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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2whdFADThioredoxin reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2whdFADThioredoxin reductase/1.000
4up3FADThioredoxin reductase/0.512
3itjFADThioredoxin reductase 11.8.1.90.506
4cbqFADThioredoxin reductase/0.506
2q7vFADThioredoxin reductase/0.505
4jnqFDAThioredoxin reductase/0.499
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.479
4a5lFADThioredoxin reductase/0.475
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.472
3r9uFADThioredoxin reductase/0.471
2a7r5GPGMP reductase 2/0.466
3ctyFADProbable thioredoxin reductase/0.464
3ishFADThioredoxin reductase1.8.1.90.464
3gw9VNILanosterol 14-alpha-demethylase/0.459
4a65FADThioredoxin reductase/0.459
2xlrFADPutative flavin-containing monooxygenase/0.456
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
5dp2NAPCurF/0.455
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.452
4dh60KNBeta-secretase 13.4.23.460.451
3lpjZ75Beta-secretase 13.4.23.460.450
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
3b70NAPEnoyl reductase LovC10.446
4fk1FADPutative thioredoxin reductase/0.446
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.446
5a3bAPRSIR2 family protein/0.445
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1w6hTITPlasmepsin-23.4.23.390.444
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.443
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
2xpwOTCTetracycline repressor protein class D/0.441
2ignFADPyranose 2-oxidase/0.440
3ggoNAIPrephenate dehydrogenase/0.440