sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2tmn | 0FA | Thermolysin | 3.4.24.27 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2tmn | 0FA | Thermolysin | 3.4.24.27 | 1.000 | |
| 6tmn | 0PI | Thermolysin | 3.4.24.27 | 0.839 | |
| 4tmn | 0PK | Thermolysin | 3.4.24.27 | 0.826 | |
| 4tln | LNO | Thermolysin | 3.4.24.27 | 0.766 | |
| 3t8d | UBV | Thermolysin | 3.4.24.27 | 0.643 | |
| 4d9w | X32 | Thermolysin | 3.4.24.27 | 0.629 | |
| 3t74 | UBY | Thermolysin | 3.4.24.27 | 0.625 | |
| 3t8h | UBS | Thermolysin | 3.4.24.27 | 0.625 | |
| 1qf2 | TI3 | Thermolysin | 3.4.24.27 | 0.622 | |
| 4h57 | 0PJ | Thermolysin | 3.4.24.27 | 0.616 | |
| 3t87 | UBZ | Thermolysin | 3.4.24.27 | 0.615 | |
| 3t8c | UBW | Thermolysin | 3.4.24.27 | 0.606 | |
| 3fgd | BYA | Thermolysin | 3.4.24.27 | 0.600 | |
| 3for | ZNP | Thermolysin | 3.4.24.27 | 0.591 | |
| 4b52 | RDF | Bacillolysin | / | 0.553 | |
| 3f28 | S7B | Thermolysin | 3.4.24.27 | 0.530 | |
| 3f2p | S3B | Thermolysin | 3.4.24.27 | 0.525 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 4zr5 | RDF | Neprilysin | / | 0.470 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.462 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.461 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.459 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.456 | |
| 3bmo | NAP | Pteridine reductase | / | 0.455 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.452 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.452 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.451 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.450 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3mp3 | HGG | Hydroxymethylglutaryl-CoA lyase, mitochondrial | 4.1.3.4 | 0.448 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.448 | |
| 4a5l | NDP | Thioredoxin reductase | / | 0.448 | |
| 1c7o | PPG | Hemolysin | / | 0.447 | |
| 1n2g | APC | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.447 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.447 | |
| 3mx5 | UTP | Nucleoprotein | / | 0.447 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.447 | |
| 4ca5 | 3EF | Angiotensin-converting enzyme | 3.2.1 | 0.447 | |
| 3u9y | 09L | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4ca7 | 3EF | Angiotensin-converting enzyme | 3.4.15.1 | 0.446 | |
| 4h4t | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.446 | |
| 4dja | FAD | (6-4) photolyase | / | 0.445 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.444 | |
| 2wb2 | FAD | RE11660p | / | 0.444 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4j2w | FAD | Kynurenine 3-monooxygenase | / | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2x95 | X95 | Angiotensin-converting enzyme | 3.4.15.1 | 0.442 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.441 | |
| 1nhq | FAD | NADH peroxidase | 1.11.1.1 | 0.441 | |
| 1q3a | NGH | Stromelysin-2 | 3.4.24.22 | 0.441 | |
| 1eio | GCH | Gastrotropin | / | 0.440 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.440 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.440 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.440 |