sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2vk8 | TPP | Pyruvate decarboxylase isozyme 1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2vk8 | TPP | Pyruvate decarboxylase isozyme 1 | / | 1.000 | |
| 1ovm | TPP | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.565 | |
| 2w93 | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.554 | |
| 1pvd | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.500 | |
| 4k9n | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.481 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.475 | |
| 5ahk | TPP | Acetolactate synthase II, large subunit | / | 0.473 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.466 | |
| 2vk4 | TPP | Pyruvate decarboxylase | 4.1.1.1 | 0.465 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.463 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 4juf | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.458 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.457 | |
| 5ej4 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.456 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.455 | |
| 1xdp | ATP | Polyphosphate kinase | / | 0.452 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 1qpb | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.451 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.451 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.450 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.449 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.447 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.447 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.446 | |
| 2ji6 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.446 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.444 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.443 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.441 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.440 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 |