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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2qocANPEphrin type-A receptor 32.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2qocANPEphrin type-A receptor 32.7.10.11.000
4gk4L90Ephrin type-A receptor 32.7.10.10.601
2qo7ANPEphrin type-A receptor 32.7.10.10.577
2qo9ANPEphrin type-A receptor 32.7.10.10.563
4g2fC07Ephrin type-A receptor 32.7.10.10.560
2henADPEphrin type-B receptor 22.7.10.10.541
2qoqANPEphrin type-A receptor 32.7.10.10.536
4gk2L66Ephrin type-A receptor 32.7.10.10.512
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.509
4gk3L87Ephrin type-A receptor 32.7.10.10.509
2y6o1N1Ephrin type-A receptor 42.7.10.10.496
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.493
2xvdAS6Ephrin type-B receptor 42.7.10.10.492
2c6eHPMAurora kinase A2.7.11.10.488
1jpaANPEphrin type-B receptor 22.7.10.10.487
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.486
4jia1K3Tyrosine-protein kinase JAK2/0.485
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.484
1bygSTUTyrosine-protein kinase CSK/0.484
2xyuQ9GEphrin type-A receptor 42.7.10.10.483
1mqbANPEphrin type-A receptor 22.7.10.10.477
3oom507Activin receptor type-12.7.11.300.477
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.475
4j95ACPFibroblast growth factor receptor 2/0.474
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.472
4c3pACPAurora kinase A2.7.11.10.470
2vwu7X1Ephrin type-B receptor 42.7.10.10.468
2of4979Tyrosine-protein kinase Lck2.7.10.20.467
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.464
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
4dymIYZActivin receptor type-12.7.11.300.464
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.463
3vjoANPEpidermal growth factor receptor2.7.10.10.463
4qnyANPMitogen activated protein kinase, putative/0.463
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.462
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2x9fX9FEphrin type-B receptor 42.7.10.10.461
3ac1KZITyrosine-protein kinase Lck2.7.10.20.460
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.460
5cnnANPEpidermal growth factor receptor2.7.10.10.460
2xrwANPMitogen-activated protein kinase 82.7.11.240.459
3i60E86Mitogen-activated protein kinase 12.7.11.240.459
3uvqFS8Mitogen-activated protein kinase 14/0.459
4bb432WEphrin type-B receptor 42.7.10.10.459
4jboWPHAurora kinase A2.7.11.10.459
2itnANPEpidermal growth factor receptor2.7.10.10.458
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.458
2vx07X7Ephrin type-B receptor 42.7.10.10.457
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.457
1i44ACPInsulin receptor2.7.10.10.456
2dcnADP2-keto-3-deoxy-gluconate kinase/0.456
3zewSTUEphrin type-B receptor 42.7.10.10.456
4k33ACPFibroblast growth factor receptor 32.7.10.10.456
3bu5ATPInsulin receptor2.7.10.10.455
4id71G0Activated CDC42 kinase 1/0.455
2itvANPEpidermal growth factor receptor2.7.10.10.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
4jbpYPHAurora kinase A2.7.11.10.454
4xhgADPUncharacterized protein/0.454
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.453
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.453
4qmlANPSerine/threonine-protein kinase 242.7.11.10.453
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.452
1qmzATPCyclin-dependent kinase 22.7.11.220.451
4bgg844Activin receptor type-12.7.11.300.451
2of2547Tyrosine-protein kinase Lck2.7.10.20.450
3kvxFMYMitogen-activated protein kinase 102.7.11.240.450
3oriAGSSerine/threonine protein kinase/0.450
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.450
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
2py3ACPFibroblast growth factor receptor 2/0.449
3mtfA3FActivin receptor type-12.7.11.300.449
5e92ANPTGF-beta receptor type-22.7.11.300.449
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.448
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.448
3ttiKBIMitogen-activated protein kinase 102.7.11.240.447
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.447
4riyADPEpidermal growth factor receptor2.7.10.10.447
3hx4ANPCalmodulin-domain protein kinase 1/0.446
3vs3VSETyrosine-protein kinase HCK2.7.10.20.446
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.446
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.445
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.445
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.445
5dnrATPAurora kinase A2.7.11.10.445
2j0lANPFocal adhesion kinase 12.7.10.20.444
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.444
3c4wATPRhodopsin kinase/0.444
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.444
2v7a627Tyrosine-protein kinase ABL12.7.10.20.443
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.443
3vthAPCCarbamoyltransferase/0.443
2eb3ANPEpidermal growth factor receptor2.7.10.10.442
2ituITQEpidermal growth factor receptor2.7.10.10.442
2o0uC0MMitogen-activated protein kinase 102.7.11.240.442
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.442
2itqITQEpidermal growth factor receptor2.7.10.10.441
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.441
3uozNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.441
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.441
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.441
2excJNKMitogen-activated protein kinase 102.7.11.240.440
2hk51BMTyrosine-protein kinase HCK2.7.10.20.440
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3vs1VSATyrosine-protein kinase HCK2.7.10.20.440
4ux9ANPMitogen-activated protein kinase 82.7.11.240.440
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.440