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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2rg5279Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2rg5279Mitogen-activated protein kinase 14/1.000
4kip1R9Mitogen-activated protein kinase 14/0.595
3nww3NWMitogen-activated protein kinase 14/0.594
2rg6287Mitogen-activated protein kinase 14/0.586
3fln3FNMitogen-activated protein kinase 14/0.574
4kin1M8Mitogen-activated protein kinase 14/0.574
4aa5NQBMitogen-activated protein kinase 14/0.573
3iphG11Mitogen-activated protein kinase 14/0.563
3mpt1GKMitogen-activated protein kinase 14/0.563
4kiq1RAMitogen-activated protein kinase 14/0.561
3dt1P40Mitogen-activated protein kinase 14/0.560
3flzFLZMitogen-activated protein kinase 14/0.560
3ocgOCGMitogen-activated protein kinase 14/0.559
4aacAAVMitogen-activated protein kinase 14/0.559
3fmh533Mitogen-activated protein kinase 14/0.555
2balPQAMitogen-activated protein kinase 14/0.551
3fklFKLMitogen-activated protein kinase 14/0.546
3flyFLYMitogen-activated protein kinase 14/0.545
3l8xN4DMitogen-activated protein kinase 14/0.544
4lopSB4Mitogen-activated protein kinase 14/0.544
2qd9LGFMitogen-activated protein kinase 14/0.539
3fi4FI4Mitogen-activated protein kinase 14/0.537
3mvm39PMitogen-activated protein kinase 14/0.535
3uvp048Mitogen-activated protein kinase 14/0.535
3s4qNK0Mitogen-activated protein kinase 14/0.534
3fskRO6Mitogen-activated protein kinase 14/0.530
2ghlLIBMitogen-activated protein kinase 14/0.525
3flwFLWMitogen-activated protein kinase 14/0.520
4aa4QC0Mitogen-activated protein kinase 14/0.520
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.519
3hl7I47Mitogen-activated protein kinase 14/0.515
4loqSB4Mitogen-activated protein kinase 14/0.509
4tuvCPZCytochrome P450 1191.140.509
4looSB4Mitogen-activated protein kinase 14/0.508
3fmkFMKMitogen-activated protein kinase 14/0.507
1zyjBI5Mitogen-activated protein kinase 14/0.505
4jq7KJQEpidermal growth factor receptor2.7.10.10.505
1zz2B11Mitogen-activated protein kinase 14/0.503
3uyt0CKCasein kinase I isoform delta2.7.11.10.497
2gtnLIEMitogen-activated protein kinase 14/0.493
3mvl38PMitogen-activated protein kinase 14/0.493
1nzdUPGDNA beta-glucosyltransferase/0.492
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.492
4ku5DCC3-oxoacyl-[ACP] synthase III/0.491
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.488
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.488
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.485
4g7gVFVLanosterol 14-alpha-demethylase/0.484
2gs7ANPEpidermal growth factor receptor2.7.10.10.483
3bc3OPTCathepsin L13.4.22.150.482
3gbuATPUncharacterized sugar kinase PH14592.7.10.482
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.481
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.481
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.481
3jynNDPQuinone oxidoreductase/0.479
1nzfUPGDNA beta-glucosyltransferase/0.477
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
3hvcGG5Mitogen-activated protein kinase 14/0.477
3qlsNDPDihydrofolate reductase1.5.1.30.477
1ouk084Mitogen-activated protein kinase 14/0.476
3d7zGK5Mitogen-activated protein kinase 14/0.476
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2r0pK2CPutative FAD-monooxygenase/0.475
3gfeP37Mitogen-activated protein kinase 14/0.475
3iaeD7KBenzaldehyde lyase/0.475
2zb0GK3Mitogen-activated protein kinase 14/0.474
3bv2P38Mitogen-activated protein kinase 14/0.474
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.474
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.474
4g2fC07Ephrin type-A receptor 32.7.10.10.474
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.474
1e3eNAIAlcohol dehydrogenase 41.1.1.10.473
3mpaSB2Mitogen-activated protein kinase 14/0.473
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.473
1mg5NAIAlcohol dehydrogenase1.1.1.10.472
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.472
1agwSU2Fibroblast growth factor receptor 1/0.471
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.471
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.471
1hncGDNGlutathione S-transferase Mu 22.5.1.180.470
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.470
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.470
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.470
3gw9VNILanosterol 14-alpha-demethylase/0.470
3roc29AMitogen-activated protein kinase 14/0.470
4gevCB3Thymidylate synthase/0.470
2gtmLIDMitogen-activated protein kinase 14/0.469
3b70NAPEnoyl reductase LovC10.469
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
3adaNADSubunit alpha of sarocosine oxidase/0.468
1v9aSAHUncharacterized protein/0.467
1xddAAYIntegrin alpha-L/0.467
2qo9ANPEphrin type-A receptor 32.7.10.10.467
3ac1KZITyrosine-protein kinase Lck2.7.10.20.467
3ac2KSETyrosine-protein kinase Lck2.7.10.20.467
3bv3P39Mitogen-activated protein kinase 14/0.467
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.467
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.467
1bygSTUTyrosine-protein kinase CSK/0.466
1pjkANPCasein kinase II subunit alpha2.7.11.10.466
2cig1DGDihydrofolate reductase1.5.1.30.466
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.466
3nxxNDPDihydrofolate reductase1.5.1.30.466
4eh60ONMitogen-activated protein kinase 14/0.466
5a3cNADSIR2 family protein/0.466
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.465
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
3cvuFADRE11660p/0.465
3fmn530Mitogen-activated protein kinase 14/0.465
3gqvNAPEnoyl reductase LovC10.465
3zkyWT4Isopenicillin N synthase1.21.3.10.465
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.465
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.465
4jr3KJREpidermal growth factor receptor2.7.10.10.465
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
2c475IDCasein kinase I isoform gamma-2/0.464
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.464
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.464
2vn0TDZCytochrome P450 2C8/0.464
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.464
3ad9NADSubunit alpha of sarocosine oxidase/0.464
2wq7FADRE11660p/0.463
3l0lHC3Nuclear receptor ROR-gamma/0.463
4kbc1QJCasein kinase I isoform delta2.7.11.10.463
4kl9NDPDihydrofolate reductase1.5.1.30.463
1jpaANPEphrin type-B receptor 22.7.10.10.462
2c3qGTXGlutathione S-transferase theta-12.5.1.180.462
2d29FADAcyl-CoA dehydrogenase/0.462
2gstGPSGlutathione S-transferase Mu 12.5.1.180.462
3k4nFADPyranose 2-oxidase/0.462
3lshFADPyranose 2-oxidase/0.462
3nx4NAPPutative oxidoreductase/0.462
3qlrNDPDihydrofolate reductase1.5.1.30.462
3zuyTCHTransporter/0.462
4fqsLYAThymidylate synthase ThyA/0.462
4g3jVNTLanosterol 14-alpha-demethylase/0.462
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.462
4xiwAZMCarbonic anhydrase, alpha type/0.462
5a3bAPRSIR2 family protein/0.462
1hvyD16Thymidylate synthase2.1.1.450.461
1jioDEB6-deoxyerythronolide B hydroxylase/0.461
3au8NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.461
3hz5Z64Heat shock protein HSP 90-alpha/0.461
4e5kNADPhosphonate dehydrogenase1.20.1.10.461
4lxhC1EAlpha/beta hydrolase fold/0.461
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.461
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
2nq8ZIDEnoyl-ACP reductase/0.460
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.460
3hllI45Mitogen-activated protein kinase 14/0.460
3k4cFADPyranose 2-oxidase/0.460
3pm9FADPutative oxidoreductase/0.460
3uleC69Actin-related protein 3/0.460
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.460
5eccNAPDehydrofolate reductase type I/0.460
1qorNDPQuinone oxidoreductase 1/0.459
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.459
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.459
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.459
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.459
3lsiFADPyranose 2-oxidase/0.459
3qwbNDPProbable quinone oxidoreductase1.6.5.50.459
3w33W19Epidermal growth factor receptor2.7.10.10.459
4g3qUD1Bifunctional protein GlmU/0.459
1cx4CMPcAMP-dependent protein kinase type II-beta regulatory subunit/0.458
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.458
1txtCAAHMG-CoA synthase/0.458
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.458
2cduFADNADH oxidase/0.458
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.458
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
4ipw1G7Mycocyclosin synthase1.14.21.90.458
4y8wSTRSteroid 21-hydroxylase/0.458
5itzLOCTubulin beta-2B chain/0.458
1rx1NAPDihydrofolate reductase1.5.1.30.457
1tysDHFThymidylate synthase/0.457
2ittAEEEpidermal growth factor receptor2.7.10.10.457
2itvANPEpidermal growth factor receptor2.7.10.10.457
2wdzNADGalactitol dehydrogenase/0.457
4kbk1QGCasein kinase I isoform delta2.7.11.10.457
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1fm4DXCMajor pollen allergen Bet v 1-L/0.456
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.456
1rm5NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.456
2jb4A14Isopenicillin N synthase1.21.3.10.456
2vd5BI8Myotonin-protein kinase2.7.11.10.456
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.456
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.456
3d7kD7KBenzaldehyde lyase/0.456
3gstGPRGlutathione S-transferase Mu 12.5.1.180.456
3gwfFADCyclohexanone monooxygenase/0.456
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.456
3kb1ADPIron-sulfur cluster carrier protein/0.456
3p3zP3ZPutative cytochrome P450/0.456
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.456
4ki8ADP60 kDa chaperonin/0.456
5cvfATPCasein kinase II subunit alpha2.7.11.10.456
1m78NDPDihydrofolate reductase1.5.1.30.455
2ftoCB3Thymidylate synthase/0.455
3gc9B45Mitogen-activated protein kinase 112.7.11.240.455
3icrFADCoenzyme A disulfide reductase/0.455
3lqfNADGalactitol dehydrogenase/0.455
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.455
3vt7VDXVitamin D3 receptor/0.455
4irnFADAnaB/0.455
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.455
4ure1PSCyclohexanol dehydrogenase/0.455
1dr3TAPDihydrofolate reductase1.5.1.30.454
1fmlRTLRetinol dehydratase/0.454
1hopGCPAdenylosuccinate synthetase/0.454
1uymPU3Heat shock protein HSP 90-beta/0.454
2c0cNAPProstaglandin reductase 310.454
2fzwNADAlcohol dehydrogenase class-31.1.1.10.454
2g5cNADPrephenate dehydrogenase/0.454
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.454
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.454
3gggNADPrephenate dehydrogenase/0.454
3gobHXXDdmC/0.454
3pgiF41Endothiapepsin3.4.23.220.454
3t2zFADSulfide-quinone reductase/0.454
3vrwYS5Vitamin D3 receptor/0.454
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.454
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.454
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
4o701QKBromodomain-containing protein 4/0.454
4oplFDAConserved Archaeal protein/0.454
1m7qDQOMitogen-activated protein kinase 14/0.453
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
1zrzBI1Protein kinase C iota type2.7.11.130.453
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.453
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.453
2uxoTACHTH-type transcriptional regulator TtgR/0.453
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.453
3d8bADPFidgetin-like protein 13.6.40.453
3tdaPN0Cytochrome P450 2D6/0.453
3uvqFS8Mitogen-activated protein kinase 14/0.453
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.453
4o1mNADEnoyl-acyl carrier reductase/0.453
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.453
4xrgNADHomospermidine synthase2.5.1.440.453
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.452
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.452
1zdwFLVPrenyltransferase/0.452
2c12FADNitroalkane oxidase1.7.3.10.452
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.452
2uxuNARHTH-type transcriptional regulator TtgR/0.452
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.452
3bhrTHGThymidylate synthase/0.452
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.452
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3t2yFADSulfide-quinone reductase/0.452
3uwlFOZThymidylate synthase/0.452
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.452
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.452
4j4bNAIUncharacterized protein/0.452
4kb81QNCasein kinase I isoform delta2.7.11.10.452
1dr5NAPDihydrofolate reductase1.5.1.30.451
1gcoNADGlucose 1-dehydrogenase1.1.1.470.451
1kvkATPMevalonate kinase2.7.1.360.451
1pr9NAPL-xylulose reductase1.1.1.100.451
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.451
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.451
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.451
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.451
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.451
3raiX85Cyclin-dependent kinase 22.7.11.220.451
3stuDK3Methylketone synthase I/0.451
3tqaNDPDihydrofolate reductase/0.451
3zcw4A2Kinesin-like protein KIF11/0.451
3zh8C58Protein kinase C iota type2.7.11.130.451
4b7sQLECytochrome P450 monooxygenase PikC/0.451
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.451
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
5jlaNADPutative short-chain dehydrogenase/reductase/0.451
5kjcPFBAlcohol dehydrogenase E chain1.1.1.10.451
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.450
1dr2TAPDihydrofolate reductase1.5.1.30.450
1j39UPGDNA beta-glucosyltransferase/0.450
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.450
1osvCHCBile acid receptor/0.450
1tehNADAlcohol dehydrogenase class-31.1.1.10.450
1xzqFONtRNA modification GTPase MnmE3.6.50.450
1yb5NAPQuinone oxidoreductase1.6.5.50.450
2hcdBIVVitamin D3 receptor A/0.450
2hqpNDPDihydrofolate reductase1.5.1.30.450
2zb1GK4Mitogen-activated protein kinase 14/0.450
3bbrBHYGlutamate receptor 2/0.450
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.450
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.450
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.450
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.450
3u8w09JMitogen-activated protein kinase 14/0.450
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.450
4e5yNDPGDP-L-fucose synthase1.1.1.2710.450
4jbqVX6Aurora kinase A2.7.11.10.450
5eypLOCTubulin beta chain/0.450
5hwsNAP2-dehydropantoate 2-reductase/0.450
1cf3FADGlucose oxidase1.1.3.40.449
1cqp803Integrin alpha-L/0.449
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.449
1xe55FEPlasmepsin-23.4.23.390.449
1ywrLI9Mitogen-activated protein kinase 14/0.449
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.449
2ql6ADPNicotinamide riboside kinase 1/0.449
2vbdV10Isopenicillin N synthase1.21.3.10.449
2xx91NFGlutamate receptor 2/0.449
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.449
3d4pNADL-lactate dehydrogenase 11.1.1.270.449
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.449
3lpbNVBTyrosine-protein kinase JAK2/0.449
3q43D66M1 family aminopeptidase3.4.110.449
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4fidGDPG protein alpha subunit, putative/0.449
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.449
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
4i231C9Epidermal growth factor receptor2.7.10.10.449
4ly91YYGlucokinase regulatory protein/0.449
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1pdhFASp-hydroxybenzoate hydroxylase/0.448
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.448
2om9AJAPeroxisome proliferator-activated receptor gamma/0.448
2ozuACOHistone acetyltransferase KAT6A/0.448
2xa4AZ5Tyrosine-protein kinase JAK2/0.448
2ylxFADPhenylacetone monooxygenase1.14.13.920.448
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
3flsFLSMitogen-activated protein kinase 14/0.448
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.448
3w0jT08Vitamin D3 receptor/0.448
3wmxNADNAD dependent epimerase/dehydratase/0.448
4a81DXCMajor pollen allergen Bet v 1-A/0.448
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
4dymIYZActivin receptor type-12.7.11.300.448
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.448
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.448
4fv7E94Mitogen-activated protein kinase 12.7.11.240.448
4g3pUD1Bifunctional protein GlmU/0.448
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
4uyf73BBromodomain-containing protein 2/0.448
4xybNDPFormate dehydrogenase/0.448
4y93746Tyrosine-protein kinase/0.448
4yntFDAGlucose oxidase, putative/0.448
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.447
1ia3TQ5Dihydrofolate reductase1.5.1.30.447
1k6tXN1Gag-Pol polyprotein3.4.23.160.447
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.447
1txiTX5Vitamin D3 receptor/0.447
1zrqFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.447
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.447
2iyaZIOOleandomycin glycosyltransferase/0.447
2qoqANPEphrin type-A receptor 32.7.10.10.447
2xyuQ9GEphrin type-A receptor 42.7.10.10.447
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.447
3ak4NADNADH-dependent quinuclidinone reductase/0.447
3d84NDPDihydrofolate reductase1.5.1.30.447
3mdmFJZCholesterol 24-hydroxylase/0.447
3oibFDAPutative acyl-CoA dehydrogenase/0.447
3qm4PN0Cytochrome P450 2D6/0.447
3tqhNDPQuinone oxidoreductase/0.447
3u4cNDPNADPH-dependent reductase BacG/0.447
3uzp0CKCasein kinase I isoform delta2.7.11.10.447
3vtdTKDVitamin D3 receptor/0.447
3w5rLOAVitamin D3 receptor/0.447
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
4dfg0JVGag-Pol polyprotein3.4.23.160.447
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.447
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.447
4hjfC2EGGDEF family protein/0.447
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.447
4nieNBHNuclear receptor ROR-gamma/0.447
4ykfFADAlkyl hydroperoxide reductase subunit F1.8.10.447
5d3qGDPDynamin-13.6.5.50.447
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.446
1k6pXN3Gag-Pol polyprotein3.4.23.160.446
1xny191Propionyl-CoA carboxylase complex B subunit/0.446
2ath3EAPeroxisome proliferator-activated receptor gamma/0.446
2ebaFADPutative glutaryl-CoA dehydrogenase/0.446
2hdjNDPAldo-keto reductase family 1 member C2/0.446
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
2vwx7X4Ephrin type-B receptor 42.7.10.10.446
2w3wVG9Dihydrofolate reductase/0.446
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.446
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.446
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.446
2xw7NDPDihydrofolate reductase/0.446
3h3fNAIL-lactate dehydrogenase A chain1.1.1.270.446
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.446
3lovFADProtoporphyrinogen oxidase/0.446
3oy4017Gag-Pol polyprotein3.4.23.160.446
4b4w9L9Bifunctional protein FolD/0.446
4cavMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.446
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.446
4h6rFDAProline dehydrogenase/0.446
4tx9AMZPhosphoribosyl isomerase A/0.446
5fl3ADPPili retraction protein PilT/0.446
1iyzNDPProbable quinone oxidoreductase/0.445
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
1kgjFL8Transthyretin/0.445
1kzjCB3Thymidylate synthase/0.445
1nooCAHCamphor 5-monooxygenase1.14.15.10.445
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.445
1uyePU9Heat shock protein HSP 90-alpha/0.445
2givACOHistone acetyltransferase KAT8/0.445
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.445
2znnS44Peroxisome proliferator-activated receptor alpha/0.445
3e5rNADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic1.2.1.120.445
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.445
3rhhNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase/0.445
3sz0FADSulfide-quinone reductase/0.445
3uylTYDProbable NDP-rhamnosyltransferase/0.445
3vt65YIVitamin D3 receptor/0.445
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4hwkNAPSepiapterin reductase1.1.1.1530.445
4ia2BIVVitamin D3 receptor A/0.445
4nh82LCHeat shock protein HSP 90-alpha/0.445
4o2bLOCTubulin beta-2B chain/0.445
4uymVOR14-alpha sterol demethylase Cyp51B/0.445
4xq9NADHomospermidine synthase2.5.1.440.445
4yaiNAIC alpha-dehydrogenase/0.445
5iqiGNPBifunctional AAC/APH2.3.10.445
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.444
1c1dNAIPhenylalanine dehydrogenase/0.444
1ma0NADAlcohol dehydrogenase class-31.1.1.10.444
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.444
1nq14HYThyroid hormone receptor beta/0.444
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.444
1qjfACSIsopenicillin N synthase1.21.3.10.444
1zeoC01Peroxisome proliferator-activated receptor gamma/0.444
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.444
2gsdNADFormate dehydrogenase/0.444
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
2of2547Tyrosine-protein kinase Lck2.7.10.20.444
2of4979Tyrosine-protein kinase Lck2.7.10.20.444
2vcmM11Isopenicillin N synthase1.21.3.10.444
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3qaiXNNKetohexokinase/0.444
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.444
3syiFADSulfide-quinone reductase/0.444
4dplNAPMalonyl-CoA reductase1.2.1.750.444
4i7fNVEGag-Pol polyprotein2.7.7.490.444
4isk1JYThymidylate synthase/0.444
4jbiNDPAlcohol dehydrogenase (Zinc)/0.444
4qms1N1Serine/threonine-protein kinase 242.7.11.10.444
4ryvZEAProtein LlR18A/0.444
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.444
5kl9COAAcyl-CoA thioester hydrolase YbgC3.1.20.444
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.443
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.443
1iepSTITyrosine-protein kinase ABL12.7.10.20.443
1uzwCDHIsopenicillin N synthase1.21.3.10.443
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2bu9HFVIsopenicillin N synthase1.21.3.10.443
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.443
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.443
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2nniMTKCytochrome P450 2C8/0.443
2q61SF1Peroxisome proliferator-activated receptor gamma/0.443
2y37A54Nitric oxide synthase, inducible1.14.13.390.443
3bgbLJGGag-Pol polyprotein3.4.23.160.443
3bgxMEFThymidylate synthase/0.443
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3f63GTXGlutathione transferase GST1-4/0.443
3fcjFADNitroalkane oxidase1.7.3.10.443
3hub469Mitogen-activated protein kinase 14/0.443
3o26NDPSalutaridine reductase/0.443
3zep1NXTyrosine-protein kinase JAK32.7.10.20.443
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.443
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4jq8KJ8Epidermal growth factor receptor2.7.10.10.443
4jx1CAHCamphor 5-monooxygenase1.14.15.10.443
4mleVO1Glucokinase2.7.1.20.443
4njvRITProtease/0.443
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
5dp2NAPCurF/0.443
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1h2bNAJNAD-dependent alcohol dehydrogenase/0.442
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.442
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1trgCB3Thymidylate synthase/0.442
2c27ACOMycothiol acetyltransferase2.3.1.1890.442
2itxANPEpidermal growth factor receptor2.7.10.10.442
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
2p5nNDPAldo-keto reductase family 1 member C211.1.10.442
2p5uNADUDP-glucose 4-epimerase/0.442
2qi7MZ9Gag-Pol polyprotein/0.442
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
3hp552PMitogen-activated protein kinase 14/0.442
3kb6NADD-lactate dehydrogenase/0.442
3mdvCL6Cholesterol 24-hydroxylase/0.442
3ms421NGlycogen phosphorylase, muscle form2.4.1.10.442
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.442
3ut5LOCTubulin beta chain/0.442
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.442
4e0iFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.442
4gk4L90Ephrin type-A receptor 32.7.10.10.442
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4mokFADPyranose 2-oxidase/0.442
4nxwADPMitochondrial dynamics protein MID51/0.442
4xgiNADGlutamate dehydrogenase/0.442
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5e8wSTUTGF-beta receptor type-12.7.11.300.442
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.442
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
1di8DTQCyclin-dependent kinase 22.7.11.220.441
1ju6LYAThymidylate synthase2.1.1.450.441
1phhFADp-hydroxybenzoate hydroxylase/0.441
1prcUQ1Reaction center protein L chain/0.441
1rj6AZMCarbonic anhydrase 144.2.1.10.441
1yqy915Lethal factor3.4.24.830.441
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.441
2dbzNAPGlyoxylate reductase1.1.1.260.441
2iviACWIsopenicillin N synthase1.21.3.10.441
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.441
3atzFMNProstaglandin F2a synthase/0.441
3drcMTXDihydrofolate reductase1.5.1.30.441
3ggpNADPrephenate dehydrogenase/0.441
3ih0ANPUncharacterized sugar kinase PH14592.7.10.441
3mg3ECHOrange carotenoid-binding protein/0.441
3opdHIEHeat shock protein 83/0.441
3oqfS51Renin3.4.23.150.441
3p19NDPPutative blue fluorescent protein/0.441
3q5kD1UHeat shock protein 83-1/0.441
3q92XNBKetohexokinase/0.441
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.441
3s55NADPutative short-chain dehydrogenase/reductase/0.441
3tvuB37Acetyl-CoA carboxylase/0.441
3w0aDS5Vitamin D3 receptor/0.441
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4an4DUDPutative glycosyl transferase/0.441
4bb3KKAIsopenicillin N synthase1.21.3.10.441
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.441
4dfrMTXDihydrofolate reductase1.5.1.30.441
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.441
4ji91M3Tyrosine-protein kinase JAK2/0.441
4q71FADBifunctional protein PutA/0.441
4qmzB49Serine/threonine-protein kinase 242.7.11.10.441
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
5idwNAPShort-chain dehydrogenase/reductase SDR/0.441
1b15NAEAlcohol dehydrogenase1.1.1.10.440
1b16NAQAlcohol dehydrogenase1.1.1.10.440
1bwsNDPGDP-L-fucose synthase/0.440
1culFOKAdenylate cyclase type 2/0.440
1culFOKAdenylate cyclase type 5/0.440
1f8fNADBenzyl alcohol dehydrogenase/0.440
1g6kNADGlucose 1-dehydrogenase1.1.1.470.440
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.440
1nboNADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.440
1y0s331Peroxisome proliferator-activated receptor delta/0.440
2bb9AKCGag-Pol polyprotein3.4.23.160.440
2btsU32Cyclin-dependent kinase 22.7.11.220.440
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.440
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.440
2y6o1N1Ephrin type-A receptor 42.7.10.10.440
2ya3J7V5'-AMP-activated protein kinase subunit gamma-1/0.440
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.440
3ajrNADNDP-sugar epimerase/0.440
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3cgeNDPCoenzyme A disulfide reductase/0.440
3clyACPFibroblast growth factor receptor 2/0.440
3cvyFADRE11660p/0.440
3dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3dj4UD1Bifunctional protein GlmU/0.440
3ggoNAIPrephenate dehydrogenase/0.440
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.440
3o9aK14Pol polyprotein/0.440
3qls55VDihydrofolate reductase1.5.1.30.440
3t1tGDPProbable gliding protein mglA/0.440
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.440
3vt9YI4Vitamin D3 receptor/0.440
3wy0COAUncharacterized protein/0.440
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4ejmNAPPutative zinc-binding dehydrogenase/0.440
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4xj43ATCyclic GMP-AMP synthase/0.440
4y3zF41Endothiapepsin3.4.23.220.440
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA23.6.30.440
4zirANPEnergy-coupling factor transporter ATP-binding protein EcfA1/0.440