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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vrx447Aurora kinase B-A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2vrx447Aurora kinase B-A2.7.11.11.000
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.501
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.500
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.484
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.484
4jbpYPHAurora kinase A2.7.11.10.484
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.480
3w2o03PEpidermal growth factor receptor2.7.10.10.479
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.477
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.473
2c6eHPMAurora kinase A2.7.11.10.472
4gt3ATPMitogen-activated protein kinase 12.7.11.240.470
4jboWPHAurora kinase A2.7.11.10.461
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.460
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.460
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.459
4c3pACPAurora kinase A2.7.11.10.458
4aotGW8Serine/threonine-protein kinase 102.7.11.10.453
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.452
3ztxZTXAurora kinase B-A2.7.11.10.449
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.444
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.442
4b8mVX6Aurora kinase B-A2.7.11.10.442
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.440