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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r3gSC9Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r3gSC9Cyclin-dependent kinase 22.7.11.221.000
2r3fSC8Cyclin-dependent kinase 22.7.11.220.648
2r3iSCFCyclin-dependent kinase 22.7.11.220.634
2r3r6SCCyclin-dependent kinase 22.7.11.220.618
1w8cN69Cyclin-dependent kinase 22.7.11.220.590
3qx2X63Cyclin-dependent kinase 22.7.11.220.581
3r7yZ04Cyclin-dependent kinase 22.7.11.220.578
3rahO1ZCyclin-dependent kinase 22.7.11.220.569
3r83Z14Cyclin-dependent kinase 22.7.11.220.568
2c6mDT5Cyclin-dependent kinase 22.7.11.220.566
2r3o2SCCyclin-dependent kinase 22.7.11.220.564
2a4lRRCCyclin-dependent kinase 22.7.11.220.555
2c69CT8Cyclin-dependent kinase 22.7.11.220.555
2c6iDT1Cyclin-dependent kinase 22.7.11.220.553
2r3p3SCCyclin-dependent kinase 22.7.11.220.552
3lfnA27Cyclin-dependent kinase 22.7.11.220.552
1h0vUN4Cyclin-dependent kinase 22.7.11.220.551
3raiX85Cyclin-dependent kinase 22.7.11.220.551
2w05FRTCyclin-dependent kinase 22.7.11.220.550
2b54D05Cyclin-dependent kinase 22.7.11.220.547
3qzgX67Cyclin-dependent kinase 22.7.11.220.547
2j9mPY8Cyclin-dependent kinase 22.7.11.220.546
1h0w207Cyclin-dependent kinase 22.7.11.220.545
4fkt48KCyclin-dependent kinase 22.7.11.220.545
4fkr45KCyclin-dependent kinase 22.7.11.220.543
2r3q5SCCyclin-dependent kinase 22.7.11.220.542
2r3kSCQCyclin-dependent kinase 22.7.11.220.541
3qziX72Cyclin-dependent kinase 22.7.11.220.541
3lfqA28Cyclin-dependent kinase 22.7.11.220.540
2vtsLZCCyclin-dependent kinase 22.7.11.220.539
3r8vZ62Cyclin-dependent kinase 22.7.11.220.539
3rm719ZCyclin-dependent kinase 22.7.11.220.538
2r64740Cyclin-dependent kinase 22.7.11.220.537
3qwjX6ACyclin-dependent kinase 22.7.11.220.537
3r8uZ31Cyclin-dependent kinase 22.7.11.220.536
2c6o4SPCyclin-dependent kinase 22.7.11.220.535
3r71X86Cyclin-dependent kinase 22.7.11.220.535
3rm618ZCyclin-dependent kinase 22.7.11.220.535
3roy22ZCyclin-dependent kinase 22.7.11.220.534
4fkj11KCyclin-dependent kinase 22.7.11.220.533
1e1xNW1Cyclin-dependent kinase 22.7.11.220.531
1w0xOLOCyclin-dependent kinase 22.7.11.220.531
2r3lSCWCyclin-dependent kinase 22.7.11.220.531
2fvdLIACyclin-dependent kinase 22.7.11.220.530
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.529
3qqlX03Cyclin-dependent kinase 22.7.11.220.529
2c68CT6Cyclin-dependent kinase 22.7.11.220.527
2iw84SPCyclin-dependent kinase 22.7.11.220.527
3qqhX0ACyclin-dependent kinase 22.7.11.220.527
1oitHDTCyclin-dependent kinase 22.7.11.220.524
2a0cCK9Cyclin-dependent kinase 22.7.11.220.524
3r28XA0Cyclin-dependent kinase 22.7.11.220.524
3rak03ZCyclin-dependent kinase 22.7.11.220.523
1h1r6CPCyclin-dependent kinase 22.7.11.220.521
3r7vZ02Cyclin-dependent kinase 22.7.11.220.521
4fklCK2Cyclin-dependent kinase 22.7.11.220.520
2uznC96Cyclin-dependent kinase 22.7.11.220.519
3r1yX76Cyclin-dependent kinase 22.7.11.220.519
3ddqRRCCyclin-dependent kinase 22.7.11.220.518
3s1h56ZCyclin-dependent kinase 22.7.11.220.517
3qtuX44Cyclin-dependent kinase 22.7.11.220.516
3rpo24ZCyclin-dependent kinase 22.7.11.220.516
3s2pPMUCyclin-dependent kinase 22.7.11.220.516
3qtzX42Cyclin-dependent kinase 22.7.11.220.515
2b52D42Cyclin-dependent kinase 22.7.11.220.514
3rk708ZCyclin-dependent kinase 22.7.11.220.514
2r3jSCJCyclin-dependent kinase 22.7.11.220.512
3qzhX69Cyclin-dependent kinase 22.7.11.220.512
3r6xX84Cyclin-dependent kinase 22.7.11.220.512
1ke7LS3Cyclin-dependent kinase 22.7.11.220.511
4fkpLS5Cyclin-dependent kinase 22.7.11.220.511
3qu0X40Cyclin-dependent kinase 22.7.11.220.510
3sqq99ZCyclin-dependent kinase 22.7.11.220.509
1oiqHDUCyclin-dependent kinase 22.7.11.220.508
2btrU73Cyclin-dependent kinase 22.7.11.220.508
3qtxX43Cyclin-dependent kinase 22.7.11.220.508
3r73X87Cyclin-dependent kinase 22.7.11.220.508
4ek816KCyclin-dependent kinase 22.7.11.220.508
1pxjCK2Cyclin-dependent kinase 22.7.11.220.507
1pxmCK5Cyclin-dependent kinase 22.7.11.220.507
2w06FRVCyclin-dependent kinase 22.7.11.220.507
2c6kDT2Cyclin-dependent kinase 22.7.11.220.506
2exmZIPCyclin-dependent kinase 22.7.11.220.506
2w17I19Cyclin-dependent kinase 22.7.11.220.505
4bcpT3CCyclin-dependent kinase 22.7.11.220.505
4kd11QKCyclin-dependent kinase 22.7.11.220.505
1vyzN5BCyclin-dependent kinase 22.7.11.220.504
2c6lDT4Cyclin-dependent kinase 22.7.11.220.504
3iggEFQCyclin-dependent kinase 22.7.11.220.504
3r7uX96Cyclin-dependent kinase 22.7.11.220.504
1ykr628Cyclin-dependent kinase 22.7.11.220.503
3pj8404Cyclin-dependent kinase 22.7.11.220.503
3r9dX6BCyclin-dependent kinase 22.7.11.220.502
3r9hZ67Cyclin-dependent kinase 22.7.11.220.502
1oguST8Cyclin-dependent kinase 22.7.11.220.501
4acm7YGCyclin-dependent kinase 22.7.11.220.501
4fkq42KCyclin-dependent kinase 22.7.11.220.501
1b38ATPCyclin-dependent kinase 22.7.11.220.500
1h1s4SPCyclin-dependent kinase 22.7.11.220.500
3r1sX73Cyclin-dependent kinase 22.7.11.220.500
1di8DTQCyclin-dependent kinase 22.7.11.220.499
3r7iX9ICyclin-dependent kinase 22.7.11.220.498
3rkb12ZCyclin-dependent kinase 22.7.11.220.498
1pxlCK4Cyclin-dependent kinase 22.7.11.220.497
3qtrX36Cyclin-dependent kinase 22.7.11.220.496
1v1k3FPCyclin-dependent kinase 22.7.11.220.495
3rjc06ZCyclin-dependent kinase 22.7.11.220.495
4fkg4CKCyclin-dependent kinase 22.7.11.220.494
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.492
3rpr25ZCyclin-dependent kinase 22.7.11.220.492
1oiuN76Cyclin-dependent kinase 22.7.11.220.491
1oiyN41Cyclin-dependent kinase 22.7.11.220.491
3r8lZ30Cyclin-dependent kinase 22.7.11.220.491
3rni21ZCyclin-dependent kinase 22.7.11.220.491
3qxoX65Cyclin-dependent kinase 22.7.11.220.490
3rk507ZCyclin-dependent kinase 22.7.11.220.490
4bcnT9NCyclin-dependent kinase 22.7.11.220.490
4bgh3I6Cyclin-dependent kinase 22.7.11.220.490
1pxkCK3Cyclin-dependent kinase 22.7.11.220.489
1y91CT9Cyclin-dependent kinase 22.7.11.220.489
3qwkX62Cyclin-dependent kinase 22.7.11.220.489
4eon1ROCyclin-dependent kinase 22.7.11.220.489
1ke8LS4Cyclin-dependent kinase 22.7.11.220.488
3qqfX07Cyclin-dependent kinase 22.7.11.220.488
3ti1B49Cyclin-dependent kinase 22.7.11.220.488
1h1q2A6Cyclin-dependent kinase 22.7.11.220.487
1oi9N20Cyclin-dependent kinase 22.7.11.220.487
2b55D31Cyclin-dependent kinase 22.7.11.220.487
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.487
2vu3LZECyclin-dependent kinase 22.7.11.220.487
2vv9IM9Cyclin-dependent kinase 22.7.11.220.487
3rk909ZCyclin-dependent kinase 22.7.11.220.487
3ezvEZVCyclin-dependent kinase 22.7.11.220.486
1b39ATPCyclin-dependent kinase 22.7.11.220.485
1ke5LS1Cyclin-dependent kinase 22.7.11.220.485
1ke6LS2Cyclin-dependent kinase 22.7.11.220.485
2r3mSCXCyclin-dependent kinase 22.7.11.220.485
1g5sI17Cyclin-dependent kinase 22.7.11.220.484
3r1qX75Cyclin-dependent kinase 22.7.11.220.484
4fkw62KCyclin-dependent kinase 22.7.11.220.484
2iw94SPCyclin-dependent kinase 22.7.11.220.483
3qqkX02Cyclin-dependent kinase 22.7.11.220.483
1ckpPVBCyclin-dependent kinase 22.7.11.220.482
3r9nZ68Cyclin-dependent kinase 22.7.11.220.481
2btsU32Cyclin-dependent kinase 22.7.11.220.480
3ig7EFPCyclin-dependent kinase 22.7.11.220.480
4ez30S0Cyclin-dependent kinase 22.7.11.220.480
4fko20KCyclin-dependent kinase 22.7.11.220.480
3rpv26ZCyclin-dependent kinase 22.7.11.220.478
4eor4SPCyclin-dependent kinase 22.7.11.220.478
4fki09KCyclin-dependent kinase 22.7.11.220.478
1gih1PUCyclin-dependent kinase 22.7.11.220.477
3ddpRC8Cyclin-dependent kinase 22.7.11.220.477
3ral04ZCyclin-dependent kinase 22.7.11.220.477
4lyn1YGCyclin-dependent kinase 22.7.11.220.477
1urwI1PCyclin-dependent kinase 22.7.11.220.476
3s0o50ZCyclin-dependent kinase 22.7.11.220.476
4eok4SPCyclin-dependent kinase 22.7.11.220.476
1gij2PUCyclin-dependent kinase 22.7.11.220.475
1gz8MBPCyclin-dependent kinase 22.7.11.220.475
4erwSTUCyclin-dependent kinase 22.7.11.220.475
1aq1STUCyclin-dependent kinase 22.7.11.220.474
1pyePM1Cyclin-dependent kinase 22.7.11.220.474
1gii1PUCyclin-dependent kinase 22.7.11.220.473
3wblPDYCyclin-dependent kinase 22.7.11.220.473
2uzoC62Cyclin-dependent kinase 22.7.11.220.472
4fv9E71Mitogen-activated protein kinase 12.7.11.240.472
1e1vCMGCyclin-dependent kinase 22.7.11.220.470
1p2a5BNCyclin-dependent kinase 22.7.11.220.470
3qx4X4BCyclin-dependent kinase 22.7.11.220.470
4bcmT7ZCyclin-dependent kinase 22.7.11.220.470
2c5yMTWCyclin-dependent kinase 22.7.11.220.469
2vttLZDCyclin-dependent kinase 22.7.11.220.469
3ezrEZRCyclin-dependent kinase 22.7.11.220.469
3qruX19Cyclin-dependent kinase 22.7.11.220.468
4fkv61KCyclin-dependent kinase 22.7.11.220.468
2c4g514Cyclin-dependent kinase 22.7.11.220.466
2duv371Cyclin-dependent kinase 22.7.11.220.466
2wpa889Cyclin-dependent kinase 22.7.11.220.466
4bcoT6QCyclin-dependent kinase 22.7.11.220.466
4fx360KCyclin-dependent kinase 22.7.11.220.466
1v0pPVBCell division control protein 2 homolog2.7.11.220.465
3qxpX64Cyclin-dependent kinase 22.7.11.220.465
3my5RFZCyclin-dependent kinase 22.7.11.220.464
3sw418KCyclin-dependent kinase 22.7.11.220.462
1y8yCT7Cyclin-dependent kinase 22.7.11.220.461
3fz1B98Cyclin-dependent kinase 22.7.11.220.461
1unlRRCCyclin-dependent-like kinase 52.7.11.10.460
1e9hINRCyclin-dependent kinase 22.7.11.220.459
3ql8X01Cyclin-dependent kinase 22.7.11.220.457
3s00Z60Cyclin-dependent kinase 22.7.11.220.457
3r8pZ46Cyclin-dependent kinase 22.7.11.220.456
1oirHDYCyclin-dependent kinase 22.7.11.220.455
1pxoCK7Cyclin-dependent kinase 22.7.11.220.455
2b7aIZATyrosine-protein kinase JAK2/0.455
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.455
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
3lfsA07Cyclin-dependent kinase 22.7.11.220.454
3pxyJWSCyclin-dependent kinase 22.7.11.220.454
3qtqX35Cyclin-dependent kinase 22.7.11.220.453
2w1hL0FCyclin-dependent kinase 22.7.11.220.452
3r7eX88Cyclin-dependent kinase 22.7.11.220.452
1h1pCMGCyclin-dependent kinase 22.7.11.220.451
1pkdUCNCyclin-dependent kinase 22.7.11.220.451
2x1nX1NCyclin-dependent kinase 22.7.11.220.451
1vyw292Cyclin-dependent kinase 22.7.11.220.450
2wotZZGTGF-beta receptor type-12.7.11.300.450
3qrtX14Cyclin-dependent kinase 22.7.11.220.450
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
3unj0BXCyclin-dependent kinase 22.7.11.220.449
4fks46KCyclin-dependent kinase 22.7.11.220.449
1fvv107Cyclin-dependent kinase 22.7.11.220.448
1hckATPCyclin-dependent kinase 22.7.11.220.448
2b53D23Cyclin-dependent kinase 22.7.11.220.448
3nynSGVG protein-coupled receptor kinase 62.7.11.160.448
4bcqTJFCyclin-dependent kinase 22.7.11.220.448
2xmyCDKCyclin-dependent kinase 22.7.11.220.447
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.447
2c6tDT5Cyclin-dependent kinase 22.7.11.220.446
3qyw6PBMitogen-activated protein kinase 12.7.11.240.446
3unk0BYCyclin-dependent kinase 22.7.11.220.446
2bhhRYUCyclin-dependent kinase 22.7.11.220.445
2j0lANPFocal adhesion kinase 12.7.10.20.445
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.445
2vtqLZACyclin-dependent kinase 22.7.11.220.445
3dogNNNCyclin-dependent kinase 22.7.11.220.445
4cfnJYMCyclin-dependent kinase 22.7.11.220.445
1pxpCK8Cyclin-dependent kinase 22.7.11.220.444
3le62BZCyclin-dependent kinase 22.7.11.220.444
1r78FMDCyclin-dependent kinase 22.7.11.220.443
2uzlC94Cyclin-dependent kinase 22.7.11.220.443
2wxvWXVCyclin-dependent kinase 22.7.11.220.443
2vthLZ2Cyclin-dependent kinase 22.7.11.220.442
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.441
3py0SU9Cyclin-dependent kinase 22.7.11.220.441
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.440
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3uli1N3Cyclin-dependent kinase 22.7.11.220.440
4eos1ROCyclin-dependent kinase 22.7.11.220.440
4fv6E57Mitogen-activated protein kinase 12.7.11.240.440
4fv8E63Mitogen-activated protein kinase 12.7.11.240.440
4ii5ADPCyclin-dependent kinase 22.7.11.220.440