sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2w3v | TOP | Dihydrofolate reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2w3v | TOP | Dihydrofolate reductase | / | 1.000 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.603 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.602 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.597 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.595 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.594 | |
| 3eek | 53S | Uncharacterized protein | / | 0.593 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.593 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.592 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.588 | |
| 3eel | 53T | Uncharacterized protein | / | 0.587 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.582 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.582 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.581 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.579 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.578 | |
| 3eej | 53R | Uncharacterized protein | / | 0.577 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.566 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.565 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.563 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 3cse | N22 | Uncharacterized protein | / | 0.562 | |
| 3eem | 53V | Uncharacterized protein | / | 0.559 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.557 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.556 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.556 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.555 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.555 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.555 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.552 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.551 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.551 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 3qly | 55V | Uncharacterized protein | / | 0.548 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.547 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.542 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.537 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.536 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.533 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.530 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.530 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.529 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.529 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.528 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.527 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.521 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.517 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.514 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.514 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.509 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.509 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.509 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.500 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.499 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.499 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.499 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.494 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.493 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.489 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.487 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.485 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.485 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.484 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.484 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.482 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.482 | |
| 1ysx | 4EB | Serum albumin | / | 0.481 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.480 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.478 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.473 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.473 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.473 | |
| 1kyo | SMA | Cytochrome b | / | 0.472 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.471 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.468 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.468 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.467 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.467 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.467 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.466 | |
| 3dho | B2M | Streptogramin A acetyltransferase | 2.3.1 | 0.466 | |
| 3lu8 | IQX | Serum albumin | / | 0.466 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.466 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1ezv | SMA | Cytochrome b | / | 0.464 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4zas | TYD | CalS13 | / | 0.464 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.463 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.463 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.462 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.462 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.462 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.461 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.461 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.461 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2vf0 | F89 | Thymidylate synthase | / | 0.460 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.460 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.460 | |
| 4flp | JQ1 | Bromodomain testis-specific protein | / | 0.460 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1nde | MON | Estrogen receptor beta | / | 0.459 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 2hnz | PC0 | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.458 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.458 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.458 | |
| 1kb9 | SMA | Cytochrome b | / | 0.457 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.457 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.457 | |
| 5dq8 | FLF | Transcriptional enhancer factor TEF-4 | / | 0.457 | |
| 1kij | NOV | DNA gyrase subunit B | / | 0.456 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 3cx5 | SMA | Cytochrome b | / | 0.456 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.456 | |
| 4j0s | 1H3 | Bromodomain-containing protein 4 | / | 0.456 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.456 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.455 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.455 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.455 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.454 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.454 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.454 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.454 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.454 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.453 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.453 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 3tdl | 11D | Serum albumin | / | 0.453 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.453 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.453 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.452 | |
| 1r9o | FLP | Cytochrome P450 2C9 | / | 0.452 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.452 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.452 | |
| 4a9o | A9O | Bromodomain-containing protein 2 | / | 0.452 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.451 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.451 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.451 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3s1c | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.451 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.451 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.451 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.450 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.450 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.450 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.450 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.450 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.450 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.450 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.449 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.449 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3dol | GWI | Pol protein | / | 0.449 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.449 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.449 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.449 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.449 | |
| 1nq0 | 4HY | Thyroid hormone receptor beta | / | 0.448 | |
| 1osv | CHC | Bile acid receptor | / | 0.448 | |
| 2jfa | RAL | Estrogen receptor | / | 0.448 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.448 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.448 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.448 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.447 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.447 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2iog | IOG | Estrogen receptor | / | 0.447 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.447 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.447 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.447 | |
| 3m8p | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.447 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.447 | |
| 4l8u | 9AZ | Serum albumin | / | 0.447 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.447 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.446 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.446 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.446 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.446 | |
| 2zym | ACX | Periplasmic binding protein | / | 0.446 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.446 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.446 | |
| 3p9t | TCL | Repressor | / | 0.446 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.446 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.446 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.446 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.446 | |
| 1fr8 | GDU | Beta-1,4-galactosyltransferase 1 | / | 0.445 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.445 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 2ard | FDA | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.445 | |
| 2z4b | DC8 | Estrogen receptor beta | / | 0.445 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 3cxh | SMA | Cytochrome b | / | 0.445 | |
| 4akn | S5B | Bromodomain-containing protein 2 | / | 0.445 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.445 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.445 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4lux | QJ8 | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.444 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.444 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.444 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.444 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.443 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.443 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.443 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.443 | |
| 4ig3 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.443 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.443 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.443 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1mc5 | AHE | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1tkz | H16 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.442 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.442 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2qgt | EED | Estrogen receptor | / | 0.442 | |
| 3a0i | AJI | Glucokinase | 2.7.1.2 | 0.442 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.442 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.442 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.442 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.442 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.441 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.441 | |
| 1rev | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.441 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 1ywr | LI9 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2ghm | LIC | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.441 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.441 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.441 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.441 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.441 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.441 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.441 | |
| 4egn | TWO | Cytochrome P450 | / | 0.441 | |
| 4i2q | 1BT | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 4j4v | SVR | Nucleocapsid protein | / | 0.441 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 2ibz | SMA | Cytochrome b | / | 0.440 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.440 | |
| 2ybo | SAH | Methyltransferase | / | 0.440 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.440 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.440 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.440 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3qfv | NM7 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.440 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.440 | |
| 4a9n | A9N | Bromodomain-containing protein 2 | / | 0.440 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.440 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.440 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.440 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.440 |