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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wedPP6Penicillopepsin-13.4.23.20

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wedPP6Penicillopepsin-13.4.23.201.000
2wecPP5Penicillopepsin-13.4.23.200.781
1bxqPP8Penicillopepsin-13.4.23.200.663
1bxoPP7Penicillopepsin-13.4.23.200.656
1ppm0P1Penicillopepsin-13.4.23.200.655
1ppkIVVPenicillopepsin-13.4.23.200.602
2webPP4Penicillopepsin-13.4.23.200.598
1ppl1Z7Penicillopepsin-13.4.23.200.580
1e82M90Endothiapepsin3.4.23.220.506
1gvt2ZSEndothiapepsin3.4.23.220.506
3psyRB9Endothiapepsin3.4.23.220.506
1gvw0EMEndothiapepsin3.4.23.220.504
1e81M91Endothiapepsin3.4.23.220.502
1od10QSEndothiapepsin3.4.23.220.502
2jjj0QSEndothiapepsin3.4.23.220.499
2jji0QSEndothiapepsin3.4.23.220.498
3prsRITEndothiapepsin3.4.23.220.498
3pm4F5NEndothiapepsin3.4.23.220.497
3pwwROCEndothiapepsin3.4.23.220.494
4y380A9Endothiapepsin3.4.23.220.491
4yd7F5NEndothiapepsin3.4.23.220.481
3t7x4SHEndothiapepsin3.4.23.220.478
3pgiF41Endothiapepsin3.4.23.220.472
1e800GQEndothiapepsin3.4.23.220.469
3tneRITCandidapepsin-13.4.23.240.462
3lpjZ75Beta-secretase 13.4.23.460.456
1gvv0GMEndothiapepsin3.4.23.220.455
1psa0ZLPepsin A3.4.23.10.453
2v00V15Endothiapepsin3.4.23.220.448
4y3zF41Endothiapepsin3.4.23.220.447
1zapA70Candidapepsin-23.4.23.240.443
4y3jHICEndothiapepsin3.4.23.220.440