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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r3kSCQCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r3kSCQCyclin-dependent kinase 22.7.11.221.000
2r3jSCJCyclin-dependent kinase 22.7.11.220.687
2r3lSCWCyclin-dependent kinase 22.7.11.220.660
3iggEFQCyclin-dependent kinase 22.7.11.220.656
2r3p3SCCyclin-dependent kinase 22.7.11.220.631
2r3mSCXCyclin-dependent kinase 22.7.11.220.622
4acm7YGCyclin-dependent kinase 22.7.11.220.609
3s1h56ZCyclin-dependent kinase 22.7.11.220.604
3ig7EFPCyclin-dependent kinase 22.7.11.220.594
2r3fSC8Cyclin-dependent kinase 22.7.11.220.586
2a0cCK9Cyclin-dependent kinase 22.7.11.220.585
3lfnA27Cyclin-dependent kinase 22.7.11.220.584
3rak03ZCyclin-dependent kinase 22.7.11.220.583
1w0xOLOCyclin-dependent kinase 22.7.11.220.580
4fkt48KCyclin-dependent kinase 22.7.11.220.579
3rjc06ZCyclin-dependent kinase 22.7.11.220.577
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.574
3qtrX36Cyclin-dependent kinase 22.7.11.220.572
3r9dX6BCyclin-dependent kinase 22.7.11.220.568
2c6iDT1Cyclin-dependent kinase 22.7.11.220.567
2w06FRVCyclin-dependent kinase 22.7.11.220.567
3qqhX0ACyclin-dependent kinase 22.7.11.220.566
3ral04ZCyclin-dependent kinase 22.7.11.220.565
1p2a5BNCyclin-dependent kinase 22.7.11.220.562
4ek816KCyclin-dependent kinase 22.7.11.220.561
3pj8404Cyclin-dependent kinase 22.7.11.220.560
3lfsA07Cyclin-dependent kinase 22.7.11.220.557
3lfqA28Cyclin-dependent kinase 22.7.11.220.556
3r7yZ04Cyclin-dependent kinase 22.7.11.220.553
3rk708ZCyclin-dependent kinase 22.7.11.220.552
2w1hL0FCyclin-dependent kinase 22.7.11.220.551
3ezvEZVCyclin-dependent kinase 22.7.11.220.549
3qxoX65Cyclin-dependent kinase 22.7.11.220.549
4fks46KCyclin-dependent kinase 22.7.11.220.549
1y91CT9Cyclin-dependent kinase 22.7.11.220.548
4fkr45KCyclin-dependent kinase 22.7.11.220.548
2r3gSC9Cyclin-dependent kinase 22.7.11.220.546
2w17I19Cyclin-dependent kinase 22.7.11.220.546
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.544
3r83Z14Cyclin-dependent kinase 22.7.11.220.544
3rpv26ZCyclin-dependent kinase 22.7.11.220.542
3sw418KCyclin-dependent kinase 22.7.11.220.542
3rni21ZCyclin-dependent kinase 22.7.11.220.541
3qxpX64Cyclin-dependent kinase 22.7.11.220.540
1pxmCK5Cyclin-dependent kinase 22.7.11.220.539
2vv9IM9Cyclin-dependent kinase 22.7.11.220.539
1g5sI17Cyclin-dependent kinase 22.7.11.220.538
2b52D42Cyclin-dependent kinase 22.7.11.220.538
3r7iX9ICyclin-dependent kinase 22.7.11.220.538
2c6o4SPCyclin-dependent kinase 22.7.11.220.537
2uznC96Cyclin-dependent kinase 22.7.11.220.537
2j9mPY8Cyclin-dependent kinase 22.7.11.220.536
2r3o2SCCyclin-dependent kinase 22.7.11.220.536
2r3q5SCCyclin-dependent kinase 22.7.11.220.534
3rm719ZCyclin-dependent kinase 22.7.11.220.533
1fvt106Cyclin-dependent kinase 22.7.11.220.532
1oitHDTCyclin-dependent kinase 22.7.11.220.532
2xmyCDKCyclin-dependent kinase 22.7.11.220.531
3rmf20ZCyclin-dependent kinase 22.7.11.220.531
1v1k3FPCyclin-dependent kinase 22.7.11.220.530
2uzoC62Cyclin-dependent kinase 22.7.11.220.530
3qzgX67Cyclin-dependent kinase 22.7.11.220.530
1gii1PUCyclin-dependent kinase 22.7.11.220.528
2btrU73Cyclin-dependent kinase 22.7.11.220.528
4bgh3I6Cyclin-dependent kinase 22.7.11.220.527
4fkv61KCyclin-dependent kinase 22.7.11.220.527
3ezrEZRCyclin-dependent kinase 22.7.11.220.526
1pxlCK4Cyclin-dependent kinase 22.7.11.220.525
2r3r6SCCyclin-dependent kinase 22.7.11.220.525
2vttLZDCyclin-dependent kinase 22.7.11.220.524
3qtxX43Cyclin-dependent kinase 22.7.11.220.524
3rahO1ZCyclin-dependent kinase 22.7.11.220.524
1gih1PUCyclin-dependent kinase 22.7.11.220.522
3s2pPMUCyclin-dependent kinase 22.7.11.220.522
3sqq99ZCyclin-dependent kinase 22.7.11.220.522
3r7vZ02Cyclin-dependent kinase 22.7.11.220.521
4lyn1YGCyclin-dependent kinase 22.7.11.220.520
2a4lRRCCyclin-dependent kinase 22.7.11.220.519
2r64740Cyclin-dependent kinase 22.7.11.220.519
3qwjX6ACyclin-dependent kinase 22.7.11.220.519
4fkq42KCyclin-dependent kinase 22.7.11.220.519
3r7uX96Cyclin-dependent kinase 22.7.11.220.518
3rm618ZCyclin-dependent kinase 22.7.11.220.517
3qtuX44Cyclin-dependent kinase 22.7.11.220.516
3r6xX84Cyclin-dependent kinase 22.7.11.220.516
4fx360KCyclin-dependent kinase 22.7.11.220.515
3qtwX3ACyclin-dependent kinase 22.7.11.220.514
3r8pZ46Cyclin-dependent kinase 22.7.11.220.514
1pxpCK8Cyclin-dependent kinase 22.7.11.220.513
2w05FRTCyclin-dependent kinase 22.7.11.220.513
3r8lZ30Cyclin-dependent kinase 22.7.11.220.512
3rk507ZCyclin-dependent kinase 22.7.11.220.511
2r3iSCFCyclin-dependent kinase 22.7.11.220.510
3qqkX02Cyclin-dependent kinase 22.7.11.220.509
4fkpLS5Cyclin-dependent kinase 22.7.11.220.509
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.507
3ti1B49Cyclin-dependent kinase 22.7.11.220.507
1urwI1PCyclin-dependent kinase 22.7.11.220.506
2c69CT8Cyclin-dependent kinase 22.7.11.220.505
2b55D31Cyclin-dependent kinase 22.7.11.220.504
3rpo24ZCyclin-dependent kinase 22.7.11.220.504
3qruX19Cyclin-dependent kinase 22.7.11.220.503
3qx2X63Cyclin-dependent kinase 22.7.11.220.502
3r73X87Cyclin-dependent kinase 22.7.11.220.502
1pxoCK7Cyclin-dependent kinase 22.7.11.220.501
3r8zZ63Cyclin-dependent kinase 22.7.11.220.501
3s0o50ZCyclin-dependent kinase 22.7.11.220.501
3wblPDYCyclin-dependent kinase 22.7.11.220.501
2b53D23Cyclin-dependent kinase 22.7.11.220.500
4fki09KCyclin-dependent kinase 22.7.11.220.499
1ke7LS3Cyclin-dependent kinase 22.7.11.220.498
3unk0BYCyclin-dependent kinase 22.7.11.220.498
3qqlX03Cyclin-dependent kinase 22.7.11.220.497
2wpa889Cyclin-dependent kinase 22.7.11.220.496
3rkb12ZCyclin-dependent kinase 22.7.11.220.496
3roy22ZCyclin-dependent kinase 22.7.11.220.496
3tiz3TICyclin-dependent kinase 22.7.11.220.496
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.495
3r1yX76Cyclin-dependent kinase 22.7.11.220.495
4fkj11KCyclin-dependent kinase 22.7.11.220.495
4fko20KCyclin-dependent kinase 22.7.11.220.495
3qzhX69Cyclin-dependent kinase 22.7.11.220.494
3r9hZ67Cyclin-dependent kinase 22.7.11.220.494
1ke6LS2Cyclin-dependent kinase 22.7.11.220.493
1oiqHDUCyclin-dependent kinase 22.7.11.220.492
1w8cN69Cyclin-dependent kinase 22.7.11.220.492
2c6lDT4Cyclin-dependent kinase 22.7.11.220.491
1h1r6CPCyclin-dependent kinase 22.7.11.220.490
2vtsLZCCyclin-dependent kinase 22.7.11.220.490
3sw719KCyclin-dependent kinase 22.7.11.220.490
3pxyJWSCyclin-dependent kinase 22.7.11.220.488
3qqfX07Cyclin-dependent kinase 22.7.11.220.488
3r28XA0Cyclin-dependent kinase 22.7.11.220.488
3raiX85Cyclin-dependent kinase 22.7.11.220.487
1ke9LS5Cyclin-dependent kinase 22.7.11.220.486
1oguST8Cyclin-dependent kinase 22.7.11.220.486
2vthLZ2Cyclin-dependent kinase 22.7.11.220.486
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.486
3r71X86Cyclin-dependent kinase 22.7.11.220.486
3rk909ZCyclin-dependent kinase 22.7.11.220.486
3r8vZ62Cyclin-dependent kinase 22.7.11.220.485
4fkg4CKCyclin-dependent kinase 22.7.11.220.485
4fkw62KCyclin-dependent kinase 22.7.11.220.485
1oiyN41Cyclin-dependent kinase 22.7.11.220.484
3qtzX42Cyclin-dependent kinase 22.7.11.220.484
1ke5LS1Cyclin-dependent kinase 22.7.11.220.483
3fz1B98Cyclin-dependent kinase 22.7.11.220.482
1vyw292Cyclin-dependent kinase 22.7.11.220.481
2iw84SPCyclin-dependent kinase 22.7.11.220.481
2bheBRYCyclin-dependent kinase 22.7.11.220.480
1ckpPVBCyclin-dependent kinase 22.7.11.220.479
3ddqRRCCyclin-dependent kinase 22.7.11.220.479
3qu0X40Cyclin-dependent kinase 22.7.11.220.478
2wxvWXVCyclin-dependent kinase 22.7.11.220.477
3r1sX73Cyclin-dependent kinase 22.7.11.220.477
1pyePM1Cyclin-dependent kinase 22.7.11.220.476
3ddpRC8Cyclin-dependent kinase 22.7.11.220.476
4bcpT3CCyclin-dependent kinase 22.7.11.220.476
3rpy27ZCyclin-dependent kinase 22.7.11.220.474
4erwSTUCyclin-dependent kinase 22.7.11.220.474
3qtqX35Cyclin-dependent kinase 22.7.11.220.471
1dm2HMDCyclin-dependent kinase 22.7.11.220.470
2btsU32Cyclin-dependent kinase 22.7.11.220.470
3r1qX75Cyclin-dependent kinase 22.7.11.220.470
2c6kDT2Cyclin-dependent kinase 22.7.11.220.469
3qtsX46Cyclin-dependent kinase 22.7.11.220.468
3r9nZ68Cyclin-dependent kinase 22.7.11.220.468
4kd11QKCyclin-dependent kinase 22.7.11.220.468
1fvv107Cyclin-dependent kinase 22.7.11.220.467
1ykr628Cyclin-dependent kinase 22.7.11.220.467
1h1q2A6Cyclin-dependent kinase 22.7.11.220.465
1oirHDYCyclin-dependent kinase 22.7.11.220.465
2vtqLZACyclin-dependent kinase 22.7.11.220.465
3qzfX66Cyclin-dependent kinase 22.7.11.220.465
3tnwF18Cyclin-dependent kinase 22.7.11.220.465
2duv371Cyclin-dependent kinase 22.7.11.220.464
1gij2PUCyclin-dependent kinase 22.7.11.220.463
1oi9N20Cyclin-dependent kinase 22.7.11.220.463
2vu3LZECyclin-dependent kinase 22.7.11.220.462
1h1s4SPCyclin-dependent kinase 22.7.11.220.460
2b54D05Cyclin-dependent kinase 22.7.11.220.459
2c6mDT5Cyclin-dependent kinase 22.7.11.220.459
3qziX72Cyclin-dependent kinase 22.7.11.220.459
2i40BLZCyclin-dependent kinase 22.7.11.220.458
2x1nX1NCyclin-dependent kinase 22.7.11.220.458
2c6tDT5Cyclin-dependent kinase 22.7.11.220.457
2fvdLIACyclin-dependent kinase 22.7.11.220.457
3qwkX62Cyclin-dependent kinase 22.7.11.220.457
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.456
1di8DTQCyclin-dependent kinase 22.7.11.220.455
1vyzN5BCyclin-dependent kinase 22.7.11.220.455
2c5yMTWCyclin-dependent kinase 22.7.11.220.455
1oiuN76Cyclin-dependent kinase 22.7.11.220.454
4eok4SPCyclin-dependent kinase 22.7.11.220.454
1b38ATPCyclin-dependent kinase 22.7.11.220.453
1pxkCK3Cyclin-dependent kinase 22.7.11.220.453
3unj0BXCyclin-dependent kinase 22.7.11.220.453
1pkdUCNCyclin-dependent kinase 22.7.11.220.452
3qrtX14Cyclin-dependent kinase 22.7.11.220.452
3ql8X01Cyclin-dependent kinase 22.7.11.220.450
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.450
1ke8LS4Cyclin-dependent kinase 22.7.11.220.449
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
2c68CT6Cyclin-dependent kinase 22.7.11.220.448
3rzb02ZCyclin-dependent kinase 22.7.11.220.448
4bcoT6QCyclin-dependent kinase 22.7.11.220.448
2wihP48Cyclin-dependent kinase 22.7.11.220.447
3dogNNNCyclin-dependent kinase 22.7.11.220.447
4qmpDKISerine/threonine-protein kinase 242.7.11.10.447
5dt0SKEAurora kinase A2.7.11.10.447
1unlRRCCyclin-dependent-like kinase 52.7.11.10.446
4eor4SPCyclin-dependent kinase 22.7.11.220.446
2vtrLZBCyclin-dependent kinase 22.7.11.220.445
3r9oZ71Cyclin-dependent kinase 22.7.11.220.445
1e9hINRCyclin-dependent kinase 22.7.11.220.444
3r8uZ31Cyclin-dependent kinase 22.7.11.220.444
4ek610KCyclin-dependent kinase 22.7.11.220.444
2eufLQQCyclin-dependent kinase 62.7.11.220.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
2uzdC85Cyclin-dependent kinase 22.7.11.220.442
4qmySTUSerine/threonine-protein kinase 242.7.11.10.442
3py0SU9Cyclin-dependent kinase 22.7.11.220.441
3s00Z60Cyclin-dependent kinase 22.7.11.220.441
4ez30S0Cyclin-dependent kinase 22.7.11.220.441
5dpvSKEAurora kinase A2.7.11.10.441