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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.17

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.171.000
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.569
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.550
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.548
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.537
2vtqLZACyclin-dependent kinase 22.7.11.220.524
2vu3LZECyclin-dependent kinase 22.7.11.220.522
4ez50RSCyclin-dependent kinase 62.7.11.220.517
4jqeANPCasein kinase II subunit alpha2.7.11.10.516
4bcqTJFCyclin-dependent kinase 22.7.11.220.511
4bcmT7ZCyclin-dependent kinase 22.7.11.220.510
2uzbC75Cyclin-dependent kinase 22.7.11.220.509
4grb0XGCasein kinase II subunit alpha2.7.11.10.506
2w05FRTCyclin-dependent kinase 22.7.11.220.504
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.504
2cchATPCyclin-dependent kinase 22.7.11.220.502
4ic7ANPMitogen-activated protein kinase 72.7.11.240.502
4j95ACPFibroblast growth factor receptor 2/0.502
2zjwREFCasein kinase II subunit alpha2.7.11.10.500
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.500
5cvfATPCasein kinase II subunit alpha2.7.11.10.500
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.499
4hvi19STyrosine-protein kinase JAK32.7.10.20.499
3be9P04Casein kinase II subunit alpha2.7.11.10.498
3u4uLNHCasein kinase II subunit alpha2.7.11.10.495
1aq1STUCyclin-dependent kinase 22.7.11.220.493
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.493
3rkb12ZCyclin-dependent kinase 22.7.11.220.493
4ix6ADPUncharacterized protein/0.493
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.492
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.492
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.492
3c4xATPRhodopsin kinase/0.491
4bchT7ZCyclin-dependent kinase 92.7.11.220.491
4fkv61KCyclin-dependent kinase 22.7.11.220.491
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.490
1fvv107Cyclin-dependent kinase 22.7.11.220.489
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.489
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.488
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.487
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.487
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.486
2ijmADPFocal adhesion kinase 12.7.10.20.485
3q9xEMOCasein kinase II subunit alpha2.7.11.10.485
4j99ACPFibroblast growth factor receptor 2/0.485
2ojj82AMitogen-activated protein kinase 12.7.11.240.484
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.484
4aguD15Cyclin-dependent kinase-like 1/0.482
2vv9IM9Cyclin-dependent kinase 22.7.11.220.481
3at4CCKCasein kinase II subunit alpha2.7.11.10.480
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.480
2pvnP63Casein kinase II subunit alpha2.7.11.10.479
3begANPSRSF protein kinase 12.7.11.10.479
3t8oATPRhodopsin kinase/0.479
4bcnT9NCyclin-dependent kinase 22.7.11.220.479
2pvmP29Casein kinase II subunit alpha2.7.11.10.478
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.477
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.476
2fvdLIACyclin-dependent kinase 22.7.11.220.476
2uzdC85Cyclin-dependent kinase 22.7.11.220.476
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.476
3qxpX64Cyclin-dependent kinase 22.7.11.220.475
1finATPCyclin-dependent kinase 22.7.11.220.474
3lltANPProtein serine/threonine kinase-1/0.474
3nux3NVCyclin-dependent kinase 62.7.11.220.473
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.472
4erwSTUCyclin-dependent kinase 22.7.11.220.472
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.471
2ckeIQUDeath-associated protein kinase 2/0.470
4dtaADNAPH(2'')-Id/0.470
1oiyN41Cyclin-dependent kinase 22.7.11.220.469
2w17I19Cyclin-dependent kinase 22.7.11.220.468
2x1nX1NCyclin-dependent kinase 22.7.11.220.468
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.468
4eooATPCyclin-dependent kinase 22.7.11.220.468
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.468
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.468
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.467
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.467
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.467
3a62STURibosomal protein S6 kinase beta-12.7.11.10.467
3my5RFZCyclin-dependent kinase 22.7.11.220.467
4hgs15GCasein kinase I isoform gamma-32.7.11.10.467
2cjmATPCyclin-dependent kinase 22.7.11.220.466
2i40BLZCyclin-dependent kinase 22.7.11.220.466
3zewSTUEphrin type-B receptor 42.7.10.10.466
4q5hANPProtein kinase OspG2.70.466
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.465
3le62BZCyclin-dependent kinase 22.7.11.220.465
3rak03ZCyclin-dependent kinase 22.7.11.220.465
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.465
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.465
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.465
5av2KMPDeath-associated protein kinase 12.7.11.10.465
2j0m4STFocal adhesion kinase 12.7.10.20.464
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.464
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3igoANPCalmodulin-domain protein kinase 1, putative/0.463
3pe2E1BCasein kinase II subunit alpha2.7.11.10.463
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.462
1pkdUCNCyclin-dependent kinase 22.7.11.220.461
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.461
2wihP48Cyclin-dependent kinase 22.7.11.220.461
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.461
2j0lANPFocal adhesion kinase 12.7.10.20.460
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.459
4jia1K3Tyrosine-protein kinase JAK2/0.459
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.459
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.458
3lfqA28Cyclin-dependent kinase 22.7.11.220.458
3s2pPMUCyclin-dependent kinase 22.7.11.220.458
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.458
1m2pHNACasein kinase II subunit alpha2.7.11.10.457
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.457
4bcoT6QCyclin-dependent kinase 22.7.11.220.457
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.457
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.456
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3c4zADPRhodopsin kinase/0.455
3i60E86Mitogen-activated protein kinase 12.7.11.240.455
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.455
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.455
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.455
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.454
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.454
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.453
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.453
2itqITQEpidermal growth factor receptor2.7.10.10.452
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.452
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.452
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
1gih1PUCyclin-dependent kinase 22.7.11.220.451
2c4g514Cyclin-dependent kinase 22.7.11.220.451
2c5nCK8Cyclin-dependent kinase 22.7.11.220.451
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.451
3zep1NXTyrosine-protein kinase JAK32.7.10.20.451
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.449
1oitHDTCyclin-dependent kinase 22.7.11.220.449
1v1k3FPCyclin-dependent kinase 22.7.11.220.449
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.449
2pmoHMDProtein kinase 7/0.449
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3r7yZ04Cyclin-dependent kinase 22.7.11.220.449
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.449
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1eh4IC1Casein kinase I homolog 12.7.11.10.448
1gii1PUCyclin-dependent kinase 22.7.11.220.448
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.448
2vttLZDCyclin-dependent kinase 22.7.11.220.448
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.448
3gubGUBDeath-associated protein kinase 12.7.11.10.448
3mb714ICasein kinase II subunit alpha2.7.11.10.448
4fv6E57Mitogen-activated protein kinase 12.7.11.240.448
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4kbk1QGCasein kinase I isoform delta2.7.11.10.448
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.448
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.447
4fx360KCyclin-dependent kinase 22.7.11.220.447
4hvh19RTyrosine-protein kinase JAK32.7.10.20.447
1zrzBI1Protein kinase C iota type2.7.11.130.446
2izuP01Casein kinase I isoform gamma-32.7.11.10.446
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.446
2yaaATPDeath-associated protein kinase 2/0.446
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.446
3nszANPCasein kinase II subunit alpha2.7.11.10.446
3nup3NUCyclin-dependent kinase 62.7.11.220.446
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.446
4anmWULCasein kinase II subunit alpha2.7.11.10.446
4ix5ANPUncharacterized protein/0.446
1pjkANPCasein kinase II subunit alpha2.7.11.10.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3h3t16HCollagen type IV alpha-3-binding protein/0.445
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.445
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2cciATPCyclin-dependent kinase 22.7.11.220.444
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.444
4ogrADNCyclin-dependent kinase 92.7.11.220.444
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
5cu6ATPCasein kinase II subunit alpha2.7.11.10.444
1e9hINRCyclin-dependent kinase 22.7.11.220.443
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.443
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.443
3lfsA07Cyclin-dependent kinase 22.7.11.220.443
4o0wADNAurora kinase A2.7.11.10.443
1bygSTUTyrosine-protein kinase CSK/0.442
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.442
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
5e8ySTUTGF-beta receptor type-22.7.11.300.442
1pxoCK7Cyclin-dependent kinase 22.7.11.220.441
1rfvADPPyridoxal kinase2.7.1.350.441
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.441
2c6tDT5Cyclin-dependent kinase 22.7.11.220.441
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.441
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.441
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1pmn984Mitogen-activated protein kinase 102.7.11.240.440
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.440
2bujSTUSerine/threonine-protein kinase 16/0.440
2etrY27Rho-associated protein kinase 12.7.11.10.440
2in6839Wee1-like protein kinase2.7.10.20.440
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.440
3s1h56ZCyclin-dependent kinase 22.7.11.220.440
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.440
3tnwF18Cyclin-dependent kinase 22.7.11.220.440
3zh8C58Protein kinase C iota type2.7.11.130.440
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440