sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2rtg | BTN | Streptavidin |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2rtg | BTN | Streptavidin | / | 1.000 | |
| 2izg | BTN | Streptavidin | / | 0.779 | |
| 2izl | IMI | Streptavidin | / | 0.738 | |
| 2rtd | BTN | Streptavidin | / | 0.731 | |
| 2izh | BTN | Streptavidin | / | 0.712 | |
| 2rte | BTN | Streptavidin | / | 0.708 | |
| 2rtf | BTN | Streptavidin | / | 0.697 | |
| 2izf | BTN | Streptavidin | / | 0.694 | |
| 1sre | HAB | Streptavidin | / | 0.671 | |
| 1lcw | SHM | Streptavidin | / | 0.667 | |
| 2rto | IMI | Streptavidin | / | 0.665 | |
| 2rtp | IMI | Streptavidin | / | 0.660 | |
| 3ry2 | BTN | Streptavidin | / | 0.656 | |
| 4gda | BTN | Streptavidin | / | 0.653 | |
| 2c4i | BTN | Avidin | / | 0.651 | |
| 1mk5 | BTN | Streptavidin | / | 0.650 | |
| 2rti | GLL | Streptavidin | / | 0.645 | |
| 1i9h | BNI | Streptavidin | / | 0.640 | |
| 1stp | BTN | Streptavidin | / | 0.638 | |
| 2rtn | IMI | Streptavidin | / | 0.635 | |
| 1sri | DMB | Streptavidin | / | 0.629 | |
| 1srg | MHB | Streptavidin | / | 0.627 | |
| 3wyq | BTN | Streptavidin | / | 0.626 | |
| 4bx7 | B4F | Streptavidin | / | 0.626 | |
| 4dne | DTB | Streptavidin | / | 0.626 | |
| 2rtr | IMI | Streptavidin | / | 0.625 | |
| 1srh | MOB | Streptavidin | / | 0.622 | |
| 2y3f | BTN | Streptavidin | / | 0.618 | |
| 3wzn | BTN | Streptavidin | / | 0.617 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.615 | |
| 1df8 | BTN | Streptavidin | / | 0.614 | |
| 1srj | NAB | Streptavidin | / | 0.612 | |
| 1rxh | BNI | Streptavidin | / | 0.610 | |
| 1swt | BTN | Streptavidin | / | 0.606 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.605 | |
| 1srf | MTB | Streptavidin | / | 0.604 | |
| 1luq | BTN | Streptavidin | / | 0.599 | |
| 2rtq | IMI | Streptavidin | / | 0.598 | |
| 1lcz | BH7 | Streptavidin | / | 0.595 | |
| 2uz2 | BTN | Avd protein | / | 0.584 | |
| 4z28 | BTN | Hoefavidin | / | 0.572 | |
| 1avd | BTN | Avidin | / | 0.567 | |
| 2avi | BTN | Avidin | / | 0.566 | |
| 1swp | BTQ | Streptavidin | / | 0.565 | |
| 2uyw | BTN | Avd protein | / | 0.565 | |
| 1nqm | BTN | Streptavidin | / | 0.564 | |
| 2izj | BTN | Streptavidin | / | 0.563 | |
| 2izi | BTN | Streptavidin | / | 0.562 | |
| 1swp | BTN | Streptavidin | / | 0.557 | |
| 3t2w | BTN | Avidin/streptavidin | / | 0.557 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.556 | |
| 3rdq | DTB | Streptavidin | / | 0.556 | |
| 3ew2 | BTN | Hypothetical conserved protein | / | 0.555 | |
| 1n9m | BTN | Streptavidin | / | 0.552 | |
| 1nc9 | IMI | Streptavidin | / | 0.548 | |
| 1swr | BTN | Streptavidin | / | 0.545 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.545 | |
| 1swe | BTN | Streptavidin | / | 0.538 | |
| 2rtm | IMI | Streptavidin | / | 0.535 | |
| 1swn | BTN | Streptavidin | / | 0.534 | |
| 1ndj | BTN | Streptavidin | / | 0.527 | |
| 2zsc | BTN | Tamavidin2 | / | 0.526 | |
| 4gd9 | BTN | Streptavidin | / | 0.524 | |
| 2izk | GLL | Streptavidin | / | 0.520 | |
| 1n43 | BTN | Streptavidin | / | 0.516 | |
| 2rtk | GLL | Streptavidin | / | 0.516 | |
| 1mep | BTN | Streptavidin | / | 0.512 | |
| 1swd | BTN | Streptavidin | / | 0.510 | |
| 4yvb | BTN | Streptavidin | / | 0.508 | |
| 2a5c | 8DA | Avidin | / | 0.507 | |
| 4bj8 | BTN | Avidin | / | 0.499 | |
| 2rtl | IMI | Streptavidin | / | 0.498 | |
| 2jgs | BTN | Avidin | / | 0.497 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.495 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.493 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.492 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.492 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.490 | |
| 2toh | HBI | Tyrosine 3-monooxygenase | 1.14.16.2 | 0.487 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.487 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.485 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.484 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.484 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.484 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.483 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.482 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.481 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.479 | |
| 3up0 | D7S | aceDAF-12 | / | 0.479 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.478 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.478 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.478 | |
| 3wyp | BSO | Streptavidin | / | 0.478 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.477 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.476 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.476 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.476 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.475 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.475 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.475 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.474 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.473 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.473 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.472 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.472 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.472 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.472 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.471 | |
| 1r2j | FAD | FkbI | / | 0.471 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.471 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.470 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.469 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.469 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.469 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.469 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.468 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.468 | |
| 4xd1 | T3Q | Qdtf | / | 0.468 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.467 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.467 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.467 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.467 | |
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.467 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.466 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.466 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4xcz | T3Q | Qdtf | / | 0.466 | |
| 1e2n | RCA | Thymidine kinase | / | 0.465 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.465 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.465 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.465 | |
| 1axw | MTX | Thymidylate synthase | / | 0.464 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.464 | |
| 4b1i | A8P | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.464 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.463 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.462 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.462 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.462 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.462 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.462 | |
| 4rhe | FMN | Flavin prenyltransferase UbiX | / | 0.462 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.462 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.461 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.461 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.461 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.461 | |
| 5egh | PC | Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 | / | 0.461 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.460 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.460 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.460 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.459 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.459 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.459 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.459 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.459 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.459 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.459 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.458 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.458 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.458 | |
| 1zdw | FLV | Prenyltransferase | / | 0.458 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.458 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.458 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.458 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.458 | |
| 1lke | DOG | Bilin-binding protein | / | 0.457 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.457 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.457 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 3f0r | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.457 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.457 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.457 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.457 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.457 | |
| 4mry | CEI | Obelin | / | 0.457 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1hni | AAA | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 1osv | CHC | Bile acid receptor | / | 0.456 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.456 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.456 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.456 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.456 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.455 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.455 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.455 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2jdv | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2pla | NAD | Glycerol-3-phosphate dehydrogenase 1-like protein | / | 0.455 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.455 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.455 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.455 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.455 | |
| 5iqg | GDP | Bifunctional AAC/APH | 2.3.1 | 0.455 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.454 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.454 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 1kzi | THG | Thymidylate synthase | / | 0.454 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.454 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.454 | |
| 1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.454 | |
| 1tys | DHF | Thymidylate synthase | / | 0.454 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.454 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.454 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.454 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.454 | |
| 4kxj | P34 | Nucleoprotein | / | 0.454 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.454 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.453 | |
| 2hvd | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.453 | |
| 2kce | D16 | Thymidylate synthase | / | 0.453 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.453 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.452 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.452 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2rbe | ZMG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.452 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.452 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.452 | |
| 3znq | SS8 | D-amino-acid oxidase | 1.4.3.3 | 0.452 | |
| 4ap3 | FAD | Steroid monooxygenase | / | 0.452 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.451 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 1ldq | SHM | Avidin | / | 0.451 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.451 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1ycg | FMN | Nitric oxide reductase | 1 | 0.451 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.451 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.451 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.451 | |
| 2ym1 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.451 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.451 | |
| 3vgw | NVZ | Avidin | / | 0.451 | |
| 1hv9 | UD1 | Bifunctional protein GlmU | / | 0.450 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.450 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.450 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.450 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.450 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.450 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.450 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.450 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1rej | B1L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.449 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.449 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.449 | |
| 5iqb | GNP | Bifunctional AAC/APH | 2.3.1 | 0.449 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.449 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.448 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 3srz | UPG | Toxin A | / | 0.448 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.448 | |
| 2acw | UPG | Glycosyltransferase | / | 0.447 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.447 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.447 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3tfq | 07M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4avl | TMP | Polymerase acidic protein | / | 0.447 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.447 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.447 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.447 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.447 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1s9e | ADB | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.446 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.446 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.446 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.446 | |
| 4ivr | N50 | Thymidine kinase | / | 0.446 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.446 | |
| 4ubu | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.446 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.446 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.446 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.446 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.445 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.445 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.445 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.445 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.445 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.445 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.445 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.445 | |
| 3bhr | THG | Thymidylate synthase | / | 0.445 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.445 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.445 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.445 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3i1y | 33N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3ngu | ADP | Nucleoside diphosphate kinase | / | 0.445 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.445 | |
| 3rup | ADP | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.445 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1s36 | CEI | Obelin | / | 0.444 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.444 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.444 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4hdr | DMD | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | / | 0.444 | |
| 4hdr | DMD | ArsB | / | 0.444 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.444 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 5iqa | GNP | Bifunctional AAC/APH | 2.3.1 | 0.444 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.444 | |
| 1f28 | F89 | Thymidylate synthase | 2.1.1.45 | 0.443 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.443 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.443 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.443 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 3arv | SAU | Chitinase A | / | 0.443 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3up3 | XCA | aceDAF-12 | / | 0.443 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.443 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.443 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.443 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.443 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.443 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.443 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.443 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.442 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 1zoy | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.442 | |
| 1zoy | UQ1 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 0.442 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3rdo | BTN | Streptavidin | / | 0.442 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.442 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.442 | |
| 1c7o | PPG | Hemolysin | / | 0.441 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.441 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.441 | |
| 1nen | DNT | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.441 | |
| 1nen | DNT | Succinate dehydrogenase cytochrome b556 subunit | / | 0.441 | |
| 1qzf | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 2q5q | KPV | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.441 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.441 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 3dv0 | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.441 | |
| 3dv0 | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.441 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.441 | |
| 4edz | 0O5 | Hematopoietic prostaglandin D synthase | / | 0.441 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 4rtj | SFG | DNA adenine methylase | 2.1.1.72 | 0.441 | |
| 4rtm | SAM | DNA adenine methylase | 2.1.1.72 | 0.441 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.441 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.441 | |
| 1ddt | APU | Diphtheria toxin | / | 0.440 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1lqa | NDP | Protein tas | / | 0.440 | |
| 1n0u | SO1 | Elongation factor 2 | / | 0.440 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1sbr | VIB | Putative HMP/thiamine-binding protein YkoF | / | 0.440 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.440 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1xp8 | AGS | Protein RecA | / | 0.440 | |
| 2dpm | SAM | Modification methylase DpnIIA | 2.1.1.72 | 0.440 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2rht | C1E | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.440 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.440 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.440 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.440 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3eks | CY9 | Actin-5C | / | 0.440 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 4wso | NAD | Probable nicotinate-nucleotide adenylyltransferase | / | 0.440 | |
| 5fkk | TDC | Tetracycline repressor protein class D | / | 0.440 | |
| 5mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.440 |