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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2w5aADPSerine/threonine-protein kinase Nek22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2w5aADPSerine/threonine-protein kinase Nek22.7.11.11.000
3d5wADPSerine/threonine-protein kinase PLK/0.484
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.478
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.478
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.465
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.460
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.457
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.457
1x8b824Wee1-like protein kinase2.7.10.20.453
3cr0809Wee1-like protein kinase2.7.10.20.447