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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r3lSCWCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r3lSCWCyclin-dependent kinase 22.7.11.221.000
4acm7YGCyclin-dependent kinase 22.7.11.220.696
2uznC96Cyclin-dependent kinase 22.7.11.220.689
2r3kSCQCyclin-dependent kinase 22.7.11.220.667
3s1h56ZCyclin-dependent kinase 22.7.11.220.657
2r3jSCJCyclin-dependent kinase 22.7.11.220.656
4fks46KCyclin-dependent kinase 22.7.11.220.653
3rak03ZCyclin-dependent kinase 22.7.11.220.639
2w06FRVCyclin-dependent kinase 22.7.11.220.632
1gih1PUCyclin-dependent kinase 22.7.11.220.628
3rpv26ZCyclin-dependent kinase 22.7.11.220.623
3sw418KCyclin-dependent kinase 22.7.11.220.621
1pxmCK5Cyclin-dependent kinase 22.7.11.220.619
3rjc06ZCyclin-dependent kinase 22.7.11.220.619
1fvt106Cyclin-dependent kinase 22.7.11.220.615
2r3p3SCCyclin-dependent kinase 22.7.11.220.614
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.613
2c6iDT1Cyclin-dependent kinase 22.7.11.220.610
3lfnA27Cyclin-dependent kinase 22.7.11.220.609
3ezvEZVCyclin-dependent kinase 22.7.11.220.607
1y91CT9Cyclin-dependent kinase 22.7.11.220.606
3lfqA28Cyclin-dependent kinase 22.7.11.220.606
2c6o4SPCyclin-dependent kinase 22.7.11.220.605
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.605
3ral04ZCyclin-dependent kinase 22.7.11.220.605
1v1k3FPCyclin-dependent kinase 22.7.11.220.603
3rni21ZCyclin-dependent kinase 22.7.11.220.599
2r3mSCXCyclin-dependent kinase 22.7.11.220.598
2uzoC62Cyclin-dependent kinase 22.7.11.220.594
4bgh3I6Cyclin-dependent kinase 22.7.11.220.594
3r9dX6BCyclin-dependent kinase 22.7.11.220.593
4fkv61KCyclin-dependent kinase 22.7.11.220.592
2xmyCDKCyclin-dependent kinase 22.7.11.220.591
1oitHDTCyclin-dependent kinase 22.7.11.220.590
3qtxX43Cyclin-dependent kinase 22.7.11.220.590
1ke7LS3Cyclin-dependent kinase 22.7.11.220.589
2w1hL0FCyclin-dependent kinase 22.7.11.220.589
2r3iSCFCyclin-dependent kinase 22.7.11.220.588
2b52D42Cyclin-dependent kinase 22.7.11.220.587
1ke6LS2Cyclin-dependent kinase 22.7.11.220.586
3r8lZ30Cyclin-dependent kinase 22.7.11.220.583
3s2pPMUCyclin-dependent kinase 22.7.11.220.582
1gii1PUCyclin-dependent kinase 22.7.11.220.579
3sw719KCyclin-dependent kinase 22.7.11.220.579
4fkr45KCyclin-dependent kinase 22.7.11.220.579
1pxkCK3Cyclin-dependent kinase 22.7.11.220.578
1w0xOLOCyclin-dependent kinase 22.7.11.220.577
4ek816KCyclin-dependent kinase 22.7.11.220.577
4fkq42KCyclin-dependent kinase 22.7.11.220.577
1p2a5BNCyclin-dependent kinase 22.7.11.220.576
2vv9IM9Cyclin-dependent kinase 22.7.11.220.576
2w17I19Cyclin-dependent kinase 22.7.11.220.576
3r7uX96Cyclin-dependent kinase 22.7.11.220.574
3rk708ZCyclin-dependent kinase 22.7.11.220.574
3rk507ZCyclin-dependent kinase 22.7.11.220.573
3fz1B98Cyclin-dependent kinase 22.7.11.220.572
3qxoX65Cyclin-dependent kinase 22.7.11.220.570
3iggEFQCyclin-dependent kinase 22.7.11.220.569
3rmf20ZCyclin-dependent kinase 22.7.11.220.569
4fkw62KCyclin-dependent kinase 22.7.11.220.569
2r64740Cyclin-dependent kinase 22.7.11.220.567
2vthLZ2Cyclin-dependent kinase 22.7.11.220.567
3qzhX69Cyclin-dependent kinase 22.7.11.220.567
1oguST8Cyclin-dependent kinase 22.7.11.220.565
3qtzX42Cyclin-dependent kinase 22.7.11.220.565
3rm719ZCyclin-dependent kinase 22.7.11.220.565
2duv371Cyclin-dependent kinase 22.7.11.220.564
2a0cCK9Cyclin-dependent kinase 22.7.11.220.563
3pj8404Cyclin-dependent kinase 22.7.11.220.563
3rk909ZCyclin-dependent kinase 22.7.11.220.563
3qqhX0ACyclin-dependent kinase 22.7.11.220.562
4fko20KCyclin-dependent kinase 22.7.11.220.561
1pxpCK8Cyclin-dependent kinase 22.7.11.220.560
3qzgX67Cyclin-dependent kinase 22.7.11.220.560
3wblPDYCyclin-dependent kinase 22.7.11.220.560
2b53D23Cyclin-dependent kinase 22.7.11.220.559
1g5sI17Cyclin-dependent kinase 22.7.11.220.557
1urwI1PCyclin-dependent kinase 22.7.11.220.557
3qtuX44Cyclin-dependent kinase 22.7.11.220.557
3ti1B49Cyclin-dependent kinase 22.7.11.220.556
4fkj11KCyclin-dependent kinase 22.7.11.220.556
2a4lRRCCyclin-dependent kinase 22.7.11.220.553
1ykr628Cyclin-dependent kinase 22.7.11.220.552
3uli1N3Cyclin-dependent kinase 22.7.11.220.552
2btrU73Cyclin-dependent kinase 22.7.11.220.550
3qxpX64Cyclin-dependent kinase 22.7.11.220.550
4fkt48KCyclin-dependent kinase 22.7.11.220.550
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.549
2vttLZDCyclin-dependent kinase 22.7.11.220.549
3rkb12ZCyclin-dependent kinase 22.7.11.220.549
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.548
3ig7EFPCyclin-dependent kinase 22.7.11.220.547
3r7iX9ICyclin-dependent kinase 22.7.11.220.547
3rm618ZCyclin-dependent kinase 22.7.11.220.547
3sqq99ZCyclin-dependent kinase 22.7.11.220.546
1h1s4SPCyclin-dependent kinase 22.7.11.220.545
2c6lDT4Cyclin-dependent kinase 22.7.11.220.544
1pxlCK4Cyclin-dependent kinase 22.7.11.220.543
3le62BZCyclin-dependent kinase 22.7.11.220.542
3r7vZ02Cyclin-dependent kinase 22.7.11.220.541
3r7yZ04Cyclin-dependent kinase 22.7.11.220.541
1pyePM1Cyclin-dependent kinase 22.7.11.220.540
2b55D31Cyclin-dependent kinase 22.7.11.220.540
2bheBRYCyclin-dependent kinase 22.7.11.220.540
3roy22ZCyclin-dependent kinase 22.7.11.220.540
2j9mPY8Cyclin-dependent kinase 22.7.11.220.539
2vtsLZCCyclin-dependent kinase 22.7.11.220.539
3qtrX36Cyclin-dependent kinase 22.7.11.220.538
1pxoCK7Cyclin-dependent kinase 22.7.11.220.537
3qu0X40Cyclin-dependent kinase 22.7.11.220.536
4fkpLS5Cyclin-dependent kinase 22.7.11.220.536
1ke5LS1Cyclin-dependent kinase 22.7.11.220.535
1oirHDYCyclin-dependent kinase 22.7.11.220.535
3r73X87Cyclin-dependent kinase 22.7.11.220.535
3r6xX84Cyclin-dependent kinase 22.7.11.220.534
1oiqHDUCyclin-dependent kinase 22.7.11.220.533
3qqlX03Cyclin-dependent kinase 22.7.11.220.533
3r8zZ63Cyclin-dependent kinase 22.7.11.220.533
3r83Z14Cyclin-dependent kinase 22.7.11.220.532
3qqkX02Cyclin-dependent kinase 22.7.11.220.531
1di8DTQCyclin-dependent kinase 22.7.11.220.529
1w8cN69Cyclin-dependent kinase 22.7.11.220.529
2c6kDT2Cyclin-dependent kinase 22.7.11.220.529
3pxyJWSCyclin-dependent kinase 22.7.11.220.529
2iw84SPCyclin-dependent kinase 22.7.11.220.528
3r1sX73Cyclin-dependent kinase 22.7.11.220.528
3r8vZ62Cyclin-dependent kinase 22.7.11.220.528
2r3gSC9Cyclin-dependent kinase 22.7.11.220.527
2w05FRTCyclin-dependent kinase 22.7.11.220.527
2r3q5SCCyclin-dependent kinase 22.7.11.220.526
3r9hZ67Cyclin-dependent kinase 22.7.11.220.526
1ke9LS5Cyclin-dependent kinase 22.7.11.220.525
3raiX85Cyclin-dependent kinase 22.7.11.220.525
4erwSTUCyclin-dependent kinase 22.7.11.220.525
1fvv107Cyclin-dependent kinase 22.7.11.220.524
1h1r6CPCyclin-dependent kinase 22.7.11.220.524
4lyn1YGCyclin-dependent kinase 22.7.11.220.524
3r9oZ71Cyclin-dependent kinase 22.7.11.220.523
4eok4SPCyclin-dependent kinase 22.7.11.220.523
1gij2PUCyclin-dependent kinase 22.7.11.220.522
2c6tDT5Cyclin-dependent kinase 22.7.11.220.522
2iw94SPCyclin-dependent kinase 22.7.11.220.521
3r1qX75Cyclin-dependent kinase 22.7.11.220.521
3rpo24ZCyclin-dependent kinase 22.7.11.220.521
1aq1STUCyclin-dependent kinase 22.7.11.220.520
2r3fSC8Cyclin-dependent kinase 22.7.11.220.519
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.519
3lfsA07Cyclin-dependent kinase 22.7.11.220.519
3qqfX07Cyclin-dependent kinase 22.7.11.220.519
1vyzN5BCyclin-dependent kinase 22.7.11.220.518
2btsU32Cyclin-dependent kinase 22.7.11.220.517
2b54D05Cyclin-dependent kinase 22.7.11.220.515
2vtrLZBCyclin-dependent kinase 22.7.11.220.515
3ddpRC8Cyclin-dependent kinase 22.7.11.220.515
3py0SU9Cyclin-dependent kinase 22.7.11.220.515
3r1yX76Cyclin-dependent kinase 22.7.11.220.515
1ke8LS4Cyclin-dependent kinase 22.7.11.220.514
3ezrEZRCyclin-dependent kinase 22.7.11.220.514
3r8uZ31Cyclin-dependent kinase 22.7.11.220.514
2bhhRYUCyclin-dependent kinase 22.7.11.220.513
2i40BLZCyclin-dependent kinase 22.7.11.220.513
3rzb02ZCyclin-dependent kinase 22.7.11.220.513
4fx360KCyclin-dependent kinase 22.7.11.220.513
3unk0BYCyclin-dependent kinase 22.7.11.220.512
2fvdLIACyclin-dependent kinase 22.7.11.220.511
1oi9N20Cyclin-dependent kinase 22.7.11.220.510
1h0w207Cyclin-dependent kinase 22.7.11.220.508
1oiyN41Cyclin-dependent kinase 22.7.11.220.508
3s0o50ZCyclin-dependent kinase 22.7.11.220.508
1y8yCT7Cyclin-dependent kinase 22.7.11.220.507
3r28XA0Cyclin-dependent kinase 22.7.11.220.507
2x1nX1NCyclin-dependent kinase 22.7.11.220.506
2xnbY8LCyclin-dependent kinase 22.7.11.220.506
4qmpDKISerine/threonine-protein kinase 242.7.11.10.506
3sheI85MAP kinase-activated protein kinase 32.7.11.10.504
2uzdC85Cyclin-dependent kinase 22.7.11.220.503
3qtqX35Cyclin-dependent kinase 22.7.11.220.503
2c6mDT5Cyclin-dependent kinase 22.7.11.220.502
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.502
3qwkX62Cyclin-dependent kinase 22.7.11.220.502
3qruX19Cyclin-dependent kinase 22.7.11.220.501
4ez30S0Cyclin-dependent kinase 22.7.11.220.501
4fki09KCyclin-dependent kinase 22.7.11.220.500
2vu3LZECyclin-dependent kinase 22.7.11.220.499
1pkdUCNCyclin-dependent kinase 22.7.11.220.498
1r78FMDCyclin-dependent kinase 22.7.11.220.498
2r3r6SCCyclin-dependent kinase 22.7.11.220.498
3qwjX6ACyclin-dependent kinase 22.7.11.220.498
4kd11QKCyclin-dependent kinase 22.7.11.220.498
1dm2HMDCyclin-dependent kinase 22.7.11.220.497
3r8pZ46Cyclin-dependent kinase 22.7.11.220.497
2wihP48Cyclin-dependent kinase 22.7.11.220.496
3qrtX14Cyclin-dependent kinase 22.7.11.220.496
3r71X86Cyclin-dependent kinase 22.7.11.220.496
2eufLQQCyclin-dependent kinase 62.7.11.220.495
3ddqRRCCyclin-dependent kinase 22.7.11.220.495
3ggfGVDSerine/threonine-protein kinase 26/0.495
1unlRRCCyclin-dependent-like kinase 52.7.11.10.494
3qzfX66Cyclin-dependent kinase 22.7.11.220.494
3rpy27ZCyclin-dependent kinase 22.7.11.220.494
4bcmT7ZCyclin-dependent kinase 22.7.11.220.494
3s00Z60Cyclin-dependent kinase 22.7.11.220.493
4eor4SPCyclin-dependent kinase 22.7.11.220.491
4bcpT3CCyclin-dependent kinase 22.7.11.220.490
4ek610KCyclin-dependent kinase 22.7.11.220.490
4fklCK2Cyclin-dependent kinase 22.7.11.220.490
3nux3NVCyclin-dependent kinase 62.7.11.220.489
1eh4IC1Casein kinase I homolog 12.7.11.10.487
1vyw292Cyclin-dependent kinase 22.7.11.220.487
2vtqLZACyclin-dependent kinase 22.7.11.220.487
1b39ATPCyclin-dependent kinase 22.7.11.220.486
2pvlP55Casein kinase II subunit alpha2.7.11.10.486
2wxvWXVCyclin-dependent kinase 22.7.11.220.486
3qx2X63Cyclin-dependent kinase 22.7.11.220.484
1oiuN76Cyclin-dependent kinase 22.7.11.220.483
2c5yMTWCyclin-dependent kinase 22.7.11.220.483
2pvnP63Casein kinase II subunit alpha2.7.11.10.483
3r7eX88Cyclin-dependent kinase 22.7.11.220.483
2r3o2SCCyclin-dependent kinase 22.7.11.220.482
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.482
1b38ATPCyclin-dependent kinase 22.7.11.220.480
1finATPCyclin-dependent kinase 22.7.11.220.480
3rahO1ZCyclin-dependent kinase 22.7.11.220.480
3tnwF18Cyclin-dependent kinase 22.7.11.220.480
3my5RFZCyclin-dependent kinase 22.7.11.220.479
1ckpPVBCyclin-dependent kinase 22.7.11.220.478
2uzlC94Cyclin-dependent kinase 22.7.11.220.478
3dogNNNCyclin-dependent kinase 22.7.11.220.478
4eon1ROCyclin-dependent kinase 22.7.11.220.478
2uzbC75Cyclin-dependent kinase 22.7.11.220.477
4bcoT6QCyclin-dependent kinase 22.7.11.220.477
4bcnT9NCyclin-dependent kinase 22.7.11.220.476
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.476
4ivb1J5Tyrosine-protein kinase JAK1/0.476
2uzeC95Cyclin-dependent kinase 22.7.11.220.474
3unj0BXCyclin-dependent kinase 22.7.11.220.472
3qtwX3ACyclin-dependent kinase 22.7.11.220.470
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.470
2c5nCK8Cyclin-dependent kinase 22.7.11.220.469
2wpa889Cyclin-dependent kinase 22.7.11.220.469
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.469
3tiz3TICyclin-dependent kinase 22.7.11.220.469
3lq5SLQCyclin-dependent kinase 92.7.11.220.468
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.467
1e9hINRCyclin-dependent kinase 22.7.11.220.466
1h1q2A6Cyclin-dependent kinase 22.7.11.220.466
2ds11CDCyclin-dependent kinase 22.7.11.220.466
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.466
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.466
4ez50RSCyclin-dependent kinase 62.7.11.220.466
4fkg4CKCyclin-dependent kinase 22.7.11.220.465
5dr6SKEAurora kinase A2.7.11.10.465
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.464
1hckATPCyclin-dependent kinase 22.7.11.220.463
1xjdSTUProtein kinase C theta type2.7.11.130.463
1h0vUN4Cyclin-dependent kinase 22.7.11.220.462
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
2cchATPCyclin-dependent kinase 22.7.11.220.460
3be9P04Casein kinase II subunit alpha2.7.11.10.460
3qziX72Cyclin-dependent kinase 22.7.11.220.460
3r9nZ68Cyclin-dependent kinase 22.7.11.220.459
3qqgX06Cyclin-dependent kinase 22.7.11.220.458
3ql8X01Cyclin-dependent kinase 22.7.11.220.457
4gub0Y4Casein kinase II subunit alpha2.7.11.10.457
4ii5ADPCyclin-dependent kinase 22.7.11.220.457
5dr9SKEAurora kinase A2.7.11.10.457
2c69CT8Cyclin-dependent kinase 22.7.11.220.456
3lltANPProtein serine/threonine kinase-1/0.456
3nynSGVG protein-coupled receptor kinase 62.7.11.160.456
1v0pPVBCell division control protein 2 homolog2.7.11.220.454
2f2cAP9Cyclin-dependent kinase 62.7.11.220.454
3qx4X4BCyclin-dependent kinase 22.7.11.220.454
2chlDKICasein kinase I isoform gamma-32.7.11.10.453
2exmZIPCyclin-dependent kinase 22.7.11.220.453
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.453
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.452
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.452
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.451
3gxlQIGTGF-beta receptor type-12.7.11.300.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
3qtsX46Cyclin-dependent kinase 22.7.11.220.449
4btjATPTau-tubulin kinase 12.7.11.10.449
1om1IQACasein kinase II subunit alpha2.7.11.10.448
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.448
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.448
4eomATPCyclin-dependent kinase 22.7.11.220.448
4j54G52Gag-Pol polyprotein3.4.23.160.448
4ktc1X3Genome polyprotein3.4.21.980.448
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.446
3gubGUBDeath-associated protein kinase 12.7.11.10.446
4aqc88ATyrosine-protein kinase JAK2/0.446
4qgiROCGag-Pol polyprotein3.4.23.160.446
2c4g514Cyclin-dependent kinase 22.7.11.220.445
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4e4m0NHTyrosine-protein kinase JAK2/0.445
5e8wSTUTGF-beta receptor type-12.7.11.300.445
4aua4AUCyclin-dependent kinase 62.7.11.220.444
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.444
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.444
1h1pCMGCyclin-dependent kinase 22.7.11.220.443
2b7aIZATyrosine-protein kinase JAK2/0.443
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.443
5dt0SKEAurora kinase A2.7.11.10.443
1e1xNW1Cyclin-dependent kinase 22.7.11.220.442
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
1m2rMNYCasein kinase II subunit alpha2.7.11.10.441
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.441
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2wipP49Cyclin-dependent kinase 22.7.11.220.441
4i8zG08Gag-Pol polyprotein3.4.23.160.441
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.441
1v0oINRCell division control protein 2 homolog2.7.11.220.440
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.440
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.440
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.440