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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2r2gEMFEugenol synthase 11.1.1.318

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2r2gEMFEugenol synthase 11.1.1.3181.000
1h36R88Squalene--hopene cyclase4.2.1.1290.495
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.495
4bj9UHBTankyrase-22.4.2.300.493
1aiqCB3Thymidylate synthase/0.492
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.490
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.490
1jtuLYBThymidylate synthase/0.489
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.486
1o6qR17Squalene--hopene cyclase4.2.1.1290.484
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.482
1o6rR19Squalene--hopene cyclase4.2.1.1290.480
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.478
1p8dCO1Oxysterols receptor LXR-beta/0.476
1h35R01Squalene--hopene cyclase4.2.1.1290.474
3q43D66M1 family aminopeptidase3.4.110.474
3l6jZ90Alr2278 protein/0.473
5g53NECAdenosine receptor A2a/0.473
2fjdSFDAdenylylsulfate reductase, subunit A (AprA)/0.472
2j9lATPH(+)/Cl(-) exchange transporter 5/0.472
3f3y4OABile salt sulfotransferase2.8.2.140.472
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.472
3cr0809Wee1-like protein kinase2.7.10.20.470
1upw444Oxysterols receptor LXR-beta/0.469
4l5b1UXDeoxycytidine kinase2.7.1.740.469
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.467
3q0uLL3HTH-type transcriptional regulator EthR/0.467
4bfvZVVPantothenate kinase2.7.1.330.467
2aclL05Oxysterols receptor LXR-alpha/0.466
4iae1DXAlr2278 protein/0.466
4xba5GPAprataxin-like protein30.466
1u65CP0Acetylcholinesterase3.1.1.70.465
3up0D7SaceDAF-12/0.465
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
2vbpVB1Isopenicillin N synthase1.21.3.10.464
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.464
4i9i1DYTankyrase-12.4.2.300.464
4jqh1MFAlr2278 protein/0.464
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.463
1uydPU8Heat shock protein HSP 90-alpha/0.462
3pqbVGPPutative oxidoreductase/0.462
1pj7FFODimethylglycine oxidase1.5.3.100.461
2ociTYCValacyclovir hydrolase3.10.461
2vxkCOAGlucosamine 6-phosphate acetyltransferase, putative/0.461
2xlrFADPutative flavin-containing monooxygenase/0.461
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.461
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
4n4t2GVTankyrase-12.4.2.300.461
4rv9SAHD-mycarose 3-C-methyltransferase/0.461
2gvcFADThiol-specific monooxygenase1.14.130.460
2pncCLUPrimary amine oxidase, liver isozyme/0.460
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.460
4pnmNU1Tankyrase-22.4.2.300.460
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.459
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.459
2yjxYJXHeat shock protein HSP 90-alpha/0.459
2zscBTNTamavidin2/0.459
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
1pqc444Oxysterols receptor LXR-beta/0.458
3biz61EWee1-like protein kinase2.7.10.20.458
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3tp0FO5HTH-type transcriptional regulator EthR/0.458
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.458
3wypBSOStreptavidin/0.458
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.458
3b82NADExotoxin A2.4.2.360.457
3ou2SAHSAM-dependent methyltransferase/0.457
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.457
3qh23NMThiazole tautomerase/0.457
4zobLGCLin1840 protein/0.457
1tllFADNitric oxide synthase, brain1.14.13.390.456
1wxyFRKAdenosine deaminase3.5.4.40.456
2uywBTNAvd protein/0.456
3dh8B4NUncharacterized protein PA1000/0.456
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.456
3sn6P0GBeta-2 adrenergic receptor/0.456
3ny8JRZBeta-2 adrenergic receptor/0.456
1fcy564Retinoic acid receptor gamma/0.455
1oc1ASVIsopenicillin N synthase1.21.3.10.455
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
1yf3SAHDNA adenine methylase/0.455
2xveFADPutative flavin-containing monooxygenase/0.455
4dk70KSOxysterols receptor LXR-beta/0.455
2hq9FADMll6688 protein/0.454
3e23SAMUncharacterized protein/0.454
3gkiCLRNiemann-Pick C1 protein/0.454
3q9bB3NAcetylpolyamine amidohydrolase/0.454
4tjy3GNTankyrase-22.4.2.300.454
1fcx184Retinoic acid receptor gamma/0.453
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2vceU2FUDP-glycosyltransferase 72B1/0.453
2vqqTFGHistone deacetylase 43.5.1.980.453
3pfhT3QdTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase2.1.1.2350.453
3up3XCAaceDAF-12/0.453
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.453
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.453
4lb2DM5Serum albumin/0.453
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.453
5k2bZMAAdenosine receptor A2a/0.453
4s0vSUVOrexin receptor type 2/0.453
3ny9JSZBeta-2 adrenergic receptor/0.453
1yhjR6CPyridoxal kinase2.7.1.350.452
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.452
4tkg09LTankyrase-22.4.2.300.452
1bk0ACVIsopenicillin N synthase1.21.3.10.451
1ie8KH1Vitamin D3 receptor/0.451
1swnBTNStreptavidin/0.451
1u1d181Uridine phosphorylase2.4.2.30.451
1uyePU9Heat shock protein HSP 90-alpha/0.451
1yqzCOACoenzyme A disulfide reductase/0.451
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.451
2h2aDNDProbable nicotinate-nucleotide adenylyltransferase/0.451
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4dvi2IWTankyrase-12.4.2.300.451
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.451
4twnB96Ephrin type-A receptor 32.7.10.10.451
3biy01KHistone acetyltransferase p300/0.450
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.450
4nh82LCHeat shock protein HSP 90-alpha/0.450
3qakUKAAdenosine receptor A2a/0.450
1drfFOLDihydrofolate reductase1.5.1.30.449
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.449
1s36CEIObelin/0.449
3anpDCCTranscriptional repressor, TetR family/0.449
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.449
3nwlNDPCatalase1.11.1.60.449
4h8004TAldehyde dehydrogenase, dimeric NADP-preferring/0.449
4n3r2GUTankyrase-12.4.2.300.449
5uviZMAAdenosine receptor A2a/0.449
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1v79FR7Adenosine deaminase3.5.4.40.448
2bfmTOPPteridine reductase 11.5.1.330.448
2uz2BTNAvd protein/0.448
3v2uATPProtein GAL3/0.448
3vhiVHIAvidin/0.448
3vt7VDXVitamin D3 receptor/0.448
4fqsLYAThymidylate synthase ThyA/0.448
4ktl1CQCytochrome P450/0.448
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.448
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.447
3a1l2CCCytochrome P450/0.447
3ipq965Oxysterols receptor LXR-alpha/0.447
5jtbZMAAdenosine receptor A2a/0.447
1bq1CB3Thymidylate synthase/0.446
1dghNDPCatalase1.11.1.60.446
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2pl0STITyrosine-protein kinase Lck2.7.10.20.446
2qg2A91Heat shock protein HSP 90-alpha/0.446
2vleDZNAldehyde dehydrogenase, mitochondrial1.2.1.30.446
2wmdZZ0NmrA-like family domain-containing protein 1/0.446
3a8iC2FAminomethyltransferase2.1.2.100.446
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.446
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.446
3v94WYQPhosphodiesterase/0.446
3zkyWT4Isopenicillin N synthase1.21.3.10.446
4iah1DXAlr2278 protein/0.446
4jq3NAPAldo-keto reductase family 1 member C2/0.446
4phlPILPhosphodiesterase/0.446
1uyfPU1Heat shock protein HSP 90-alpha/0.445
1x8lOXRRetinol dehydratase/0.445
2fjbSFDAdenylylsulfate reductase, subunit A (AprA)/0.445
2hx44HXNitric oxide synthase, brain1.14.13.390.445
2r04W71Genome polyprotein/0.445
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.445
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
3jynNDPQuinone oxidoreductase/0.445
4bfwZVWPantothenate kinase2.7.1.330.445
4dm6TTBRetinoic acid receptor beta/0.445
4li61XOTankyrase-12.4.2.300.445
4rvgTYDD-mycarose 3-C-methyltransferase/0.445
2rh1CAUBeta-2 adrenergic receptor/0.445
3pblETQD(3) dopamine receptor/0.445
2bfaCB3Pteridine reductase 11.5.1.330.444
3eufBAUUridine phosphorylase 1/0.444
3ft8MOJHeat shock protein HSP 90-alpha/0.444
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3k9uACOSpermidine N(1)-acetyltransferase/0.444
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.444
4at0FADPossible succinate dehydrogenase/0.444
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.444
4g95OAGDihydrofolate reductase1.5.1.30.444
4hyf1AKTankyrase-22.4.2.300.444
1fvpFMANon-fluorescent flavoprotein/0.443
1galFADGlucose oxidase1.1.3.40.443
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.443
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.443
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1zg32HIIsoflavone 4'-O-methyltransferase/0.443
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2y60M8FIsopenicillin N synthase1.21.3.10.443
3da24MDCarbonic anhydrase 134.2.1.10.443
3lkhLT6Genome polyprotein2.7.7.480.443
3v0o4GWHisto-blood group ABO system transferase/0.443
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.443
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.443
4dhyS41Glucokinase2.7.1.20.443
4dpf0LGBeta-secretase 13.4.23.460.443
4iarERM5-hydroxytryptamine receptor 1B/0.443
4j6dTESCytochrome P450 monooxygenase/0.443
5ab6CAANonspecific lipid-transfer protein, putative/0.443
1cdoNADAlcohol dehydrogenase 11.1.1.10.442
1j4jACOAcetyltransferase2.3.10.442
1nbiSAMGlycine N-methyltransferase2.1.1.200.442
1pq944BOxysterols receptor LXR-beta/0.442
1qjfACSIsopenicillin N synthase1.21.3.10.442
1qorNDPQuinone oxidoreductase 1/0.442
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.442
1xf0ASDAldo-keto reductase family 1 member C3/0.442
2harOCCVitamin D3 receptor/0.442
2hbhXE4Vitamin D3 receptor A/0.442
2re8GSUGlutamine--tRNA ligase6.1.1.180.442
2zwaSAHtRNA wybutosine-synthesizing protein 42.1.1.2900.442
3bgiSAHThiopurine S-methyltransferase2.1.1.670.442
3cqeP91Wee1-like protein kinase2.7.10.20.442
3ou6SAMSAM-dependent methyltransferase/0.442
4a0sCO8Octenoyl-CoA reductase/carboxylase/0.442
4jlj1NMDeoxycytidine kinase2.7.1.740.442
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
1n4uFAECholesterol oxidase1.1.3.60.441
1synF89Thymidylate synthase/0.441
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.441
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.441
3arvSAUChitinase A/0.441
3b9oFMNAlkane monoxygenase/0.441
3g1lRF2HTH-type transcriptional regulator EthR/0.441
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3u8hBHPPhospholipase A2, membrane associated/0.441
3vg9ZMAAdenosine receptor A2a/0.441
3zoiM2WIsopenicillin N synthase1.21.3.10.441
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.441
4kxjP34Nucleoprotein/0.441
4rtsSAMDNA adenine methylase2.1.1.720.441
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.441
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.440
1pq6965Oxysterols receptor LXR-beta/0.440
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.440
2fhlBNIAvidin-related protein 4/5/0.440
2hzqSTRApolipoprotein D/0.440
2idkC2FGlycine N-methyltransferase2.1.1.200.440
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.440
3w0uHPWLactoylglutathione lyase4.4.1.50.440
4g3jVNTLanosterol 14-alpha-demethylase/0.440
4jtrIZPAldo-keto reductase family 1 member C2/0.440
5jqhCAUBeta-2 adrenergic receptor/0.440