sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2qxw | LDT | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.814 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.807 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.777 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.752 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.751 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.739 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.729 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.722 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.712 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.711 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.705 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.703 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.689 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.687 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.680 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.667 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.663 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.654 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.650 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.650 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.647 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.639 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.636 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.636 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.636 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.624 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.621 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.619 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.618 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.606 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.606 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.606 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.606 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.605 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.604 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.604 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.603 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.602 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.597 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.596 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.596 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.590 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.590 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.590 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.588 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.587 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.585 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.585 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.584 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.574 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.573 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.565 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.543 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.543 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.531 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.526 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.506 | |
| 2pdy | FID | Aldose reductase | 1.1.1.21 | 0.502 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.502 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.496 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.495 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.494 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.490 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.490 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.489 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.488 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.487 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.486 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.484 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.484 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.484 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.483 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.483 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.483 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.482 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.482 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.481 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.479 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.479 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.479 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.478 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.477 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.477 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.477 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.476 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.475 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.474 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.474 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.474 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.472 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.472 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.470 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.470 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.469 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.468 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.468 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.467 | |
| 1ndy | FR3 | Adenosine deaminase | 3.5.4.4 | 0.467 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.467 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.467 | |
| 3ny8 | JRZ | Beta-2 adrenergic receptor | / | 0.467 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.466 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 1lke | DOG | Bilin-binding protein | / | 0.463 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.463 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 1rxj | BNI | Streptavidin | / | 0.461 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.461 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.461 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.460 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.460 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.460 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4phl | PIL | Phosphodiesterase | / | 0.460 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.459 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.458 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.458 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.458 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.458 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.457 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.457 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.457 | |
| 2v5u | FMN | Flavodoxin | / | 0.457 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.457 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.457 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.456 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4xwt | U5P | Ribonuclease J | / | 0.456 | |
| 1c7o | PPG | Hemolysin | / | 0.455 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.455 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.455 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.455 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.454 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.454 | |
| 2hzq | STR | Apolipoprotein D | / | 0.453 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.453 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.452 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.452 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.452 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.451 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.451 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.451 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.450 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.450 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.449 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.449 | |
| 4kmz | FOL | Folate receptor beta | / | 0.449 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.449 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.448 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.448 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.448 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.447 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.446 | |
| 1syn | F89 | Thymidylate synthase | / | 0.446 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.446 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.446 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 2hct | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.446 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.445 | |
| 1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.445 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.445 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.444 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.444 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.444 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.444 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.444 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.443 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.443 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.443 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.443 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.443 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.443 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.443 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 4l4v | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.443 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.443 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.442 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.442 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.442 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.442 | |
| 3nya | JTZ | Beta-2 adrenergic receptor | / | 0.442 | |
| 1u1j | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 | 2.1.1.14 | 0.441 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3br2 | DEQ | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3ojg | HL4 | Phosphotriesterase | / | 0.441 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4lrh | FOL | Folate receptor alpha | / | 0.441 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.440 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.440 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.440 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3ocw | 3AM | Lipoprotein E | / | 0.440 | |
| 3upr | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.440 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.440 |