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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2uxwTH3Very long-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2uxwTH3Very long-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.91.000
3t2zFADSulfide-quinone reductase/0.490
2npxNADNADH peroxidase1.11.1.10.487
3abiNADUncharacterized protein/0.482
1tj0FADBifunctional protein PutA1.5.5.20.477
2npaMMBPeroxisome proliferator-activated receptor alpha/0.475
2rs1W84Genome polyprotein/0.475
3t2yFADSulfide-quinone reductase/0.475
1k7l544Peroxisome proliferator-activated receptor alpha/0.474
3kduNKSPeroxisome proliferator-activated receptor alpha/0.474
1fm4DXCMajor pollen allergen Bet v 1-L/0.473
1iy8NADLevodione reductase/0.473
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.472
5a3cNADSIR2 family protein/0.472
2wetFADTryptophan 5-halogenase/0.471
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.471
1ipeNDPTropinone reductase 21.1.1.2360.469
2rewREWPeroxisome proliferator-activated receptor alpha/0.469
2rr1W8RGenome polyprotein/0.469
3syiFADSulfide-quinone reductase/0.468
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.467
3sz0FADSulfide-quinone reductase/0.467
2ba9FADPutative aminooxidase/0.466
3b70NAPEnoyl reductase LovC10.466
3b6zCO7Enoyl reductase LovC10.465
3kpkFADSulfide-quinone reductase/0.465
4j4bNAIUncharacterized protein/0.465
1osvCHCBile acid receptor/0.464
2b9xFADPutative aminooxidase/0.464
5lc1NADL-threonine 3-dehydrogenase/0.463
2rm2W43Genome polyprotein/0.461
2y60M8FIsopenicillin N synthase1.21.3.10.461
4oztP1AEcdysone receptor, putative/0.460
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.459
2f1kNAPPrephenate dehydrogenase/0.459
2ozuACOHistone acetyltransferase KAT6A/0.459
2znnS44Peroxisome proliferator-activated receptor alpha/0.459
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.458
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.458
4c77N01Phenylacetone monooxygenase1.14.13.920.458
1rwbNADGlucose 1-dehydrogenase1.1.1.470.457
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.457
3uklFADUDP-galactopyranose mutase/0.457
1q0qNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.456
2bi4NADLactaldehyde reductase1.1.1.770.456
2ft9CHDFatty acid-binding protein 2, liver/0.456
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.456
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.456
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.456
2jb4A14Isopenicillin N synthase1.21.3.10.455
3d5fL41Peroxisome proliferator-activated receptor delta/0.455
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.455
4u8lFDAUDP-galactopyranose mutase/0.455
4g7gVFVLanosterol 14-alpha-demethylase/0.453
3tz3B36Acetyl-CoA carboxylase/0.452
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.452
1snyNAPLD36273p/0.451
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.451
4yntFDAGlucose oxidase, putative/0.451
5br4NADLactaldehyde reductase1.1.1.770.451
1ot7CHCBile acid receptor/0.450
1y0s331Peroxisome proliferator-activated receptor delta/0.450
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.450
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.450
3t2kFADSulfide-quinone reductase/0.450
4h6rFDAProline dehydrogenase/0.450
4jbiNDPAlcohol dehydrogenase (Zinc)/0.450
4jq3NAPAldo-keto reductase family 1 member C2/0.450
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1cf3FADGlucose oxidase1.1.3.40.449
1w6hTITPlasmepsin-23.4.23.390.449
2zb3NDPProstaglandin reductase 21.3.1.480.449
3wmxNADNAD dependent epimerase/dehydratase/0.449
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.449
4q73FADBifunctional protein PutA/0.449
4wx1FDAUDP-galactopyranose mutase/0.449
4kl9NDPDihydrofolate reductase1.5.1.30.448
4q71FADBifunctional protein PutA/0.448
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.447
1kkq471Peroxisome proliferator-activated receptor alpha/0.447
2lfoGCHFatty acid-binding protein, liver/0.447
3e2sFADBifunctional protein PutA1.5.5.20.447
3lqfNADGalactitol dehydrogenase/0.447
1xe55FEPlasmepsin-23.4.23.390.446
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.446
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.446
4gdeFDAUDP-galactopyranose mutase/0.446
1fm9570Peroxisome proliferator-activated receptor gamma/0.445
1n1eNDEGlycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal1.1.1.80.445
1nqaNADGlyceraldehyde-3-phosphate dehydrogenase/0.445
1q1wFADPutidaredoxin reductase1.18.1.50.445
1rrmAPRLactaldehyde reductase1.1.1.770.445
1xddAAYIntegrin alpha-L/0.445
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.445
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.445
3nf4FADAcyl-CoA dehydrogenase domain-containing protein/0.445
3t14FADSulfide-quinone reductase/0.445
3uteFADUDP-galactopyranose mutase/0.445
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4u8oFDAUDP-galactopyranose mutase/0.445
4xq9NADHomospermidine synthase2.5.1.440.445
2ardFDAFlavin-dependent tryptophan halogenase PrnA1.14.19.90.444
2fy4COACholine O-acetyltransferase2.3.1.60.444
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.444
2yxuATPPyridoxal kinase2.7.1.350.444
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.444
3r7kFDAProbable acyl CoA dehydrogenase/0.444
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.444
4gxs0YSGlutamate receptor 2/0.444
1hb3SCVIsopenicillin N synthase1.21.3.10.443
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.443
2he5NDPAldo-keto reductase family 1 member C211.1.10.443
2wsbNADGalactitol dehydrogenase/0.443
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.443
1e3eNAIAlcohol dehydrogenase 41.1.1.10.442
1rdt570Peroxisome proliferator-activated receptor gamma/0.442
2x8gFADThioredoxin glutathione reductase/0.442
3gw9VNILanosterol 14-alpha-demethylase/0.442
3ox4NADAlcohol dehydrogenase 21.1.1.10.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
4yddMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.442
1oaaNAPSepiapterin reductase1.1.1.1530.441
1zeoC01Peroxisome proliferator-activated receptor gamma/0.441
2ok7FADFerredoxin--NADP reductase, apicoplast/0.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
3ekuCY9Actin-5C/0.441
3k7tFAD6-hydroxy-L-nicotine oxidase/0.441
4li81XQTankyrase-12.4.2.300.441
4nxuADPMitochondrial dynamics protein MID51/0.441
4q72FADBifunctional protein PutA/0.441
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.441
1zemNADXylitol dehydrogenase/0.440
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.440
2xluNA7Putative flavin-containing monooxygenase/0.440
3aw9NADNAD-dependent epimerase/dehydratase/0.440
3d3wNAPL-xylulose reductase1.1.1.100.440
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
4bb3KKAIsopenicillin N synthase1.21.3.10.440
4dsgFADUncharacterized protein/0.440
4er6AW2Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.440
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.440