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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r3fSC8Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2r3fSC8Cyclin-dependent kinase 22.7.11.221.000
2r3gSC9Cyclin-dependent kinase 22.7.11.220.682
2r3p3SCCyclin-dependent kinase 22.7.11.220.681
2r3q5SCCyclin-dependent kinase 22.7.11.220.679
2r3iSCFCyclin-dependent kinase 22.7.11.220.673
2c6iDT1Cyclin-dependent kinase 22.7.11.220.634
2r3kSCQCyclin-dependent kinase 22.7.11.220.610
3rahO1ZCyclin-dependent kinase 22.7.11.220.597
2c69CT8Cyclin-dependent kinase 22.7.11.220.587
3r83Z14Cyclin-dependent kinase 22.7.11.220.583
2r3mSCXCyclin-dependent kinase 22.7.11.220.573
2r3r6SCCyclin-dependent kinase 22.7.11.220.573
2r3o2SCCyclin-dependent kinase 22.7.11.220.572
1w8cN69Cyclin-dependent kinase 22.7.11.220.566
3r7yZ04Cyclin-dependent kinase 22.7.11.220.563
3iggEFQCyclin-dependent kinase 22.7.11.220.555
3lfnA27Cyclin-dependent kinase 22.7.11.220.552
3rm719ZCyclin-dependent kinase 22.7.11.220.549
3r8uZ31Cyclin-dependent kinase 22.7.11.220.543
4fklCK2Cyclin-dependent kinase 22.7.11.220.542
2a0cCK9Cyclin-dependent kinase 22.7.11.220.534
3rm618ZCyclin-dependent kinase 22.7.11.220.534
3r9nZ68Cyclin-dependent kinase 22.7.11.220.533
2r3jSCJCyclin-dependent kinase 22.7.11.220.532
2r3lSCWCyclin-dependent kinase 22.7.11.220.532
3qx2X63Cyclin-dependent kinase 22.7.11.220.531
4kd11QKCyclin-dependent kinase 22.7.11.220.528
3lfqA28Cyclin-dependent kinase 22.7.11.220.527
3r7iX9ICyclin-dependent kinase 22.7.11.220.527
3wblPDYCyclin-dependent kinase 22.7.11.220.527
3r7uX96Cyclin-dependent kinase 22.7.11.220.526
3qzhX69Cyclin-dependent kinase 22.7.11.220.524
2uznC96Cyclin-dependent kinase 22.7.11.220.520
3r8vZ62Cyclin-dependent kinase 22.7.11.220.520
2c68CT6Cyclin-dependent kinase 22.7.11.220.519
3ezrEZRCyclin-dependent kinase 22.7.11.220.516
3lfsA07Cyclin-dependent kinase 22.7.11.220.516
3r8lZ30Cyclin-dependent kinase 22.7.11.220.516
2c6mDT5Cyclin-dependent kinase 22.7.11.220.515
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.515
3r7vZ02Cyclin-dependent kinase 22.7.11.220.515
2b54D05Cyclin-dependent kinase 22.7.11.220.514
2a4lRRCCyclin-dependent kinase 22.7.11.220.513
2uzoC62Cyclin-dependent kinase 22.7.11.220.512
3r71X86Cyclin-dependent kinase 22.7.11.220.512
1pxjCK2Cyclin-dependent kinase 22.7.11.220.511
3pj8404Cyclin-dependent kinase 22.7.11.220.511
3rak03ZCyclin-dependent kinase 22.7.11.220.509
3ral04ZCyclin-dependent kinase 22.7.11.220.507
2c6kDT2Cyclin-dependent kinase 22.7.11.220.506
4fkt48KCyclin-dependent kinase 22.7.11.220.506
2vtsLZCCyclin-dependent kinase 22.7.11.220.505
2c6lDT4Cyclin-dependent kinase 22.7.11.220.504
3qqlX03Cyclin-dependent kinase 22.7.11.220.504
3qwjX6ACyclin-dependent kinase 22.7.11.220.504
3qxoX65Cyclin-dependent kinase 22.7.11.220.504
3rni21ZCyclin-dependent kinase 22.7.11.220.504
4ek816KCyclin-dependent kinase 22.7.11.220.504
1oitHDTCyclin-dependent kinase 22.7.11.220.502
1ykr628Cyclin-dependent kinase 22.7.11.220.502
3rpv26ZCyclin-dependent kinase 22.7.11.220.502
4fkg4CKCyclin-dependent kinase 22.7.11.220.502
4fkr45KCyclin-dependent kinase 22.7.11.220.502
3r1yX76Cyclin-dependent kinase 22.7.11.220.499
3qziX72Cyclin-dependent kinase 22.7.11.220.498
3raiX85Cyclin-dependent kinase 22.7.11.220.498
2c6o4SPCyclin-dependent kinase 22.7.11.220.497
2exmZIPCyclin-dependent kinase 22.7.11.220.497
3qtrX36Cyclin-dependent kinase 22.7.11.220.497
3qxpX64Cyclin-dependent kinase 22.7.11.220.497
3rk708ZCyclin-dependent kinase 22.7.11.220.495
3s2pPMUCyclin-dependent kinase 22.7.11.220.495
2w06FRVCyclin-dependent kinase 22.7.11.220.494
3r9dX6BCyclin-dependent kinase 22.7.11.220.494
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.493
3qqhX0ACyclin-dependent kinase 22.7.11.220.493
1w0xOLOCyclin-dependent kinase 22.7.11.220.492
3r9hZ67Cyclin-dependent kinase 22.7.11.220.492
1y8yCT7Cyclin-dependent kinase 22.7.11.220.491
2w05FRTCyclin-dependent kinase 22.7.11.220.491
3ig7EFPCyclin-dependent kinase 22.7.11.220.491
3qruX19Cyclin-dependent kinase 22.7.11.220.491
3s1h56ZCyclin-dependent kinase 22.7.11.220.491
4bgh3I6Cyclin-dependent kinase 22.7.11.220.491
2vttLZDCyclin-dependent kinase 22.7.11.220.490
3r28XA0Cyclin-dependent kinase 22.7.11.220.490
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.489
2c5yMTWCyclin-dependent kinase 22.7.11.220.488
4fkq42KCyclin-dependent kinase 22.7.11.220.488
1oiyN41Cyclin-dependent kinase 22.7.11.220.487
3ddqRRCCyclin-dependent kinase 22.7.11.220.487
1h0vUN4Cyclin-dependent kinase 22.7.11.220.485
1pxlCK4Cyclin-dependent kinase 22.7.11.220.485
1pxmCK5Cyclin-dependent kinase 22.7.11.220.484
2fvdLIACyclin-dependent kinase 22.7.11.220.483
3qtsX46Cyclin-dependent kinase 22.7.11.220.483
3rpo24ZCyclin-dependent kinase 22.7.11.220.481
3qqkX02Cyclin-dependent kinase 22.7.11.220.480
2vu3LZECyclin-dependent kinase 22.7.11.220.479
3ezvEZVCyclin-dependent kinase 22.7.11.220.479
1pxpCK8Cyclin-dependent kinase 22.7.11.220.478
2b55D31Cyclin-dependent kinase 22.7.11.220.477
3r73X87Cyclin-dependent kinase 22.7.11.220.477
1h0w207Cyclin-dependent kinase 22.7.11.220.476
3qzgX67Cyclin-dependent kinase 22.7.11.220.476
4fkpLS5Cyclin-dependent kinase 22.7.11.220.476
1p2a5BNCyclin-dependent kinase 22.7.11.220.475
3qtxX43Cyclin-dependent kinase 22.7.11.220.474
3rjc06ZCyclin-dependent kinase 22.7.11.220.474
3roy22ZCyclin-dependent kinase 22.7.11.220.474
3rpr25ZCyclin-dependent kinase 22.7.11.220.474
4fko20KCyclin-dependent kinase 22.7.11.220.474
2wpa889Cyclin-dependent kinase 22.7.11.220.473
3r1sX73Cyclin-dependent kinase 22.7.11.220.473
3r8pZ46Cyclin-dependent kinase 22.7.11.220.473
3rk909ZCyclin-dependent kinase 22.7.11.220.473
2w17I19Cyclin-dependent kinase 22.7.11.220.472
1ke7LS3Cyclin-dependent kinase 22.7.11.220.471
2r64740Cyclin-dependent kinase 22.7.11.220.471
3sqq99ZCyclin-dependent kinase 22.7.11.220.471
1b38ATPCyclin-dependent kinase 22.7.11.220.470
1oiqHDUCyclin-dependent kinase 22.7.11.220.470
3rkb12ZCyclin-dependent kinase 22.7.11.220.470
4acm7YGCyclin-dependent kinase 22.7.11.220.469
1h1s4SPCyclin-dependent kinase 22.7.11.220.468
2b52D42Cyclin-dependent kinase 22.7.11.220.468
1g5sI17Cyclin-dependent kinase 22.7.11.220.467
2j9mPY8Cyclin-dependent kinase 22.7.11.220.466
3qtzX42Cyclin-dependent kinase 22.7.11.220.466
4fks46KCyclin-dependent kinase 22.7.11.220.466
1e1xNW1Cyclin-dependent kinase 22.7.11.220.465
1gih1PUCyclin-dependent kinase 22.7.11.220.464
1gz8MBPCyclin-dependent kinase 22.7.11.220.464
1unlRRCCyclin-dependent-like kinase 52.7.11.10.463
2btrU73Cyclin-dependent kinase 22.7.11.220.463
4fkv61KCyclin-dependent kinase 22.7.11.220.463
3qwkX62Cyclin-dependent kinase 22.7.11.220.462
1vyw292Cyclin-dependent kinase 22.7.11.220.461
4btjATPTau-tubulin kinase 12.7.11.10.461
1pxoCK7Cyclin-dependent kinase 22.7.11.220.460
2vv9IM9Cyclin-dependent kinase 22.7.11.220.460
3rk507ZCyclin-dependent kinase 22.7.11.220.460
4fkj11KCyclin-dependent kinase 22.7.11.220.460
1ke6LS2Cyclin-dependent kinase 22.7.11.220.459
1urwI1PCyclin-dependent kinase 22.7.11.220.459
3r6xX84Cyclin-dependent kinase 22.7.11.220.459
1fvt106Cyclin-dependent kinase 22.7.11.220.458
3unk0BYCyclin-dependent kinase 22.7.11.220.458
1oirHDYCyclin-dependent kinase 22.7.11.220.457
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.457
1gii1PUCyclin-dependent kinase 22.7.11.220.456
1v1k3FPCyclin-dependent kinase 22.7.11.220.455
3sw719KCyclin-dependent kinase 22.7.11.220.455
4btjADPTau-tubulin kinase 12.7.11.10.455
2bheBRYCyclin-dependent kinase 22.7.11.220.454
3qtwX3ACyclin-dependent kinase 22.7.11.220.454
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.453
4erwSTUCyclin-dependent kinase 22.7.11.220.453
4lyn1YGCyclin-dependent kinase 22.7.11.220.453
2xmyCDKCyclin-dependent kinase 22.7.11.220.452
3pxyJWSCyclin-dependent kinase 22.7.11.220.452
3qu0X40Cyclin-dependent kinase 22.7.11.220.452
4bcoT6QCyclin-dependent kinase 22.7.11.220.452
4eor4SPCyclin-dependent kinase 22.7.11.220.452
4bcpT3CCyclin-dependent kinase 22.7.11.220.451
2b53D23Cyclin-dependent kinase 22.7.11.220.450
3sw418KCyclin-dependent kinase 22.7.11.220.450
3efwAK8Aurora kinase A2.7.11.10.449
1di8DTQCyclin-dependent kinase 22.7.11.220.448
2w1hL0FCyclin-dependent kinase 22.7.11.220.448
3my5RFZCyclin-dependent kinase 22.7.11.220.448
1b39ATPCyclin-dependent kinase 22.7.11.220.446
1oguST8Cyclin-dependent kinase 22.7.11.220.446
3r8zZ63Cyclin-dependent kinase 22.7.11.220.446
4fv8E63Mitogen-activated protein kinase 12.7.11.240.446
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.445
3qtuX44Cyclin-dependent kinase 22.7.11.220.445
3rmf20ZCyclin-dependent kinase 22.7.11.220.445
2uzlC94Cyclin-dependent kinase 22.7.11.220.444
3r1qX75Cyclin-dependent kinase 22.7.11.220.444
4fkw62KCyclin-dependent kinase 22.7.11.220.444
1e9hINRCyclin-dependent kinase 22.7.11.220.443
1ke5LS1Cyclin-dependent kinase 22.7.11.220.443
3ddpRC8Cyclin-dependent kinase 22.7.11.220.443
3qyw6PBMitogen-activated protein kinase 12.7.11.240.443
4eok4SPCyclin-dependent kinase 22.7.11.220.443
3qtqX35Cyclin-dependent kinase 22.7.11.220.442
1oiuN76Cyclin-dependent kinase 22.7.11.220.441
4fx360KCyclin-dependent kinase 22.7.11.220.441