scPDB - Distribution of Binding site Similarity values of 2x06 entry / Site 8

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2x06	NAD	L-sulfolactate dehydrogenase

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2x06	NAD	L-sulfolactate dehydrogenase	/	1.000
1vbi	NAD	Malate/L-lactate dehydrogenase family protein	/	0.510
3in6	FMN	Uncharacterized protein	/	0.481
4bft	ZVT	Pantothenate kinase	2.7.1.33	0.481
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.481
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.477
3u9f	CLM	Chloramphenicol acetyltransferase	2.3.1.28	0.475
1xdd	AAY	Integrin alpha-L	/	0.473
3qe2	FMN	NADPH--cytochrome P450 reductase	/	0.472
4a87	NAR	Major pollen allergen Bet v 1-A	/	0.472
3uoy	FAD	2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase	1.14.13.160	0.469
2ea2	F77	Methionine aminopeptidase 2	/	0.467
3gw9	VNI	Lanosterol 14-alpha-demethylase	/	0.467
3h3q	H13	Collagen type IV alpha-3-binding protein	/	0.467
1eio	GCH	Gastrotropin	/	0.466
3q43	D66	M1 family aminopeptidase	3.4.11	0.466
4bfw	ZVW	Pantothenate kinase	2.7.1.33	0.464
2x9d	ITC	Tetracycline repressor protein class D	/	0.463
3dys	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.463
1iol	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.461
2gev	COK	Pantothenate kinase	2.7.1.33	0.460
3dyl	PCG	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.460
2whq	HI6	Acetylcholinesterase	3.1.1.7	0.459
3em0	CHD	Fatty acid-binding protein 6, ileal (gastrotropin)	/	0.459
4udq	FAD	5-(hydroxymethyl)furfural oxidase	/	0.459
5irn	ADP	Nucleotide binding oligomerization domain containing 2	/	0.458
1ps9	MDE	2,4-dienoyl-CoA reductase	1.3.1.34	0.457
2hyd	ADP	Putative multidrug export ATP-binding/permease protein SAV1866	3.6.3	0.457
1kbo	340	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.456
2gv8	NDP	Thiol-specific monooxygenase	1.14.13	0.456
3qfr	FMN	NADPH--cytochrome P450 reductase	/	0.456
4fxy	0W2	Neurolysin, mitochondrial	3.4.24.16	0.456
1siq	FAD	Glutaryl-CoA dehydrogenase, mitochondrial	1.3.8.6	0.455
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.455
4g2l	0WL	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.455
4zzi	1NS	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.455
3h3r	14H	Collagen type IV alpha-3-binding protein	/	0.454
1teh	NAD	Alcohol dehydrogenase class-3	1.1.1.1	0.453
3br3	ET	HTH-type transcriptional regulator QacR	/	0.453
3pqb	VGP	Putative oxidoreductase	/	0.453
3qgf	46F	Genome polyprotein	2.7.7.48	0.453
1gg5	E09	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.452
1u1g	BBB	Uridine phosphorylase	2.4.2.3	0.452
3h06	VBP	Glutamate receptor 2	/	0.452
3jsw	JAR	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.452
3jpu	TY4	Transcriptional activator protein LasR	/	0.451
3ts1	TYA	Tyrosine--tRNA ligase	6.1.1.1	0.451
4g3j	VNT	Lanosterol 14-alpha-demethylase	/	0.451
3af1	GDP	Pantothenate kinase	2.7.1.33	0.450
3dy8	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.450
3pm1	ET	HTH-type transcriptional regulator QacR	/	0.450
3wag	TYD	Glycosyltransferase	/	0.450
2hrc	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.449
2vig	FAD	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	1.3.8.1	0.449
3e8x	NAP	BH1520 protein	/	0.449
4a83	DXC	Major pollen allergen Bet v 1-A	/	0.449
4du8	2P0	Mevalonate diphosphate decarboxylase	/	0.449
1a8r	GTP	GTP cyclohydrolase 1	3.5.4.16	0.448
1a9c	GTP	GTP cyclohydrolase 1	3.5.4.16	0.448
2ggs	NDP	dTDP-4-dehydrorhamnose reductase	/	0.448
4bfz	ZVZ	Pantothenate kinase	2.7.1.33	0.448
2a58	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.447
2yy2	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.447
4a81	DXC	Major pollen allergen Bet v 1-A	/	0.447
4iar	ERM	5-hydroxytryptamine receptor 1B	/	0.447
1c3x	8IG	Purine nucleoside phosphorylase	2.4.2.1	0.446
1sq5	ADP	Pantothenate kinase	2.7.1.33	0.446
1xe6	5FP	Plasmepsin-2	3.4.23.39	0.446
3n3z	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.446
3phi	NDP	Shikimate dehydrogenase (NADP(+))	/	0.446
4q0k	GA3	Phytohormone-binding protein	/	0.446
4uwm	FMN	3,6-diketocamphane 1,6 monooxygenase	1.14.13	0.446
2a94	AP0	L-lactate dehydrogenase	1.1.1.27	0.445
3vqs	JT1	Genome polyprotein	/	0.445
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.445
4a86	2AN	Major pollen allergen Bet v 1-A	/	0.445
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.445
5hsa	FAS	Alcohol oxidase 1	1.1.3.13	0.445
2bn4	FMN	NADPH--cytochrome P450 reductase	/	0.444
2cft	PLP	Pyridoxal phosphate phosphatase	/	0.444
2g8y	NAD	Hydroxycarboxylate dehydrogenase B	/	0.444
2o1s	TDP	1-deoxy-D-xylulose-5-phosphate synthase	2.2.1.7	0.444
2rqf	JH3	Hemolymph juvenile hormone binding protein	/	0.444
4bfs	ZVS	Pantothenate kinase	2.7.1.33	0.444
4prx	ADP	DNA gyrase subunit B	/	0.444
2he5	NDP	Aldo-keto reductase family 1 member C21	1.1.1	0.443
2iko	7IG	Renin	3.4.23.15	0.443
3fr5	I4A	Fatty acid-binding protein, adipocyte	/	0.443
4f4d	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.443
4i9h	1E4	L-lactate dehydrogenase A chain	1.1.1.27	0.443
4qec	NAP	ElxO	/	0.443
1w6h	TIT	Plasmepsin-2	3.4.23.39	0.442
2emu	SAH	Diphthine synthase	/	0.442
2ewm	NAD	(S)-1-Phenylethanol dehydrogenase	1.1.1.311	0.442
3sf6	FDA	Glutaryl-CoA dehydrogenase	/	0.442
4a8v	2AN	Major pollen allergen Bet v 1-J	/	0.442
1xe5	5FE	Plasmepsin-2	3.4.23.39	0.441
2bf4	FAD	NADPH--cytochrome P450 reductase	/	0.441
2ejz	SAH	Diphthine synthase	/	0.441
2fj1	CTC	Tetracycline repressor protein class D	/	0.441
2pb4	SAH	Diphthine synthase	/	0.441
2rbe	NDP	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.441
3af0	GDP	Pantothenate kinase	2.7.1.33	0.441
3fhx	PLP	Pyridoxal kinase	2.7.1.35	0.441
3h3t	16H	Collagen type IV alpha-3-binding protein	/	0.441
3q44	D50	M1 family aminopeptidase	3.4.11	0.441
4g7g	VFV	Lanosterol 14-alpha-demethylase	/	0.441
1t4c	COA	Formyl-CoA:oxalate CoA-transferase	/	0.440
1xs7	MMI	Beta-secretase 1	3.4.23.46	0.440
1yhj	R6C	Pyridoxal kinase	2.7.1.35	0.440
2dw4	FAD	Lysine-specific histone demethylase 1A	1	0.440
2gjl	FMN	Nitronate monooxygenase	1.13.12.16	0.440
2z1q	FAD	Acyl-CoA dehydrogenase	/	0.440
3d91	REM	Renin	3.4.23.15	0.440
3hl0	NAD	Maleylacetate reductase	/	0.440
3mpi	FAD	Glutaryl-CoA dehydrogenase	1.3.99.32	0.440
4eso	NAP	Putative oxidoreductase	/	0.440
4gl4	NAI	Alcohol dehydrogenase class-3	/	0.440
4zir	ANP	Energy-coupling factor transporter ATP-binding protein EcfA2	3.6.3	0.440
4zir	ANP	Energy-coupling factor transporter ATP-binding protein EcfA1	/	0.440
5b1y	NDP	3-oxoacyl-[acyl-carrier-protein] reductase	/	0.440
5dp2	NAP	CurF	/	0.440