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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r64740Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r64740Cyclin-dependent kinase 22.7.11.221.000
3s2pPMUCyclin-dependent kinase 22.7.11.220.692
1ckpPVBCyclin-dependent kinase 22.7.11.220.630
3qtzX42Cyclin-dependent kinase 22.7.11.220.617
3qxoX65Cyclin-dependent kinase 22.7.11.220.608
1oitHDTCyclin-dependent kinase 22.7.11.220.606
2a0cCK9Cyclin-dependent kinase 22.7.11.220.605
2duv371Cyclin-dependent kinase 22.7.11.220.600
3lfnA27Cyclin-dependent kinase 22.7.11.220.595
2w06FRVCyclin-dependent kinase 22.7.11.220.593
4lyn1YGCyclin-dependent kinase 22.7.11.220.591
3qu0X40Cyclin-dependent kinase 22.7.11.220.589
1ke7LS3Cyclin-dependent kinase 22.7.11.220.588
3roy22ZCyclin-dependent kinase 22.7.11.220.585
3r7yZ04Cyclin-dependent kinase 22.7.11.220.583
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.582
2b52D42Cyclin-dependent kinase 22.7.11.220.581
2c6o4SPCyclin-dependent kinase 22.7.11.220.581
2w05FRTCyclin-dependent kinase 22.7.11.220.581
3r6xX84Cyclin-dependent kinase 22.7.11.220.581
1v1k3FPCyclin-dependent kinase 22.7.11.220.579
3r73X87Cyclin-dependent kinase 22.7.11.220.578
1ke6LS2Cyclin-dependent kinase 22.7.11.220.576
3r8lZ30Cyclin-dependent kinase 22.7.11.220.576
3qwjX6ACyclin-dependent kinase 22.7.11.220.575
3sqq99ZCyclin-dependent kinase 22.7.11.220.572
4fkr45KCyclin-dependent kinase 22.7.11.220.572
1oguST8Cyclin-dependent kinase 22.7.11.220.571
3r1sX73Cyclin-dependent kinase 22.7.11.220.570
3rmf20ZCyclin-dependent kinase 22.7.11.220.570
3ti1B49Cyclin-dependent kinase 22.7.11.220.569
3r7vZ02Cyclin-dependent kinase 22.7.11.220.568
3r83Z14Cyclin-dependent kinase 22.7.11.220.568
3qqkX02Cyclin-dependent kinase 22.7.11.220.567
3r71X86Cyclin-dependent kinase 22.7.11.220.567
3r9dX6BCyclin-dependent kinase 22.7.11.220.567
4ek816KCyclin-dependent kinase 22.7.11.220.567
3ddpRC8Cyclin-dependent kinase 22.7.11.220.565
3lfqA28Cyclin-dependent kinase 22.7.11.220.565
3qzhX69Cyclin-dependent kinase 22.7.11.220.565
3ezvEZVCyclin-dependent kinase 22.7.11.220.564
3r8vZ62Cyclin-dependent kinase 22.7.11.220.562
4fkq42KCyclin-dependent kinase 22.7.11.220.562
3qwkX62Cyclin-dependent kinase 22.7.11.220.561
1pxmCK5Cyclin-dependent kinase 22.7.11.220.560
2r3lSCWCyclin-dependent kinase 22.7.11.220.560
3rm719ZCyclin-dependent kinase 22.7.11.220.560
1di8DTQCyclin-dependent kinase 22.7.11.220.558
3qqfX07Cyclin-dependent kinase 22.7.11.220.558
3rjc06ZCyclin-dependent kinase 22.7.11.220.556
1h0w207Cyclin-dependent kinase 22.7.11.220.554
4fkv61KCyclin-dependent kinase 22.7.11.220.553
3r1qX75Cyclin-dependent kinase 22.7.11.220.551
3ral04ZCyclin-dependent kinase 22.7.11.220.551
1h1r6CPCyclin-dependent kinase 22.7.11.220.550
2uznC96Cyclin-dependent kinase 22.7.11.220.550
1oi9N20Cyclin-dependent kinase 22.7.11.220.549
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.549
3s1h56ZCyclin-dependent kinase 22.7.11.220.549
3iggEFQCyclin-dependent kinase 22.7.11.220.548
3rk708ZCyclin-dependent kinase 22.7.11.220.548
2r3iSCFCyclin-dependent kinase 22.7.11.220.547
3ezrEZRCyclin-dependent kinase 22.7.11.220.547
3r28XA0Cyclin-dependent kinase 22.7.11.220.547
3rni21ZCyclin-dependent kinase 22.7.11.220.547
3rpo24ZCyclin-dependent kinase 22.7.11.220.547
4erwSTUCyclin-dependent kinase 22.7.11.220.547
1gih1PUCyclin-dependent kinase 22.7.11.220.546
1g5sI17Cyclin-dependent kinase 22.7.11.220.545
2iw94SPCyclin-dependent kinase 22.7.11.220.545
3rpv26ZCyclin-dependent kinase 22.7.11.220.545
4acm7YGCyclin-dependent kinase 22.7.11.220.545
3r7uX96Cyclin-dependent kinase 22.7.11.220.544
3qzgX67Cyclin-dependent kinase 22.7.11.220.543
1h1s4SPCyclin-dependent kinase 22.7.11.220.541
2b55D31Cyclin-dependent kinase 22.7.11.220.541
3rak03ZCyclin-dependent kinase 22.7.11.220.541
3rk909ZCyclin-dependent kinase 22.7.11.220.540
3rm618ZCyclin-dependent kinase 22.7.11.220.540
4bcpT3CCyclin-dependent kinase 22.7.11.220.540
1fvt106Cyclin-dependent kinase 22.7.11.220.538
1ke9LS5Cyclin-dependent kinase 22.7.11.220.538
1unlRRCCyclin-dependent-like kinase 52.7.11.10.537
3pj8404Cyclin-dependent kinase 22.7.11.220.537
2r3p3SCCyclin-dependent kinase 22.7.11.220.533
2uzoC62Cyclin-dependent kinase 22.7.11.220.533
1oiqHDUCyclin-dependent kinase 22.7.11.220.532
1oirHDYCyclin-dependent kinase 22.7.11.220.532
1oiyN41Cyclin-dependent kinase 22.7.11.220.532
1pxlCK4Cyclin-dependent kinase 22.7.11.220.532
1w0xOLOCyclin-dependent kinase 22.7.11.220.530
1ke5LS1Cyclin-dependent kinase 22.7.11.220.529
4fkpLS5Cyclin-dependent kinase 22.7.11.220.529
2a4lRRCCyclin-dependent kinase 22.7.11.220.528
2xmyCDKCyclin-dependent kinase 22.7.11.220.528
1p2a5BNCyclin-dependent kinase 22.7.11.220.527
2btsU32Cyclin-dependent kinase 22.7.11.220.527
2j9mPY8Cyclin-dependent kinase 22.7.11.220.527
4bgh3I6Cyclin-dependent kinase 22.7.11.220.526
1pxpCK8Cyclin-dependent kinase 22.7.11.220.525
1vyw292Cyclin-dependent kinase 22.7.11.220.525
2c6kDT2Cyclin-dependent kinase 22.7.11.220.525
3s0o50ZCyclin-dependent kinase 22.7.11.220.525
3ddqRRCCyclin-dependent kinase 22.7.11.220.524
1y91CT9Cyclin-dependent kinase 22.7.11.220.523
2iw84SPCyclin-dependent kinase 22.7.11.220.523
4eor4SPCyclin-dependent kinase 22.7.11.220.523
1urwI1PCyclin-dependent kinase 22.7.11.220.522
2btrU73Cyclin-dependent kinase 22.7.11.220.520
2r3kSCQCyclin-dependent kinase 22.7.11.220.520
3le62BZCyclin-dependent kinase 22.7.11.220.520
3r7iX9ICyclin-dependent kinase 22.7.11.220.520
1vyzN5BCyclin-dependent kinase 22.7.11.220.519
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.518
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.518
4fko20KCyclin-dependent kinase 22.7.11.220.518
3r9oZ71Cyclin-dependent kinase 22.7.11.220.517
1ykr628Cyclin-dependent kinase 22.7.11.220.516
3qx2X63Cyclin-dependent kinase 22.7.11.220.516
3r1yX76Cyclin-dependent kinase 22.7.11.220.516
3sw418KCyclin-dependent kinase 22.7.11.220.516
3unk0BYCyclin-dependent kinase 22.7.11.220.516
2vv9IM9Cyclin-dependent kinase 22.7.11.220.515
4fks46KCyclin-dependent kinase 22.7.11.220.515
3raiX85Cyclin-dependent kinase 22.7.11.220.514
2r3jSCJCyclin-dependent kinase 22.7.11.220.513
3qtuX44Cyclin-dependent kinase 22.7.11.220.513
1aq1STUCyclin-dependent kinase 22.7.11.220.512
1w8cN69Cyclin-dependent kinase 22.7.11.220.512
2exmZIPCyclin-dependent kinase 22.7.11.220.512
2w17I19Cyclin-dependent kinase 22.7.11.220.512
3lfsA07Cyclin-dependent kinase 22.7.11.220.512
3qxpX64Cyclin-dependent kinase 22.7.11.220.512
3r7eX88Cyclin-dependent kinase 22.7.11.220.512
3r8pZ46Cyclin-dependent kinase 22.7.11.220.512
4ez30S0Cyclin-dependent kinase 22.7.11.220.512
1pxkCK3Cyclin-dependent kinase 22.7.11.220.511
3unj0BXCyclin-dependent kinase 22.7.11.220.511
1gii1PUCyclin-dependent kinase 22.7.11.220.510
1hckATPCyclin-dependent kinase 22.7.11.220.510
2b53D23Cyclin-dependent kinase 22.7.11.220.510
1v0pPVBCell division control protein 2 homolog2.7.11.220.509
2vu3LZECyclin-dependent kinase 22.7.11.220.509
2w1hL0FCyclin-dependent kinase 22.7.11.220.509
2r3gSC9Cyclin-dependent kinase 22.7.11.220.508
3r9hZ67Cyclin-dependent kinase 22.7.11.220.508
1ke8LS4Cyclin-dependent kinase 22.7.11.220.507
2bhhRYUCyclin-dependent kinase 22.7.11.220.507
3qqhX0ACyclin-dependent kinase 22.7.11.220.506
1e1xNW1Cyclin-dependent kinase 22.7.11.220.505
3qtxX43Cyclin-dependent kinase 22.7.11.220.504
3rk507ZCyclin-dependent kinase 22.7.11.220.504
4fkt48KCyclin-dependent kinase 22.7.11.220.504
3qruX19Cyclin-dependent kinase 22.7.11.220.503
4kd11QKCyclin-dependent kinase 22.7.11.220.503
2vtsLZCCyclin-dependent kinase 22.7.11.220.502
3qqlX03Cyclin-dependent kinase 22.7.11.220.502
4eok4SPCyclin-dependent kinase 22.7.11.220.502
4fkw62KCyclin-dependent kinase 22.7.11.220.502
3sw719KCyclin-dependent kinase 22.7.11.220.501
2c6iDT1Cyclin-dependent kinase 22.7.11.220.500
2fvdLIACyclin-dependent kinase 22.7.11.220.500
3py0SU9Cyclin-dependent kinase 22.7.11.220.500
4fki09KCyclin-dependent kinase 22.7.11.220.499
1h1q2A6Cyclin-dependent kinase 22.7.11.220.497
3qrtX14Cyclin-dependent kinase 22.7.11.220.497
4bcoT6QCyclin-dependent kinase 22.7.11.220.497
1dm2HMDCyclin-dependent kinase 22.7.11.220.496
1pxoCK7Cyclin-dependent kinase 22.7.11.220.495
1r78FMDCyclin-dependent kinase 22.7.11.220.495
2c5nCK8Cyclin-dependent kinase 22.7.11.220.495
2r3mSCXCyclin-dependent kinase 22.7.11.220.495
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.495
4cfnJYMCyclin-dependent kinase 22.7.11.220.494
2c6tDT5Cyclin-dependent kinase 22.7.11.220.493
1pyePM1Cyclin-dependent kinase 22.7.11.220.492
3ig7EFPCyclin-dependent kinase 22.7.11.220.492
3rpy27ZCyclin-dependent kinase 22.7.11.220.492
4ek610KCyclin-dependent kinase 22.7.11.220.492
2vthLZ2Cyclin-dependent kinase 22.7.11.220.491
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.489
2x1nX1NCyclin-dependent kinase 22.7.11.220.489
3rkb12ZCyclin-dependent kinase 22.7.11.220.489
1e9hINRCyclin-dependent kinase 22.7.11.220.487
2r3o2SCCyclin-dependent kinase 22.7.11.220.487
3qx4X4BCyclin-dependent kinase 22.7.11.220.487
1h0vUN4Cyclin-dependent kinase 22.7.11.220.486
2c6lDT4Cyclin-dependent kinase 22.7.11.220.486
2wpa889Cyclin-dependent kinase 22.7.11.220.486
3rahO1ZCyclin-dependent kinase 22.7.11.220.485
4fx360KCyclin-dependent kinase 22.7.11.220.485
4fkj11KCyclin-dependent kinase 22.7.11.220.484
1b39ATPCyclin-dependent kinase 22.7.11.220.482
2r3r6SCCyclin-dependent kinase 22.7.11.220.482
3qziX72Cyclin-dependent kinase 22.7.11.220.482
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.481
4bcmT7ZCyclin-dependent kinase 22.7.11.220.481
3nynSGVG protein-coupled receptor kinase 62.7.11.160.480
3uli1N3Cyclin-dependent kinase 22.7.11.220.480
4eon1ROCyclin-dependent kinase 22.7.11.220.479
3ql8X01Cyclin-dependent kinase 22.7.11.220.478
3r8uZ31Cyclin-dependent kinase 22.7.11.220.478
2c6mDT5Cyclin-dependent kinase 22.7.11.220.476
3nup3NUCyclin-dependent kinase 62.7.11.220.476
2vtqLZACyclin-dependent kinase 22.7.11.220.475
3fz1B98Cyclin-dependent kinase 22.7.11.220.475
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.475
2b54D05Cyclin-dependent kinase 22.7.11.220.474
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.474
2uzeC95Cyclin-dependent kinase 22.7.11.220.473
1oiuN76Cyclin-dependent kinase 22.7.11.220.472
2bheBRYCyclin-dependent kinase 22.7.11.220.472
2i40BLZCyclin-dependent kinase 22.7.11.220.472
3sheI85MAP kinase-activated protein kinase 32.7.11.10.472
4eoi1ROCyclin-dependent kinase 22.7.11.220.472
1gij2PUCyclin-dependent kinase 22.7.11.220.471
3qtrX36Cyclin-dependent kinase 22.7.11.220.471
1b38ATPCyclin-dependent kinase 22.7.11.220.470
4fklCK2Cyclin-dependent kinase 22.7.11.220.469
2vtrLZBCyclin-dependent kinase 22.7.11.220.468
3nux3NVCyclin-dependent kinase 62.7.11.220.467
2c5yMTWCyclin-dependent kinase 22.7.11.220.466
2ds11CDCyclin-dependent kinase 22.7.11.220.466
3dogNNNCyclin-dependent kinase 22.7.11.220.466
3qqgX06Cyclin-dependent kinase 22.7.11.220.466
3s00Z60Cyclin-dependent kinase 22.7.11.220.466
4bcnT9NCyclin-dependent kinase 22.7.11.220.466
1y8yCT7Cyclin-dependent kinase 22.7.11.220.465
2wotZZGTGF-beta receptor type-12.7.11.300.465
4eol1ROCyclin-dependent kinase 22.7.11.220.465
4fkg4CKCyclin-dependent kinase 22.7.11.220.465
3r8zZ63Cyclin-dependent kinase 22.7.11.220.464
2uzbC75Cyclin-dependent kinase 22.7.11.220.463
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.462
3qzfX66Cyclin-dependent kinase 22.7.11.220.462
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.461
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.460
2bkzSBCCyclin-dependent kinase 22.7.11.220.459
2eufLQQCyclin-dependent kinase 62.7.11.220.459
1pxjCK2Cyclin-dependent kinase 22.7.11.220.457
2uzlC94Cyclin-dependent kinase 22.7.11.220.457
3r9nZ68Cyclin-dependent kinase 22.7.11.220.457
2pvnP63Casein kinase II subunit alpha2.7.11.10.456
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.456
3my5RFZCyclin-dependent kinase 22.7.11.220.455
4bcqTJFCyclin-dependent kinase 22.7.11.220.454
1eh4IC1Casein kinase I homolog 12.7.11.10.453
3wblPDYCyclin-dependent kinase 22.7.11.220.453
1fvv107Cyclin-dependent kinase 22.7.11.220.451
3rzb02ZCyclin-dependent kinase 22.7.11.220.451
2pvlP55Casein kinase II subunit alpha2.7.11.10.450
1xjdSTUProtein kinase C theta type2.7.11.130.449
2c4g514Cyclin-dependent kinase 22.7.11.220.449
3pxyJWSCyclin-dependent kinase 22.7.11.220.449
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.447
2vttLZDCyclin-dependent kinase 22.7.11.220.446
2c69CT8Cyclin-dependent kinase 22.7.11.220.445
4fob0USALK tyrosine kinase receptor2.7.10.10.445
3mtfA3FActivin receptor type-12.7.11.300.444
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
1h1pCMGCyclin-dependent kinase 22.7.11.220.443
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.442
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.442
2wxvWXVCyclin-dependent kinase 22.7.11.220.441
3tiz3TICyclin-dependent kinase 22.7.11.220.441
4hge15VTyrosine-protein kinase JAK2/0.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.440
2pvhP19Casein kinase II subunit alpha2.7.11.10.440
4ez50RSCyclin-dependent kinase 62.7.11.220.440