sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.677 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.663 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.659 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.650 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.638 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.638 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.623 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.619 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.617 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.611 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.606 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.602 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.602 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.592 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.591 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.588 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.588 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.579 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.575 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.567 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.566 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.554 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.543 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.525 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.521 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.508 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.499 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.497 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.489 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.489 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.483 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.481 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.481 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.480 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.475 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.475 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.475 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.474 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.473 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.473 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.472 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.471 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.471 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.471 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.470 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.468 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.468 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.467 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.466 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.466 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.465 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.465 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.464 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.464 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.464 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.464 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.463 | |
| 3eej | 53R | Uncharacterized protein | / | 0.462 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.460 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.460 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.459 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.459 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.459 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.458 | |
| 3zuy | TCH | Transporter | / | 0.458 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.458 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.458 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.457 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.457 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.457 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.455 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.455 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.454 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.453 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.453 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.453 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.452 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.452 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.452 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.452 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.452 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.452 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.451 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.450 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.450 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.450 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.449 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.449 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.449 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.447 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.447 | |
| 2y3s | TIR | TamL | / | 0.447 | |
| 5a3c | NAD | SIR2 family protein | / | 0.447 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.446 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.446 | |
| 3u9e | COA | Lmo1369 protein | / | 0.446 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.446 | |
| 5a3b | APR | SIR2 family protein | / | 0.446 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.445 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.445 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.444 | |
| 1fml | RTL | Retinol dehydratase | / | 0.444 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.444 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.444 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.444 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.444 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.444 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2bel | CBO | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3gob | HXX | DdmC | / | 0.443 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.443 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.443 | |
| 3wbb | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.443 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.443 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.443 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
| 2y3r | TRK | TamL | / | 0.442 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.442 | |
| 3lu8 | IQX | Serum albumin | / | 0.442 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.441 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.441 | |
| 4h6p | FMN | Chromate reductase | / | 0.441 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.441 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.441 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.441 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3qly | 55V | Uncharacterized protein | / | 0.440 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.440 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.440 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 |