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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vetUMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2vetUMPThymidylate synthase/1.000
1bduDURThymidylate synthase/0.721
1aobDDUThymidylate synthase/0.666
1bidUMPThymidylate synthase/0.663
1jmgUMPThymidylate synthase/0.537
1tsxUMPThymidylate synthase/0.528
3bgxTMPThymidylate synthase/0.520
1jmfUMPThymidylate synthase/0.517
1jmiUMPThymidylate synthase/0.516
2g8aUMPThymidylate synthase/0.500
1njaDCMThymidylate synthase/0.499
1tsyUMPThymidylate synthase/0.495
1jmhUMPThymidylate synthase/0.491
1tsvUMPThymidylate synthase/0.491
1njbUMPThymidylate synthase/0.486
1tysTMPThymidylate synthase/0.485
2g89UMPThymidylate synthase/0.483
1lcbTMPThymidylate synthase/0.482
2g86UMPThymidylate synthase/0.482
1bp6UMPThymidylate synthase/0.476
1bpjUMPThymidylate synthase/0.475
1njdUMPThymidylate synthase/0.469
1njeDCMThymidylate synthase/0.461
1vzaUMPThymidylate synthase/0.461
1vzbUMPThymidylate synthase/0.460
3qj7UMPThymidylate synthase ThyA/0.460
2tdmUMPThymidylate synthase/0.448
4lrrCF9Thymidylate synthase/0.444
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4dq1UMPThymidylate synthase/0.441