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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.31.000
4ele31IDihydrofolate reductase/0.497
4elg52JDihydrofolate reductase/0.490
4dfrMTXDihydrofolate reductase1.5.1.30.489
1diuBDMDihydrofolate reductase1.5.1.30.488
4elb34RDihydrofolate reductase/0.487
3fl8RARDihydrofolate reductase/0.485
3och2MXDihydrofolate reductase1.5.1.30.483
1dhjMTXDihydrofolate reductase1.5.1.30.481
3drcMTXDihydrofolate reductase1.5.1.30.473
1jolFFODihydrofolate reductase1.5.1.30.470
1ddrMTXDihydrofolate reductase1.5.1.30.467
2drcMTXDihydrofolate reductase1.5.1.30.464
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.462
1ddsMTXDihydrofolate reductase1.5.1.30.459
1draMTXDihydrofolate reductase1.5.1.30.457
3t2zFADSulfide-quinone reductase/0.452
4elb34SDihydrofolate reductase/0.451
4cd2FOLDihydrofolate reductase1.5.1.30.450
1jioDEB6-deoxyerythronolide B hydroxylase/0.449
1disBDMDihydrofolate reductase1.5.1.30.447
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1pkfEPDEpothilone C/D epoxidase1.140.444
1tdrMTXDihydrofolate reductase1.5.1.30.440
4b7dQLECytochrome P450 monooxygenase PikC/0.440