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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2q2qNADBeta-D-hydroxybutyrate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/1.000
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.607
3w8dNAD3-hydroxybutyrate dehydrogenase/0.604
3w8eNAD3-hydroxybutyrate dehydrogenase/0.588
3vdqNAD3-hydroxybutyrate dehydrogenase/0.586
3w8fNAD3-hydroxybutyrate dehydrogenase/0.577
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.575
3qrwNDPPutative ketoacyl reductase1.3.10.572
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.558
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.548
1pr9NAPL-xylulose reductase1.1.1.100.545
1w4zNAPPutative ketoacyl reductase1.3.10.545
1wntNAPL-xylulose reductase1.1.1.100.544
1x7gNAPPutative ketoacyl reductase1.3.10.539
2dteNAIGlucose 1-dehydrogenase related protein/0.538
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.532
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.521
1x7hNDPPutative ketoacyl reductase1.3.10.520
3gy0NAPNAD(P)-dependent oxidoreductase/0.520
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.520
4yaiNAIC alpha-dehydrogenase/0.520
5jlaNADPutative short-chain dehydrogenase/reductase/0.520
4j7xNAPSepiapterin reductase1.1.1.1530.519
1g6kNADGlucose 1-dehydrogenase1.1.1.470.518
1n5dNDPCarbonyl reductase [NADPH] 1/0.518
4dc1NDPPutative ketoacyl reductase1.3.10.518
3toxNAPPutative oxidoreductase/0.516
1ipeNDPTropinone reductase 21.1.1.2360.515
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.515
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.513
2wdzNADGalactitol dehydrogenase/0.513
4hwkNAPSepiapterin reductase1.1.1.1530.510
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.510
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.508
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.508
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.508
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.503
3f1kNAPUncharacterized oxidoreductase YciK10.503
5idwNAPShort-chain dehydrogenase/reductase SDR/0.503
3ai2NDPNADPH-sorbose reductase/0.502
1ae1NAPTropinone reductase 1/0.501
2yutNAPPutative short-chain oxidoreductase/0.501
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.501
1xg5NAPDehydrogenase/reductase SDR family member 11/0.500
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.500
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.500
3lqfNADGalactitol dehydrogenase/0.499
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.499
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.499
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.498
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.498
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.498
4j7uNAPSepiapterin reductase1.1.1.1530.498
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.498
3ak4NADNADH-dependent quinuclidinone reductase/0.495
1gcoNADGlucose 1-dehydrogenase1.1.1.470.494
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.494
4gh5NADShort-chain dehydrogenase/reductase SDR/0.494
4yagNAIC alpha-dehydrogenase/0.494
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.493
4qecNAPElxO/0.492
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.492
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.491
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.491
1geeNADGlucose 1-dehydrogenase1.1.1.470.490
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.490
4esoNAPPutative oxidoreductase/0.490
3p19NDPPutative blue fluorescent protein/0.489
1oaaNAPSepiapterin reductase1.1.1.1530.487
3d3wNAPL-xylulose reductase1.1.1.100.487
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.486
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.484
1rwbNADGlucose 1-dehydrogenase1.1.1.470.483
1snyNAPLD36273p/0.483
2bd0NAPSepiapterin reductase/0.483
2wsbNADGalactitol dehydrogenase/0.483
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.482
5lc1NADL-threonine 3-dehydrogenase/0.482
3sjuNDPKeto reductase/0.481
4b79NADProbable short-chain dehydrogenase/0.481
3wdsNADNADH-dependent quinuclidinone reductase/0.480
1sbyNADAlcohol dehydrogenase1.1.1.10.479
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.479
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.479
4bmvNAPShort-chain dehydrogenase/0.479
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.479
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.478
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.476
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.476
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.474
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.474
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.472
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.470
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.470
3rj5NADAlcohol dehydrogenase1.1.1.10.470
1xkqNDPUncharacterized protein/0.469
1b15NAEAlcohol dehydrogenase1.1.1.10.468
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.468
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.465
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.464
3uxyNADShort-chain dehydrogenase/reductase SDR/0.464
3sx2NADUncharacterized protein/0.463
1zemNADXylitol dehydrogenase/0.461
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.461
1b16NAQAlcohol dehydrogenase1.1.1.10.460
1iy8NADLevodione reductase/0.460
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.460
2p5uNADUDP-glucose 4-epimerase/0.460
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.460
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.459
4impNDPPolyketide synthase extender modules 3-4/0.459
2c0cNAPProstaglandin reductase 310.458
3rj9NADAlcohol dehydrogenase1.1.1.10.458
3s55NADPutative short-chain dehydrogenase/reductase/0.458
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.457
4nbwNADShort-chain dehydrogenase/reductase SDR/0.457
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.455
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.455
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
2yy7NADL-threonine dehydrogenase/0.454
3tn7NJPShort-chain alcohol dehydrogenase/0.454
1mg5NAIAlcohol dehydrogenase1.1.1.10.453
1vrwNAIEnoyl-ACP reductase/0.453
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2nq8ZIDEnoyl-ACP reductase/0.452
2jahNDPClavaldehyde dehydrogenase/0.451
3l77NJPShort-chain alcohol dehydrogenase/0.451
3ai3NDPNADPH-sorbose reductase/0.450
5jy1NADPutative short-chain dehydrogenase/reductase/0.450
4b8wNAPGDP-L-fucose synthase1.1.1.2710.449
5ig2NADShort-chain dehydrogenase/reductase SDR/0.449
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
1v35NAIEnoyl-ACP reductase/0.448
3jynNDPQuinone oxidoreductase/0.446
3bmoNAPPteridine reductase/0.445
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
3uceNDPDehydrogenase/0.444
4fn4NADShort chain dehydrogenase/0.444
1rkxNADCDP-D-glucose-4,6-dehydratase/0.443
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.440
4o1mNADEnoyl-acyl carrier reductase/0.440