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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vd7PD2Lysine-specific demethylase 4A1.14.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2vd7PD2Lysine-specific demethylase 4A1.14.111.000
4lxlPD2Lysine-specific demethylase 4B1.14.110.630
4bis8HQLysine-specific demethylase 4A1.14.110.624
4gd40WSLysine-specific demethylase 4A1.14.110.619
2wwjY28Lysine-specific demethylase 4A/0.609
4d6qPD2Lysine-specific demethylase 4D1.14.110.594
3rvhHQ2Lysine-specific demethylase 4A1.14.110.593
3pdqKC6Lysine-specific demethylase 4A1.14.110.556
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.489
2ea2F77Methionine aminopeptidase 2/0.475
3af1GDPPantothenate kinase2.7.1.330.466
1yw8A75Methionine aminopeptidase 2/0.450
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.450
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.450
2ea4F79Methionine aminopeptidase 2/0.449
4tx9AMZPhosphoribosyl isomerase A/0.449
4bfwZVWPantothenate kinase2.7.1.330.448
4askK0ILysine-specific demethylase 6B1.14.110.447
4bfzZVZPantothenate kinase2.7.1.330.447
1u1gBBBUridine phosphorylase2.4.2.30.446
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.444
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.443
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.442
3enkUPGUDP-glucose 4-epimerase/0.441
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.440
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.440