sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2qk8 | MTX | Dihydrofolate reductase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2qk8 | MTX | Dihydrofolate reductase | / | 1.000 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.647 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.624 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.621 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.619 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.605 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.590 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.588 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.586 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.584 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.582 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.578 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.575 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.575 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.571 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.568 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.560 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.559 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.558 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.558 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.541 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.514 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.501 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.495 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.491 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.489 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.487 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.481 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.479 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.477 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.476 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.476 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.475 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.474 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.474 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.471 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.471 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.470 | |
| 4fv4 | EK7 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.470 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.469 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.469 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1zhz | ERG | Oxysterol-binding protein homolog 4 | / | 0.466 | |
| 4b12 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.466 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.466 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.465 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.464 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.464 | |
| 1c6y | MK1 | Protease | / | 0.463 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 2ji6 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.463 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.463 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.462 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.462 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.462 | |
| 3qaa | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3qly | 55V | Uncharacterized protein | / | 0.462 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.461 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.461 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3eek | 53S | Uncharacterized protein | / | 0.460 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.460 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.460 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.459 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.459 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.459 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.459 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.459 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.458 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.458 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.458 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.458 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.458 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.458 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.457 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1ep3 | FAD | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit | / | 0.457 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.457 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.456 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.456 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.456 | |
| 4e2b | FMN | Dehydrogenase | / | 0.456 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1ozh | HE3 | Acetolactate synthase, catabolic | 2.2.1.6 | 0.455 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.455 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 3p9t | TCL | Repressor | / | 0.455 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.455 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.455 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.454 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.454 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3kfs | 3TL | Gag-Pol polyprotein | / | 0.454 | |
| 3ogq | AB1 | Pol polyprotein | / | 0.454 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.454 | |
| 4c4j | X21 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.454 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.454 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.453 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 4b1f | KRH | Glutamate racemase | / | 0.453 | |
| 4cx3 | HW8 | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.452 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.452 | |
| 3nxe | 2NC | Protease | / | 0.452 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.452 | |
| 5ce3 | ADP | Protein kinase YopO | / | 0.452 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.451 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.451 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.451 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.451 | |
| 1c70 | L75 | Protease | / | 0.450 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.450 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.450 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3ucb | 017 | Gag-Pol polyprotein | / | 0.450 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 4lux | QJ8 | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.449 | |
| 1q6p | 213 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.449 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.449 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.449 | |
| 3em6 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.449 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.449 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.449 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.449 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.449 | |
| 4y12 | AGS | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.449 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.448 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.448 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.448 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.448 | |
| 2uxz | HI1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.448 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.448 | |
| 4l9k | EHF | Serum albumin | / | 0.448 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.447 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.447 | |
| 1mru | AGS | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.447 | |
| 1zdw | FLV | Prenyltransferase | / | 0.447 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.447 | |
| 3vf7 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.447 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 4fv8 | E63 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.447 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1bdr | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.446 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.446 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.446 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.446 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.446 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1tll | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.446 | |
| 2q28 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.446 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.446 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3g6z | A7T | Renin | 3.4.23.15 | 0.446 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.446 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.446 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4o4f | ATP | Kinase | / | 0.446 | |
| 5dos | ATP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1hos | PHP | Gag-Pol polyprotein | / | 0.445 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 1w5x | BE5 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.445 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.445 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2qd7 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.445 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4c4f | 7CE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.445 | |
| 4iae | 1DX | Alr2278 protein | / | 0.445 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.445 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.444 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3d1y | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.444 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.444 | |
| 4c68 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.444 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1ffi | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.443 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.443 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 2p3c | 3TL | Protease | / | 0.443 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.443 | |
| 3bac | 3B9 | DNA ligase | / | 0.443 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.443 | |
| 3ggu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.443 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.443 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.443 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.443 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.442 | |
| 2bqv | A1A | Protease | / | 0.442 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 2pyn | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2q64 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3gcp | SB2 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3rdq | DTB | Streptavidin | / | 0.442 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.442 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.442 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4kba | 1QM | Casein kinase I isoform delta | 2.7.11.1 | 0.442 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.442 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4ucn | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 1aj8 | COA | Citrate synthase | / | 0.441 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.441 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.441 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2nnp | ROC | Protease | / | 0.441 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.441 | |
| 3fzs | B96 | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.441 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3stx | BKA | Methylketone synthase I | / | 0.441 | |
| 3u9e | COA | Lmo1369 protein | / | 0.441 | |
| 3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.441 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.441 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.441 | |
| 4imt | 1EW | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 5cno | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 5dp2 | NAP | CurF | / | 0.441 | |
| 1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.440 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.440 | |
| 1xjj | DGT | Vitamin B12-dependent ribonucleotide reductase | / | 0.440 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2nnk | ROC | Protease | / | 0.440 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2qi3 | MZ5 | Gag-Pol polyprotein | / | 0.440 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2wpx | ACO | Orf14 | / | 0.440 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.440 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3eku | CY9 | Actin-5C | / | 0.440 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.440 | |
| 3lb8 | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.440 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3orm | AGS | Serine/threonine protein kinase | / | 0.440 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3qts | X46 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3rv3 | ADP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 4c2z | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.440 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.440 | |
| 4njs | G08 | Protease | / | 0.440 | |
| 4ye3 | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.440 | |
| 5a3b | APR | SIR2 family protein | / | 0.440 |