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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2x23TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2x23TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.591
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.536
4j6cSTRCytochrome P450 monooxygenase/0.529
2ol4JPNEnoyl-ACP reductase/0.508
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.506
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.501
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.495
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.492
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.486
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.485
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.485
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.484
2z3uCRRCytochrome P450/0.483
4j6dTESCytochrome P450 monooxygenase/0.483
4r20AERCytochrome P450 family 17 polypeptide 2/0.483
4rv9SAHD-mycarose 3-C-methyltransferase/0.482
2e48FADD-amino-acid oxidase1.4.3.30.481
4nc3ERM5-hydroxytryptamine receptor 2B/0.480
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.479
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.479
2dw4FADLysine-specific histone demethylase 1A10.478
4g3jVNTLanosterol 14-alpha-demethylase/0.478
4nb6444Nuclear receptor ROR-gamma/0.478
3gc8B45Mitogen-activated protein kinase 112.7.11.240.476
4ez8DHFThymidylate synthase2.1.1.450.476
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.475
3gw9VNILanosterol 14-alpha-demethylase/0.475
3ol5SAWCamphor 5-monooxygenase1.14.15.10.475
4b5pACOAlpha-tubulin N-acetyltransferase 1/0.475
3nx4NAPPutative oxidoreductase/0.474
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.473
3h0aD30Peroxisome proliferator-activated receptor gamma/0.472
1hb1OCVIsopenicillin N synthase1.21.3.10.471
3dxjNE6DNA-directed RNA polymerase subunit beta/0.471
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.471
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.470
3wleNAD(R)-specific carbonyl reductase/0.470
4fnyI3KALK tyrosine kinase receptor2.7.10.10.470
1bk0ACVIsopenicillin N synthase1.21.3.10.469
1qiqACCIsopenicillin N synthase1.21.3.10.469
1jujLYAThymidylate synthase2.1.1.450.468
2ykeYKEHeat shock protein HSP 90-alpha/0.468
3p6nDSOCamphor 5-monooxygenase1.14.15.10.468
3q0uLL3HTH-type transcriptional regulator EthR/0.468
4j6bPLOCytochrome P450 monooxygenase/0.468
2ykcYKCHeat shock protein HSP 90-alpha/0.467
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.467
2hm9TRRDihydrofolate reductase1.5.1.30.466
3tdaPN0Cytochrome P450 2D6/0.466
1n4hREANuclear receptor ROR-beta/0.465
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.465
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
4iaq2GM5-hydroxytryptamine receptor 1B/0.465
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.465
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
5dp2NAPCurF/0.465
3p6mDSOCamphor 5-monooxygenase1.14.15.10.464
2z78H86Geranylgeranyl pyrophosphate synthase/0.463
1cboFADCholesterol oxidase1.1.3.60.462
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.462
2ykiYKIHeat shock protein HSP 90-alpha/0.462
3g1mRF3HTH-type transcriptional regulator EthR/0.462
1diuBDMDihydrofolate reductase1.5.1.30.461
2r3yVAL_TYR_TRP_PHESerine endoprotease DegS3.4.21.1070.461
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.461
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.461
1ie8KH1Vitamin D3 receptor/0.460
1sezFADProtoporphyrinogen oxidase, mitochondrial1.3.3.40.460
1zsnTN2Enoyl-ACP reductase/0.460
2c7xNRBCytochrome P450 monooxygenase PikC/0.460
2ykbYKBHeat shock protein HSP 90-alpha/0.460
2ykjYKJHeat shock protein HSP 90-alpha/0.460
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.460
4iarERM5-hydroxytryptamine receptor 1B/0.460
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.460
2o4jVD4Vitamin D3 receptor/0.459
3w8wFADPutative FAD-dependent oxygenase EncM/0.459
4jbtASDCytochrome P450 monooxygenase/0.459
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
5l7dCLRSmoothened homolog/0.459
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.458
3q0vLL4HTH-type transcriptional regulator EthR/0.458
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.458
3w0iO11Vitamin D3 receptor/0.458
3zoiM2WIsopenicillin N synthase1.21.3.10.458
2o4rVD5Vitamin D3 receptor/0.457
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
3cx5SMACytochrome b/0.457
3gdsVAL_TYR_TYR_PHESerine endoprotease DegS3.4.21.1070.457
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.457
3p6oETGCamphor 5-monooxygenase1.14.15.10.457
3t2zFADSulfide-quinone reductase/0.457
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.457
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.456
1uyfPU1Heat shock protein HSP 90-alpha/0.456
1w06W05Isopenicillin N synthase1.21.3.10.456
2j83BATUlilysin3.4.240.456
2y60M8FIsopenicillin N synthase1.21.3.10.456
2yk2YJXHeat shock protein HSP 90-alpha/0.456
3a1l2CCCytochrome P450/0.456
3jynNDPQuinone oxidoreductase/0.456
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.456
4nieNBHNuclear receptor ROR-gamma/0.456
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.456
4qe6JN3Bile acid receptor/0.456
7catNDPCatalase1.11.1.60.456
1blzACVIsopenicillin N synthase1.21.3.10.455
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2uxoTACHTH-type transcriptional regulator TtgR/0.455
3gkiCLRNiemann-Pick C1 protein/0.455
3sfi3SFHTH-type transcriptional regulator EthR/0.455
4jlj1NMDeoxycytidine kinase2.7.1.740.455
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.454
2uxxFAJLysine-specific histone demethylase 1A10.454
3vt45YIVitamin D3 receptor/0.454
4u2lSFDCholesterol oxidase1.1.3.60.454
3o8hO8HHTH-type transcriptional regulator EthR/0.453
3w2cN15Aurora kinase A2.7.11.10.453
3gkjHC3Niemann-Pick C1 protein/0.452
3o8gO8GHTH-type transcriptional regulator EthR/0.452
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.452
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.452
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.452
4nh82LCHeat shock protein HSP 90-alpha/0.452
1uydPU8Heat shock protein HSP 90-alpha/0.451
2r6jNDPEugenol synthase 11.1.1.3180.451
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.451
3t2kFADSulfide-quinone reductase/0.451
3vt5YI2Vitamin D3 receptor/0.451
3zkyWT4Isopenicillin N synthase1.21.3.10.451
4elb34RDihydrofolate reductase/0.451
4g7gVFVLanosterol 14-alpha-demethylase/0.451
4nmkNAPAldehyde dehydrogenase/0.451
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.451
2igoFADPyranose 2-oxidase/0.450
2zb3NDPProstaglandin reductase 21.3.1.480.450
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
4fgrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.450
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.450
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.450
1re9DSOCamphor 5-monooxygenase1.14.15.10.449
2hkoFADLysine-specific histone demethylase 1A10.449
2zl9VDAVitamin D3 receptor/0.449
3hz5Z64Heat shock protein HSP 90-alpha/0.449
4at0FADPossible succinate dehydrogenase/0.449
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.449
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.449
4ucnMYAGlycylpeptide N-tetradecanoyltransferase/0.449
5a28MYAGlycylpeptide N-tetradecanoyltransferase/0.449
1hb3SCVIsopenicillin N synthase1.21.3.10.448
1sqvUHDCytochrome b/0.448
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.448
2iviACWIsopenicillin N synthase1.21.3.10.448
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.448
2vbpVB1Isopenicillin N synthase1.21.3.10.448
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.448
3vt65YIVitamin D3 receptor/0.448
3vt9YI4Vitamin D3 receptor/0.448
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.448
4o701QKBromodomain-containing protein 4/0.448
4yntFDAGlucose oxidase, putative/0.448
1kt3RTLRetinol-binding protein 4/0.447
1oc1ASVIsopenicillin N synthase1.21.3.10.447
1umlFR4Adenosine deaminase3.5.4.40.447
1xuoLA1Integrin alpha-L/0.447
1yc2NADNAD-dependent protein deacylase 2/0.447
2hbhXE4Vitamin D3 receptor A/0.447
3cib314Beta-secretase 13.4.23.460.447
3nj8NJ8Enoyl-acyl carrier reductase/0.447
3vtdTKDVitamin D3 receptor/0.447
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.447
4ce0SAHProbable O-methyltransferase/0.447
4i8vBHFCytochrome P450 1A11.14.14.10.447
4r21STRCytochrome P450 family 17 polypeptide 2/0.447
1felFENRetinol-binding protein 4/0.446
1fmlRTLRetinol dehydratase/0.446
1o6rR19Squalene--hopene cyclase4.2.1.1290.446
1ppjANYCytochrome b/0.446
1pqc444Oxysterols receptor LXR-beta/0.446
1s0zEB1Vitamin D3 receptor/0.446
1uyePU9Heat shock protein HSP 90-alpha/0.446
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2q9fC3SCholesterol 24-hydroxylase/0.446
2vbdV10Isopenicillin N synthase1.21.3.10.446
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.446
3kpkFADSulfide-quinone reductase/0.446
3p99LNPLanosterol 14-alpha-demethylase/0.446
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
5a2yUTPMitochondrial poly(A) polymerase/0.446
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2q4wFADCytokinin dehydrogenase 71.5.99.120.445
2y6fM9FIsopenicillin N synthase1.21.3.10.445
3mnrSD1Heat shock protein HSP 90-alpha/0.445
3p6pA6BCamphor 5-monooxygenase1.14.15.10.445
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4ib4ERM5-hydroxytryptamine receptor 2B/0.445
5envNADAlcohol dehydrogenase 11.1.1.10.445
3reyXACAdenosine receptor A2a/0.445
1ci7CB3Thymidylate synthase2.1.1.450.444
1lriCLRBeta-elicitin cryptogein/0.444
1rkgVD1Vitamin D3 receptor/0.444
2hcdBIVVitamin D3 receptor A/0.444
2r0cFADPutative FAD-monooxygenase/0.444
2wuuNHWGlycylpeptide N-tetradecanoyltransferase/0.444
3ad9NADSubunit alpha of sarocosine oxidase/0.444
3bfa9ODOdorant binding protein ASP1/0.444
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.444
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3vtbTKAVitamin D3 receptor/0.444
4bhw01KHistone acetyltransferase p300/0.444
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.444
1mznBM6Retinoic acid receptor RXR-alpha/0.443
1n83CLRNuclear receptor ROR-alpha/0.443
1uzwCDHIsopenicillin N synthase1.21.3.10.443
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.443
2om9AJAPeroxisome proliferator-activated receptor gamma/0.443
3abaFLICytochrome P450/0.443
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3cxhSMACytochrome b/0.443
3ds6A17Mitogen-activated protein kinase 14/0.443
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3is9AC7Gag-Pol polyprotein2.7.7.490.443
3l70JZVCytochrome b/0.443
3qm4PN0Cytochrome P450 2D6/0.443
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.443
4elf35IDihydrofolate reductase/0.443
4q0a4OAVitamin D3 receptor A/0.443
5a3bAPRSIR2 family protein/0.443
1dgfNDPCatalase1.11.1.60.442
1fcx184Retinoic acid receptor gamma/0.442
1fcy564Retinoic acid receptor gamma/0.442
1nq7ARLNuclear receptor ROR-beta/0.442
1zdwFLVPrenyltransferase/0.442
2x9dITCTetracycline repressor protein class D/0.442
3pm0BHFCytochrome P450 1B1/0.442
3vt8YI3Vitamin D3 receptor/0.442
4jx1CAHCamphor 5-monooxygenase1.14.15.10.442
5uviZMAAdenosine receptor A2a/0.442
1cbsREACellular retinoic acid-binding protein 2/0.441
1fd0254Retinoic acid receptor gamma/0.441
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.441
1ndzFR5Adenosine deaminase3.5.4.40.441
1rf9DBRCamphor 5-monooxygenase1.14.15.10.441
2aibERGBeta-elicitin cinnamomin/0.441
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.441
2bxnIDBSerum albumin/0.441
2dqsTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
2hasC3OVitamin D3 receptor/0.441
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.441
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.441
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4w6z8IDAlcohol dehydrogenase 11.1.1.10.441
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.441
1ek2CDUBifunctional epoxide hydrolase 2/0.440
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.440
2bu9HFVIsopenicillin N synthase1.21.3.10.440
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
3p3zP3ZPutative cytochrome P450/0.440
3qlwN22Dihydrofolate reductase1.5.1.30.440
4awo99BHeat shock protein HSP 90-alpha/0.440
4ele31IDihydrofolate reductase/0.440
4iteTEYVitamin D3 receptor/0.440
4pztSOPHistone acetyltransferase p300/0.440
4xbfFADLysine-specific histone demethylase 1A10.440
5k2dZMAAdenosine receptor A2a/0.440