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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vwiANPSerine/threonine-protein kinase OSR12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2vwiANPSerine/threonine-protein kinase OSR12.7.11.11.000
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.537
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.516
4riyADPEpidermal growth factor receptor2.7.10.10.501
4k33ACPFibroblast growth factor receptor 32.7.10.10.498
4bbe3O4Tyrosine-protein kinase JAK2/0.495
1qmzATPCyclin-dependent kinase 22.7.11.220.492
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.492
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.492
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.491
4iirANPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.487
3c4zADPRhodopsin kinase/0.483
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.482
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.482
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.482
1h0w207Cyclin-dependent kinase 22.7.11.220.481
4ix5ANPUncharacterized protein/0.481
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.480
1u54ACPActivated CDC42 kinase 1/0.479
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.478
3repATPIntegrin-linked protein kinase2.7.11.10.478
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.478
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.477
2pmlANPUncharacterized protein/0.477
5cnnANPEpidermal growth factor receptor2.7.10.10.477
4z69DIFSerum albumin/0.475
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.474
3c4wATPRhodopsin kinase/0.474
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.474
1ir3ANPInsulin receptor2.7.10.10.472
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.472
2pzpACPFibroblast growth factor receptor 2/0.472
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.472
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.472
4l8u9AZSerum albumin/0.471
4l9i8PRRhodopsin kinase/0.471
4qmlANPSerine/threonine-protein kinase 242.7.11.10.471
3poz03PEpidermal growth factor receptor2.7.10.10.470
3qc9ADPRhodopsin kinase/0.470
3t8oATPRhodopsin kinase/0.469
4jrnANPRhoptry kinase family protein/0.469
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.469
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.468
3wowANPCasein kinase II subunit alpha2.7.11.10.468
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.466
4ii5ADPCyclin-dependent kinase 22.7.11.220.466
4j99ACPFibroblast growth factor receptor 2/0.466
2henADPEphrin type-B receptor 22.7.10.10.465
1csnATPCasein kinase I homolog 12.7.11.10.464
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.464
2dcnADP2-keto-3-deoxy-gluconate kinase/0.464
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.463
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.463
2izrBRKCasein kinase I isoform gamma-32.7.11.10.463
3plsANPMacrophage-stimulating protein receptor2.7.10.10.463
4ysjADPCalmodulin-like domain protein kinase/0.462
4zseANPEpidermal growth factor receptor2.7.10.10.462
1cm8ANPMitogen-activated protein kinase 12/0.461
1hckATPCyclin-dependent kinase 22.7.11.220.461
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.461
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.461
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.461
1jstATPCyclin-dependent kinase 22.7.11.220.460
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.460
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.460
4o1pANPRibonuclease L/0.460
1b38ATPCyclin-dependent kinase 22.7.11.220.459
2c4g514Cyclin-dependent kinase 22.7.11.220.459
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.458
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.458
4s33ANPMitogen-activated protein kinase 12.7.11.240.458
1b39ATPCyclin-dependent kinase 22.7.11.220.457
2qoqANPEphrin type-A receptor 32.7.10.10.457
3w33W19Epidermal growth factor receptor2.7.10.10.457
4fv9E71Mitogen-activated protein kinase 12.7.11.240.457
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.456
4o0uADNAurora kinase A2.7.11.10.456
3keuATPPyridoxal kinase2.7.1.350.455
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4hge15VTyrosine-protein kinase JAK2/0.455
2acxANPG protein-coupled receptor kinase 62.7.11.160.454
3mtfA3FActivin receptor type-12.7.11.300.454
3nszANPCasein kinase II subunit alpha2.7.11.10.454
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.454
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.454
4zasTYDCalS13/0.454
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2izsBRQCasein kinase I isoform gamma-32.7.11.10.453
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.453
4bewCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.453
4fvqATPTyrosine-protein kinase JAK2/0.453
4oavACP2-5A-dependent ribonuclease3.1.260.453
3bu5ATPInsulin receptor2.7.10.10.452
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.452
4e6q0NVTyrosine-protein kinase JAK2/0.452
4qnyANPMitogen activated protein kinase, putative/0.452
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2y5s78HDihydropteroate synthase/0.451
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.451
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.451
3r1yX76Cyclin-dependent kinase 22.7.11.220.451
5awmANPStress-activated protein kinase JNK2.7.11.240.451
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.450
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.450
3lu7IPXSerum albumin/0.450
4btjADPTau-tubulin kinase 12.7.11.10.450
2cjmATPCyclin-dependent kinase 22.7.11.220.449
2wqeADPAurora kinase A2.7.11.10.449
3orkAGSSerine/threonine protein kinase/0.449
4bbfO19Tyrosine-protein kinase JAK2/0.449
4bcmT7ZCyclin-dependent kinase 22.7.11.220.449
4c3pACPAurora kinase A2.7.11.10.449
1j7uANPAminoglycoside 3'-phosphotransferase2.7.1.950.448
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.448
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.448
3clyACPFibroblast growth factor receptor 2/0.448
4aguD15Cyclin-dependent kinase-like 1/0.448
5eg3ACPFibroblast growth factor receptor 2/0.448
5eoxADPType 4 fimbrial biogenesis protein PilM/0.448
1xq6NAPUncharacterized protein At5g02240/0.447
2w5aADPSerine/threonine-protein kinase Nek22.7.11.10.447
3fpbCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.447
3qj7UMPThymidylate synthase ThyA/0.447
3w32W32Epidermal growth factor receptor2.7.10.10.447
5cnoANPEpidermal growth factor receptor2.7.10.10.447
5i4nATPTyrosine-protein kinase JAK2/0.447
1lolXMPOrotidine 5'-phosphate decarboxylase4.1.1.230.446
3dd125DGlycogen phosphorylase, liver form2.4.1.10.446
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.446
4ic7ANPMitogen-activated protein kinase 72.7.11.240.446
4j95ACPFibroblast growth factor receptor 2/0.446
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.446
4xjxATPType I restriction enzyme EcoR124II R protein3.1.21.30.446
5dnrATPAurora kinase A2.7.11.10.446
4c4h7RODual specificity protein kinase TTK2.7.12.10.445
4crsAGSSerine/threonine-protein kinase N22.7.11.130.445
4gyiADPUncharacterized protein/0.445
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
1hk1T44Serum albumin/0.444
2etm7PYFocal adhesion kinase 12.7.10.20.444
2j0lANPFocal adhesion kinase 12.7.10.20.444
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4deeADPAurora kinase A2.7.11.10.444
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.444
2csnCKICasein kinase I homolog 12.7.11.10.443
2qo9ANPEphrin type-A receptor 32.7.10.10.443
2x1eX1EAcyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form2.3.1.1640.443
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.443
3c50ADPRhodopsin kinase/0.443
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.443
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.443
4eomATPCyclin-dependent kinase 22.7.11.220.443
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.443
5e92ANPTGF-beta receptor type-22.7.11.300.443
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.442
1sxjAGSReplication factor C subunit 1/0.442
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2ojj82AMitogen-activated protein kinase 12.7.11.240.442
2pulACPMethylthioribose kinase2.7.1.1000.442
2q4bNAPUncharacterized protein At5g02240/0.442
3datMTXDihydrofolate reductase/0.442
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.442
3my5RFZCyclin-dependent kinase 22.7.11.220.442
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.442
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.442
4lyn1YGCyclin-dependent kinase 22.7.11.220.441
4rpgFADUDP-galactopyranose mutase5.4.99.90.441
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.440
2pupADPMethylthioribose kinase2.7.1.1000.440
2q6bHR23-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.440
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3vthAPCCarbamoyltransferase/0.440
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4i3zADPCyclin-dependent kinase 22.7.11.220.440
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
5ap7SVEDual specificity protein kinase TTK2.7.12.10.440
5l8lADPAurora kinase A2.7.11.10.440