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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wdzNADGalactitol dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wdzNADGalactitol dehydrogenase/1.000
2wsbNADGalactitol dehydrogenase/0.610
5jlaNADPutative short-chain dehydrogenase/reductase/0.573
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.556
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.548
3lqfNADGalactitol dehydrogenase/0.545
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.539
1iy8NADLevodione reductase/0.535
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.532
1x7gNAPPutative ketoacyl reductase1.3.10.532
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.532
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.532
1w4zNAPPutative ketoacyl reductase1.3.10.529
1pr9NAPL-xylulose reductase1.1.1.100.524
1wntNAPL-xylulose reductase1.1.1.100.523
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.521
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.519
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.517
1geeNADGlucose 1-dehydrogenase1.1.1.470.515
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.515
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.515
3toxNAPPutative oxidoreductase/0.514
4gh5NADShort-chain dehydrogenase/reductase SDR/0.513
4hwkNAPSepiapterin reductase1.1.1.1530.513
3w8eNAD3-hydroxybutyrate dehydrogenase/0.512
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.511
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.507
4fn4NADShort chain dehydrogenase/0.507
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.506
1x7hNDPPutative ketoacyl reductase1.3.10.506
1rwbNADGlucose 1-dehydrogenase1.1.1.470.505
3vdqNAD3-hydroxybutyrate dehydrogenase/0.505
1gcoNADGlucose 1-dehydrogenase1.1.1.470.504
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.504
3s55NADPutative short-chain dehydrogenase/reductase/0.504
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.503
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.503
3p19NDPPutative blue fluorescent protein/0.502
4dc1NDPPutative ketoacyl reductase1.3.10.502
4j7xNAPSepiapterin reductase1.1.1.1530.502
1n5dNDPCarbonyl reductase [NADPH] 1/0.500
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.500
4j7uNAPSepiapterin reductase1.1.1.1530.498
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.498
1g6kNADGlucose 1-dehydrogenase1.1.1.470.495
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.493
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.492
3uxyNADShort-chain dehydrogenase/reductase SDR/0.492
4yaiNAIC alpha-dehydrogenase/0.492
3d3wNAPL-xylulose reductase1.1.1.100.491
4yagNAIC alpha-dehydrogenase/0.491
5idwNAPShort-chain dehydrogenase/reductase SDR/0.491
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.490
1snyNAPLD36273p/0.489
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.489
1ipeNDPTropinone reductase 21.1.1.2360.488
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.488
3sjuNDPKeto reductase/0.488
4nbwNADShort-chain dehydrogenase/reductase SDR/0.488
1ae1NAPTropinone reductase 1/0.487
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.486
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.486
3sx2NADUncharacterized protein/0.486
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.486
3qrwNDPPutative ketoacyl reductase1.3.10.485
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.485
1mg5NAIAlcohol dehydrogenase1.1.1.10.484
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.484
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.483
2dteNAIGlucose 1-dehydrogenase related protein/0.483
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.483
5lc1NADL-threonine 3-dehydrogenase/0.483
2bd0NAPSepiapterin reductase/0.482
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.481
3a1nNADNDP-sugar epimerase/0.480
3gy0NAPNAD(P)-dependent oxidoreductase/0.480
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.479
3w8dNAD3-hydroxybutyrate dehydrogenase/0.478
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.478
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.477
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.476
3ai2NDPNADPH-sorbose reductase/0.476
3w8fNAD3-hydroxybutyrate dehydrogenase/0.476
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.473
3rj9NADAlcohol dehydrogenase1.1.1.10.472
1oaaNAPSepiapterin reductase1.1.1.1530.471
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.471
3a4vNADNDP-sugar epimerase/0.469
3ak4NADNADH-dependent quinuclidinone reductase/0.469
1b15NAEAlcohol dehydrogenase1.1.1.10.468
1xg5NAPDehydrogenase/reductase SDR family member 11/0.468
2yutNAPPutative short-chain oxidoreductase/0.468
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.467
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.467
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.467
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.466
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.465
1b16NAQAlcohol dehydrogenase1.1.1.10.464
5jydNADShort chain dehydrogenase/0.464
2p5uNADUDP-glucose 4-epimerase/0.462
2x86NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.462
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.461
3ggoNAIPrephenate dehydrogenase/0.459
3rj5NADAlcohol dehydrogenase1.1.1.10.459
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.459
2yy7NADL-threonine dehydrogenase/0.458
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.457
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
3f1kNAPUncharacterized oxidoreductase YciK10.456
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.456
3wdsNADNADH-dependent quinuclidinone reductase/0.455
4bmvNAPShort-chain dehydrogenase/0.455
1zemNADXylitol dehydrogenase/0.453
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.453
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.452
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.451
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.451
5ig2NADShort-chain dehydrogenase/reductase SDR/0.449
5jy1NADPutative short-chain dehydrogenase/reductase/0.449
2jahNDPClavaldehyde dehydrogenase/0.448
3tscNADUncharacterized protein/0.448
1xkqNDPUncharacterized protein/0.446
3u4cNDPNADPH-dependent reductase BacG/0.446
1kvrNADUDP-glucose 4-epimerase5.1.3.20.445
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.445
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.444
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.442
4b79NADProbable short-chain dehydrogenase/0.442