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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2x9vTMQPteridine reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2x9vTMQPteridine reductase/1.000
3jqgAX6Pteridine reductase, putative/0.612
3jqbDX6Pteridine reductase, putative/0.599
3jq7DX2Pteridine reductase, putative/0.573
2vz0D64Pteridine reductase/0.566
3jq8DX3Pteridine reductase, putative/0.564
3jq9AX1Pteridine reductase, putative/0.562
3jq6DX1Pteridine reductase, putative/0.547
3bmcFOLPteridine reductase/0.546
3mcvMCVPteridine reductase/0.537
3bmqAX5Pteridine reductase/0.526
2yhuWHFPteridine reductase/0.513
1p33MTXPteridine reductase 11.5.1.330.509
2x9gLYAPteridine reductase/0.509
1mxfMTXPutative pteridine reductase 2/0.486
3bmnAX3Pteridine reductase/0.483
3h4vDVPPteridine reductase 11.5.1.330.482
2wd7VGDPteridine reductase/0.481
2bfmTOPPteridine reductase 11.5.1.330.479
2bf7HBIPteridine reductase 11.5.1.330.474
1e92HBIPteridine reductase 11.5.1.330.470
2x9nAX3Pteridine reductase/0.464
2bfpH4BPteridine reductase 11.5.1.330.463
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.448
1e7wMTXPteridine reductase 11.5.1.330.443
2io6330Wee1-like protein kinase2.7.10.20.442
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.442
2z2w770Wee1-like protein kinase2.7.10.20.440