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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wotZZGTGF-beta receptor type-12.7.11.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wotZZGTGF-beta receptor type-12.7.11.301.000
5e8wSTUTGF-beta receptor type-12.7.11.300.599
2wouZZFTGF-beta receptor type-12.7.11.300.575
1vjy460TGF-beta receptor type-12.7.11.300.547
3gxlQIGTGF-beta receptor type-12.7.11.300.534
3mtfA3FActivin receptor type-12.7.11.300.534
3hmm855TGF-beta receptor type-12.7.11.300.529
1rw8580TGF-beta receptor type-12.7.11.300.526
2iw84SPCyclin-dependent kinase 22.7.11.220.515
1u4dDBQActivated CDC42 kinase 1/0.511
1bygSTUTyrosine-protein kinase CSK/0.504
1h1r6CPCyclin-dependent kinase 22.7.11.220.504
4dymIYZActivin receptor type-12.7.11.300.503
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.497
3uzp0CKCasein kinase I isoform delta2.7.11.10.495
4i22IREEpidermal growth factor receptor2.7.10.10.493
1h1s4SPCyclin-dependent kinase 22.7.11.220.491
4riyADPEpidermal growth factor receptor2.7.10.10.489
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.487
4erwSTUCyclin-dependent kinase 22.7.11.220.487
3s2pPMUCyclin-dependent kinase 22.7.11.220.486
4qmpDKISerine/threonine-protein kinase 242.7.11.10.486
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.483
4c02TAKActivin receptor type-12.7.11.300.483
4eor4SPCyclin-dependent kinase 22.7.11.220.483
2iw94SPCyclin-dependent kinase 22.7.11.220.481
3uyt0CKCasein kinase I isoform delta2.7.11.10.481
5e8xSTUTGF-beta receptor type-12.7.11.300.481
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.480
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.479
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.479
3oom507Activin receptor type-12.7.11.300.478
4gmy0X5Tyrosine-protein kinase JAK2/0.478
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.477
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.477
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.477
1py5PY1TGF-beta receptor type-12.7.11.300.475
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.475
1v0pPVBCell division control protein 2 homolog2.7.11.220.474
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.474
2yn8STUEphrin type-B receptor 42.7.10.10.473
3w33W19Epidermal growth factor receptor2.7.10.10.473
1u54ACPActivated CDC42 kinase 1/0.472
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.472
4bgg844Activin receptor type-12.7.11.300.472
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.471
3ddpRC8Cyclin-dependent kinase 22.7.11.220.471
1oiuN76Cyclin-dependent kinase 22.7.11.220.470
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.470
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.470
4fv9E71Mitogen-activated protein kinase 12.7.11.240.470
4gk3L87Ephrin type-A receptor 32.7.10.10.470
1oi9N20Cyclin-dependent kinase 22.7.11.220.469
3w32W32Epidermal growth factor receptor2.7.10.10.466
1jpaANPEphrin type-B receptor 22.7.10.10.465
4eon1ROCyclin-dependent kinase 22.7.11.220.465
4hnf16WCasein kinase I isoform delta2.7.11.10.465
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
1di8DTQCyclin-dependent kinase 22.7.11.220.464
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.464
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.464
4bcnT9NCyclin-dependent kinase 22.7.11.220.464
1oguST8Cyclin-dependent kinase 22.7.11.220.463
1g5sI17Cyclin-dependent kinase 22.7.11.220.462
3poz03PEpidermal growth factor receptor2.7.10.10.462
4gk2L66Ephrin type-A receptor 32.7.10.10.462
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.461
5e8ySTUTGF-beta receptor type-22.7.11.300.460
1ke7LS3Cyclin-dependent kinase 22.7.11.220.459
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.459
3ddqRRCCyclin-dependent kinase 22.7.11.220.459
4c61LMMTyrosine-protein kinase JAK2/0.459
2vwz7X6Ephrin type-B receptor 42.7.10.10.458
2vx17X8Ephrin type-B receptor 42.7.10.10.458
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.458
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.458
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.458
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.458
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.458
1unlRRCCyclin-dependent-like kinase 52.7.11.10.457
1vyw292Cyclin-dependent kinase 22.7.11.220.457
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.457
2qo9ANPEphrin type-A receptor 32.7.10.10.457
3ggfGVDSerine/threonine-protein kinase 26/0.457
3r1sX73Cyclin-dependent kinase 22.7.11.220.457
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.457
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.456
3vryB43Tyrosine-protein kinase HCK2.7.10.20.456
3zep1NXTyrosine-protein kinase JAK32.7.10.20.456
2w05FRTCyclin-dependent kinase 22.7.11.220.455
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.455
4bcpT3CCyclin-dependent kinase 22.7.11.220.455
1h0w207Cyclin-dependent kinase 22.7.11.220.454
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
2p33J07Mitogen-activated protein kinase 102.7.11.240.454
3ocgOCGMitogen-activated protein kinase 14/0.454
3qu0X40Cyclin-dependent kinase 22.7.11.220.454
3qzhX69Cyclin-dependent kinase 22.7.11.220.454
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.454
5e92ANPTGF-beta receptor type-22.7.11.300.454
1gih1PUCyclin-dependent kinase 22.7.11.220.452
2vwx7X4Ephrin type-B receptor 42.7.10.10.452
3pj8404Cyclin-dependent kinase 22.7.11.220.452
3vs3VSETyrosine-protein kinase HCK2.7.10.20.452
4hvh19RTyrosine-protein kinase JAK32.7.10.20.452
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.451
3rk909ZCyclin-dependent kinase 22.7.11.220.451
1ckpPVBCyclin-dependent kinase 22.7.11.220.450
1e9hINRCyclin-dependent kinase 22.7.11.220.450
1oiyN41Cyclin-dependent kinase 22.7.11.220.450
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
2in6839Wee1-like protein kinase2.7.10.20.450
3qqkX02Cyclin-dependent kinase 22.7.11.220.450
4hge15VTyrosine-protein kinase JAK2/0.450
2pwlACPFibroblast growth factor receptor 2/0.449
3rpr25ZCyclin-dependent kinase 22.7.11.220.449
2xa4AZ5Tyrosine-protein kinase JAK2/0.448
4jq8KJ8Epidermal growth factor receptor2.7.10.10.448
4kba1QMCasein kinase I isoform delta2.7.11.10.448
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.447
2o0uC0MMitogen-activated protein kinase 102.7.11.240.447
2r64740Cyclin-dependent kinase 22.7.11.220.447
3vt7VDXVitamin D3 receptor/0.447
4kb81QNCasein kinase I isoform delta2.7.11.10.447
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.447
4qms1N1Serine/threonine-protein kinase 242.7.11.10.447
1ke6LS2Cyclin-dependent kinase 22.7.11.220.446
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2c4g514Cyclin-dependent kinase 22.7.11.220.446
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.446
3rm719ZCyclin-dependent kinase 22.7.11.220.446
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
2vu3LZECyclin-dependent kinase 22.7.11.220.445
2vwy7X5Ephrin type-B receptor 42.7.10.10.445
2w06FRVCyclin-dependent kinase 22.7.11.220.445
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.445
3r28XA0Cyclin-dependent kinase 22.7.11.220.445
3sqq99ZCyclin-dependent kinase 22.7.11.220.445
4e4m0NHTyrosine-protein kinase JAK2/0.445
1gij2PUCyclin-dependent kinase 22.7.11.220.444
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.444
2x1nX1NCyclin-dependent kinase 22.7.11.220.444
3qwkX62Cyclin-dependent kinase 22.7.11.220.444
3r73X87Cyclin-dependent kinase 22.7.11.220.444
3r9hZ67Cyclin-dependent kinase 22.7.11.220.444
3ttjJBIMitogen-activated protein kinase 102.7.11.240.444
4bcoT6QCyclin-dependent kinase 22.7.11.220.444
1h1q2A6Cyclin-dependent kinase 22.7.11.220.443
1xjdSTUProtein kinase C theta type2.7.11.130.443
1xkkFMMEpidermal growth factor receptor2.7.10.10.443
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2pmlANPUncharacterized protein/0.443
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.443
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.443
3r9dX6BCyclin-dependent kinase 22.7.11.220.443
3zh8C58Protein kinase C iota type2.7.11.130.443
4uymVOR14-alpha sterol demethylase Cyp51B/0.443
2c475IDCasein kinase I isoform gamma-2/0.442
2c6o4SPCyclin-dependent kinase 22.7.11.220.442
2fvdLIACyclin-dependent kinase 22.7.11.220.442
2vx07X7Ephrin type-B receptor 42.7.10.10.442
3k5uPFQAurora kinase A2.7.11.10.442
4fx360KCyclin-dependent kinase 22.7.11.220.442
4g2fC07Ephrin type-A receptor 32.7.10.10.442
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.442
1oitHDTCyclin-dependent kinase 22.7.11.220.441
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.441
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.441
3rpv26ZCyclin-dependent kinase 22.7.11.220.441
4k6z1Q3Tyrosine-protein kinase JAK1/0.441
3lfnA27Cyclin-dependent kinase 22.7.11.220.440
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4wkqIREEpidermal growth factor receptor2.7.10.10.440