.10.458
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.458
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.458
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.457
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.457
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.457
3c4xATPRhodopsin kinase/0.457
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.456
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.456
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.455
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
2j0m4STFocal adhesion kinase 12.7.10.20.454
4aqc88ATyrosine-protein kinase JAK2/0.454
2j0lANPFocal adhesion kinase 12.7.10.20.453
2vd5BI8Myotonin-protein kinase2.7.11.10.453
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.453
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.452
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.452
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.452
3zh8C58Protein kinase C iota type2.7.11.130.452
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.451
4aguD15Cyclin-dependent kinase-like 1/0.451
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.450
3zep1NXTyrosine-protein kinase JAK32.7.10.20.450
1bwsNDPGDP-L-fucose synthase/0.449
2itvANPEpidermal growth factor receptor2.7.10.10.449
2qoqANPEphrin type-A receptor 32.7.10.10.449
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.449
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.449
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.449
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.449
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.448
4a99FADTetX family tetracycline inactivation enzyme/0.448
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.448
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.448
4qo9627Serine/threonine-protein kinase 242.7.11.10.448
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.447
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.447
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.447
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.447
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.447
3u9eCOALmo1369 protein/0.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.446
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
3zuyTCHTransporter/0.446
4b99R4LMitogen-activated protein kinase 72.7.11.240.446
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.446
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.446
1rfvADPPyridoxal kinase2.7.1.350.445
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.445
2itnANPEpidermal growth factor receptor2.7.10.10.445
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
3eyhIZATyrosine-protein kinase JAK1/0.445
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.445
4fv8E63Mitogen-activated protein kinase 12.7.11.240.445
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.445
4qmlANPSerine/threonine-protein kinase 242.7.11.10.445
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.444
1tvoFRZMitogen-activated protein kinase 12.7.11.240.444
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.444
2fy4COACholine O-acetyltransferase2.3.1.60.444
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.444
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.444
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.444
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.443
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.443
4a6cQG9Gag-Pol polyprotein3.4.23.160.443
4gk3L87Ephrin type-A receptor 32.7.10.10.443
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
5e8ySTUTGF-beta receptor type-22.7.11.300.443
1bygSTUTyrosine-protein kinase CSK/0.442
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.442
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.442
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.442
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.442
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
2wipP49Cyclin-dependent kinase 22.7.11.220.441
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.441
4xgxADPFAD:protein FMN transferase/0.441
2c4g514Cyclin-dependent kinase 22.7.11.220.440
2npaMMBPeroxisome proliferator-activated receptor alpha/0.440
2xyuQ9GEphrin type-A receptor 42.7.10.10.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.440
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.440
5dr9SKEAurora kinase A2.7.11.10.440