sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2q6c | HR1 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2q6c | HR1 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 1.000 | |
| 2r4f | RIE | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.621 | |
| 2q1l | 882 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.557 | |
| 2q6b | HR2 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.557 | |
| 3cd5 | 7HI | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.554 | |
| 1dq9 | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.523 | |
| 2ghm | LIC | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 1t02 | LVA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.462 | |
| 4i4e | 1BQ | Focal adhesion kinase 1 | 2.7.10.2 | 0.455 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.454 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.454 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1dq8 | COA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.452 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.452 | |
| 4gyi | ADP | Uncharacterized protein | / | 0.451 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.448 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.447 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.444 | |
| 2j7t | 274 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.443 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.443 | |
| 2xcl | ANP | Phosphoribosylamine--glycine ligase | / | 0.443 | |
| 3nnu | EDB | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.443 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 3tdv | GDP | Gentamicin resistance protein | / | 0.442 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.441 | |
| 3lmg | ANP | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.441 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 |