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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wogZZDKinesin-like protein KIF11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wogZZDKinesin-like protein KIF11/1.000
3kenZZDKinesin-like protein KIF11/0.630
4bbgV02Kinesin-like protein KIF11/0.618
2x2rX2OKinesin-like protein KIF11/0.614
2x7eX7EKinesin-like protein KIF11/0.599
2q2zMKKKinesin-like protein KIF11/0.587
2x7dEGBKinesin-like protein KIF11/0.583
2xae2XAKinesin-like protein KIF11/0.581
2g1qN9HKinesin-like protein KIF11/0.578
2iehMOYKinesin-like protein KIF11/0.578
1q0bNATKinesin-like protein KIF11/0.572
4a51DQ8Kinesin-like protein KIF11/0.559
2fme3QCKinesin-like protein KIF11/0.554
2gm12AZKinesin-like protein KIF11/0.549
3k3bL31Kinesin-like protein KIF11/0.549
3k5eK5EKinesin-like protein KIF11/0.546
1x88NATKinesin-like protein KIF11/0.544
2x7cKZ9Kinesin-like protein KIF11/0.528
4a5yG7XKinesin-like protein KIF11/0.526
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.494
4as76LXKinesin-like protein KIF11/0.494
4c9pCAMCytochrome P450/0.491
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.489
1xdiFADNAD(P)H dehydrogenase (quinone)/0.485
2bxe1FLSerum albumin/0.479
4hyp1A1DNA gyrase subunit B/0.479
1fvt106Cyclin-dependent kinase 22.7.11.220.476
4ej4EJ4Delta-type opioid receptor/0.476
4jx1CAMCamphor 5-monooxygenase1.14.15.10.475
1o76CAMCamphor 5-monooxygenase1.14.15.10.473
2a1mCAMCamphor 5-monooxygenase1.14.15.10.472
4yswNAIXanthine dehydrogenase/oxidase/0.471
4anqVGHALK tyrosine kinase receptor2.7.10.10.470
2iw84SPCyclin-dependent kinase 22.7.11.220.469
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.469
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.469
4lg5A1OAbscisic acid receptor PYL2/0.468
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.467
3nmpPYVAbscisic acid receptor PYL2/0.467
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.465
3lu7IPXSerum albumin/0.464
4v12POGMaoC like domain protein/0.464
1me8RVPInosine-5'-monophosphate dehydrogenase/0.463
2vwqNAPGlucose 1-dehydrogenase/0.463
4g95OAGDihydrofolate reductase1.5.1.30.463
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.462
2qboCAMCamphor 5-monooxygenase1.14.15.10.462
5e8ySTUTGF-beta receptor type-22.7.11.300.462
1u3cFADCryptochrome-1/0.461
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.461
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.461
1rx7FOLDihydrofolate reductase1.5.1.30.460
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.460
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.460
3mdmFJZCholesterol 24-hydroxylase/0.460
4ansVGHALK tyrosine kinase receptor2.7.10.10.460
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
4jx1CAHCamphor 5-monooxygenase1.14.15.10.460
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.459
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.459
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.459
1dz8CAMCamphor 5-monooxygenase1.14.15.10.458
2yfxVGHALK tyrosine kinase receptor2.7.10.10.458
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.458
4h9814QUncharacterized protein/0.458
3mdvCL6Cholesterol 24-hydroxylase/0.457
3qlrNDPDihydrofolate reductase1.5.1.30.457
3rk708ZCyclin-dependent kinase 22.7.11.220.457
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.457
4n6hEJ4Delta-type opioid receptor/0.457
1dz6CAMCamphor 5-monooxygenase1.14.15.10.456
1phePIYCamphor 5-monooxygenase1.14.15.10.456
1t85CAMCamphor 5-monooxygenase1.14.15.10.456
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.456
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.456
4l4bCAMCamphor 5-monooxygenase1.14.15.10.456
1s6qTPBGag-Pol polyprotein2.7.7.490.455
1u3dFADCryptochrome-1/0.455
2qbnCAMCamphor 5-monooxygenase1.14.15.10.455
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.455
4fkpLS5Cyclin-dependent kinase 22.7.11.220.455
4nmbFADBifunctional protein PutA/0.455
4z34ON7Lysophosphatidic acid receptor 1/0.455
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.454
3rjc06ZCyclin-dependent kinase 22.7.11.220.454
4an35Y0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.454
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.454
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.453
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.453
2opqHBQGag-Pol polyprotein2.7.7.490.453
2qblCAMCamphor 5-monooxygenase1.14.15.10.453
3qx4X4BCyclin-dependent kinase 22.7.11.220.453
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.453
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.453
1v0pPVBCell division control protein 2 homolog2.7.11.220.452
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2zawCAMCamphor 5-monooxygenase1.14.15.10.452
3rm618ZCyclin-dependent kinase 22.7.11.220.452
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.452
3zewSTUEphrin type-B receptor 42.7.10.10.452
4c9oCAMCytochrome P450/0.452
4h3ySAHtRNA (guanine-N(1)-)-methyltransferase/0.452
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.452
5aacVGHALK tyrosine kinase receptor2.7.10.10.452
2a87FADThioredoxin reductase1.8.1.90.451
2oz6CMPCyclic AMP receptor-like protein/0.451
3qrtX14Cyclin-dependent kinase 22.7.11.220.451
3rk909ZCyclin-dependent kinase 22.7.11.220.451
4g3rCAMCamphor 5-monooxygenase1.14.15.10.451
4yryFADGlutamate synthase, beta subunit/0.451
1df7MTXDihydrofolate reductase1.5.1.30.450
1iqrFADDeoxyribodipyrimidine photo-lyase4.1.99.30.450
1npa3NHGag-Pol polyprotein3.4.23.160.450
1npwLGZGag-Pol polyprotein3.4.23.160.450
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.450
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.450
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.450
3cppCAMCamphor 5-monooxygenase1.14.15.10.450
3h0sB38Acetyl-CoA carboxylase/0.450
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.450
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.450
4fv9E71Mitogen-activated protein kinase 12.7.11.240.450
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.450
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4z35ON9Lysophosphatidic acid receptor 1/0.450
1mtrPI6Gag-Pol polyprotein3.4.23.160.449
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.449
3a1l2CCCytochrome P450/0.449
3cgdCOACoenzyme A disulfide reductase/0.449
3nefPYVAbscisic acid receptor PYL1/0.449
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
3rni21ZCyclin-dependent kinase 22.7.11.220.449
3roc29AMitogen-activated protein kinase 14/0.449
4eor4SPCyclin-dependent kinase 22.7.11.220.449
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
4ho2THMGlucose-1-phosphate thymidylyltransferase/0.449
4jlt8PRCytochrome P450 2B41.14.14.10.449
4rbs0RVMetallo-beta-lactamase type 2/0.449
1h1s4SPCyclin-dependent kinase 22.7.11.220.448
2c3cNAP2-oxopropyl-CoM reductase, carboxylating1.8.1.50.448
2m56CAMCamphor 5-monooxygenase1.14.15.10.448
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.448
2pym1UNGag-Pol polyprotein3.4.23.160.448
2wipP49Cyclin-dependent kinase 22.7.11.220.448
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.448
2yee2ECHeat shock protein HSP 90-alpha/0.448
3gi3B10Mitogen-activated protein kinase 14/0.448
3ladFADDihydrolipoyl dehydrogenase/0.448
4a7b3W4Collagenase 33.4.240.448
4asf62UATP-dependent molecular chaperone HSP82/0.448
4c4jX21Dual specificity protein kinase TTK2.7.12.10.448
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.448
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.448
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.448
4l4cCAMCamphor 5-monooxygenase1.14.15.10.448
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4xdmGDMHeat shock cognate 90 kDa protein/0.448
1k6cMK1Gag-Pol polyprotein3.4.23.160.447
1tj0FADBifunctional protein PutA1.5.5.20.447
2a1nCAMCamphor 5-monooxygenase1.14.15.10.447
2b5vNAPGlucose 1-dehydrogenase/0.447
2q631UNGag-Pol polyprotein3.4.23.160.447
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.447
2wotZZGTGF-beta receptor type-12.7.11.300.447
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.447
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.447
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.447
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3p7bP7BMitogen-activated protein kinase 14/0.447
3ujlA8SAbscisic acid receptor PYL2/0.447
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.447
4fk1FADPutative thioredoxin reductase/0.447
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.447
4kkyCAMCamphor 5-monooxygenase1.14.15.10.447
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1dajMOTDihydrofolate reductase1.5.1.30.446
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.446
3fwgCAMCamphor 5-monooxygenase1.14.15.10.446
3l63CAMCamphor 5-monooxygenase1.14.15.10.446
3meeT27Gag-Pol polyprotein2.7.7.490.446
3p3zP3ZPutative cytochrome P450/0.446
3p5kP5KMitogen-activated protein kinase 14/0.446
3rpr25ZCyclin-dependent kinase 22.7.11.220.446
3s1h56ZCyclin-dependent kinase 22.7.11.220.446
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.446
4cdmFADDeoxyribodipyrimidine photolyase/0.446
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.446
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.446
1drbMTXDihydrofolate reductase1.5.1.30.445
1rc4DDFDihydrofolate reductase1.5.1.30.445
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1t87CAMCamphor 5-monooxygenase1.14.15.10.445
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.445
2zaxCAMCamphor 5-monooxygenase1.14.15.10.445
3fwiCAMCamphor 5-monooxygenase1.14.15.10.445
3iqeF42F420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.445
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3juhANPCasein kinase II subunit alpha2.7.11.10.445
3mg3ECHOrange carotenoid-binding protein/0.445
3oafOAGDihydrofolate reductase1.5.1.30.445
3os33OSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
3wrmCAMCamphor 5-monooxygenase1.14.15.10.445
4egnTWOCytochrome P450/0.445
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.445
4nm9FADBifunctional protein PutA/0.445
4o0wADNAurora kinase A2.7.11.10.445
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.445
1dssNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.444
1m9k7NINitric oxide synthase, endothelial1.14.13.390.444
1merDMQGag-Pol polyprotein3.4.23.160.444
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.444
2y9qANPMitogen-activated protein kinase 12.7.11.240.444
3ddqRRCCyclin-dependent kinase 22.7.11.220.444
3dk1G05Gag-Pol polyprotein3.4.23.160.444
3eej53RUncharacterized protein/0.444
1aq1STUCyclin-dependent kinase 22.7.11.220.443
1d7yFADFerredoxin reductase/0.443
1dz4CAMCamphor 5-monooxygenase1.14.15.10.443
1oc1ASVIsopenicillin N synthase1.21.3.10.443
1tezHDFDeoxyribodipyrimidine photo-lyase4.1.99.30.443
1uyuCAMCamphor 5-monooxygenase1.14.15.10.443
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.443
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.443
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.443
3d7kD7KBenzaldehyde lyase/0.443
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3eigMTXDihydrofolate reductase1.5.1.30.443
3ii43IIDihydrolipoyl dehydrogenase1.8.1.40.443
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.443
3rkb12ZCyclin-dependent kinase 22.7.11.220.443
4asg814ATP-dependent molecular chaperone HSP82/0.443
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4fgg0U5Dihydrofolate reductase1.5.1.30.443
4jlk1NODeoxycytidine kinase2.7.1.740.443
4l4dCAMCamphor 5-monooxygenase1.14.15.10.443
4oicA8SBet v I allergen-like/0.443
1bl6SB6Mitogen-activated protein kinase 14/0.442
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.442
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
1oi9N20Cyclin-dependent kinase 22.7.11.220.442
1suoCPZCytochrome P450 2B41.14.14.10.442
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.442
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.442
2gpuOHTEstrogen-related receptor gamma/0.442
2q7vFADThioredoxin reductase/0.442
2vn0TDZCytochrome P450 2C8/0.442
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.442
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.442
2ykcYKCHeat shock protein HSP 90-alpha/0.442
2ykiYKIHeat shock protein HSP 90-alpha/0.442
3fwjCAMCamphor 5-monooxygenase1.14.15.10.442
3kb0A8SAbscisic acid receptor PYL2/0.442
3lu8IQXSerum albumin/0.442
3qxoX65Cyclin-dependent kinase 22.7.11.220.442
3qyw6PBMitogen-activated protein kinase 12.7.11.240.442
4baeRWXDNA gyrase subunit B/0.442
4dlj6RGMitogen-activated protein kinase 14/0.442
4eok4SPCyclin-dependent kinase 22.7.11.220.442
4erwSTUCyclin-dependent kinase 22.7.11.220.442
4fmqANPMitogen-activated protein kinase 12.7.11.240.442
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.442
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.442
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.442
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.442
1adfTADAlcohol dehydrogenase E chain1.1.1.10.441
1fl2FADAlkyl hydroperoxide reductase subunit F1.8.10.441
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.441
1vyzN5BCyclin-dependent kinase 22.7.11.220.441
2cduFADNADH oxidase/0.441
2feuCAMCamphor 5-monooxygenase1.14.15.10.441
3a8wATPProtein kinase C iota type2.7.11.130.441
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.441
3b895GP16S rRNA methylase/0.441
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.441
3gwuSRENa(+):neurotransmitter symporter (Snf family)/0.441
3lltANPProtein serine/threonine kinase-1/0.441
3pb3SAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.441
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.441
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4lch1WNUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.441
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
5e8wSTUTGF-beta receptor type-12.7.11.300.441
1jutLYDThymidylate synthase/0.440
1ke9LS5Cyclin-dependent kinase 22.7.11.220.440
2hog710Serine/threonine-protein kinase Chk12.7.11.10.440
2itpAEEEpidermal growth factor receptor2.7.10.10.440
2j5xGSPADP-ribosylation factor 6/0.440
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.440
2vg5NNCGag-Pol polyprotein2.7.7.490.440
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.440
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.440
3kdiA8SAbscisic acid receptor PYL2/0.440
3lfnA27Cyclin-dependent kinase 22.7.11.220.440
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.440
3ogqAB1Pol polyprotein/0.440
3opdHIEHeat shock protein 83/0.440
3pwrROCGag-Pol polyprotein3.4.23.160.440
3r9hZ67Cyclin-dependent kinase 22.7.11.220.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.440
4ei7GDPPlasmid replication protein RepX/0.440
4l4eCAMCamphor 5-monooxygenase1.14.15.10.440