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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wp5FADTrypanothione reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wp5FADTrypanothione reductase/1.000
2jk6FADTrypanothione reductase/0.601
4nevFADTrypanothione reductase/0.599
1tytFADTrypanothione reductase1.8.1.120.592
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.587
1gxfFADTrypanothione reductase1.8.1.120.581
2wbaFADTrypanothione reductase1.8.1.120.580
1bzlFADTrypanothione reductase1.8.1.120.577
4dnaFADProbable glutathione reductase/0.577
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.576
2hqmFADGlutathione reductase1.8.1.70.544
1febFADTrypanothione reductase1.8.1.120.540
1typFADTrypanothione reductase1.8.1.120.538
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.538
4la1FADThioredoxin glutathione reductase/0.533
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.530
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.527
1fecFADTrypanothione reductase1.8.1.120.525
2w0hFADTrypanothione reductase/0.525
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.524
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.521
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.518
2r9zFADGlutathione amide reductase/0.512
1grgFADGlutathione reductase, mitochondrial1.8.1.70.510
1feaFADTrypanothione reductase1.8.1.120.509
1grhFADGlutathione reductase, mitochondrial1.8.1.70.506
4j57FADThioredoxin reductase 21.8.1.90.505
1greFADGlutathione reductase, mitochondrial1.8.1.70.503
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.494
4j56FADThioredoxin reductase 21.8.1.90.486
2wowFADTrypanothione reductase/0.484
3ladFADDihydrolipoyl dehydrogenase/0.484
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.483
1graFADGlutathione reductase, mitochondrial1.8.1.70.479
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.475
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.472
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.466
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
4emwFADCoenzyme A disulfide reductase/0.455
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.453
1zx9FADMercuric reductase1.16.1.10.446
4jq9FADDihydrolipoyl dehydrogenase/0.444
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442