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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2x9gLYAPteridine reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2x9gLYAPteridine reductase/1.000
3bmcFOLPteridine reductase/0.596
3jqbDX6Pteridine reductase, putative/0.587
3mcvMCVPteridine reductase/0.580
3jq9AX1Pteridine reductase, putative/0.568
3jqgAX6Pteridine reductase, putative/0.558
3bmqAX5Pteridine reductase/0.546
3jq7DX2Pteridine reductase, putative/0.544
2vz0D64Pteridine reductase/0.543
2yhuWHFPteridine reductase/0.540
1p33MTXPteridine reductase 11.5.1.330.536
3jq8DX3Pteridine reductase, putative/0.521
2wd7VGDPteridine reductase/0.509
2x9vTMQPteridine reductase/0.503
3bmnAX3Pteridine reductase/0.487
3jq6DX1Pteridine reductase, putative/0.482
2x9nAX3Pteridine reductase/0.478
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
1e7wMTXPteridine reductase 11.5.1.330.452
1mxfMTXPutative pteridine reductase 2/0.441